2,902 research outputs found
Hyperextended Scalar-Tensor Gravity
We study a general Scalar-Tensor Theory with an arbitrary coupling funtion
but also an arbitrary dependence of the ``gravitational
constant'' in the cases in which either one of them, or both, do not
admit an analytical inverse, as in the hyperextended inflationary scenario. We
present the full set of field equations and study their cosmological behavior.
We show that different scalar-tensor theories can be grouped in classes with
the same solution for the scalar field.Comment: latex file, To appear in Physical Review
Protein aggregate formation permits millennium-old brain preservation
Human proteins have not been reported to survive in free nature, at ambient temperature, for long periods. Particularly, the human brain rapidly dissolves after death due to auto-proteolysis and putrefaction. The here presented discovery of 2600-year-old brain proteins from a radiocarbon dated human brain provides new evidence for extraordinary long-term stability of non-amyloid protein aggregates. Immunoelectron microscopy confirmed the preservation of neurocytoarchitecture in the ancient brain, which appeared shrunken and compact compared to a modern brain. Resolution of intermediate filaments (IFs) from protein aggregates took 2–12 months. Immunoassays on micro-dissected brain tissue homogenates revealed the preservation of the known protein topography for grey and white matter for type III (glial fibrillary acidic protein, GFAP) and IV (neurofilaments, Nfs) IFs. Mass spectrometry data could be matched to a number of peptide sequences, notably for GFAP and Nfs. Preserved immunogenicity of the prehistoric human brain proteins was demonstrated by antibody generation (GFAP, Nfs, myelin basic protein). Unlike brain proteins, DNA was of poor quality preventing reliable sequencing. These long-term data from a unique ancient human brain demonstrate that aggregate formation permits for the preservation of brain proteins for millennia
Simulations of slip flow on nanobubble-laden surfaces
On microstructured hydrophobic surfaces, geometrical patterns may lead to the
appearance of a superhydrophobic state, where gas bubbles at the surface can
have a strong impact on the fluid flow along such surfaces. In particular, they
can strongly influence a detected slip at the surface. We present two-phase
lattice Boltzmann simulations of a flow over structured surfaces with attached
gas bubbles and demonstrate how the detected slip depends on the pattern
geometry, the bulk pressure, or the shear rate. Since a large slip leads to
reduced friction, our results allow to assist in the optimization of
microchannel flows for large throughput.Comment: 22 pages, 12 figure
ALIGNMENT OF HG-AR VAN-DER-WAALS MOLECULE PHOTOFRAGMENTS FOLLOWING PHOTODISSOCIATION
Published versio
Multidimensional Cosmology: Spatially Homogeneous models of dimension 4+1
In this paper we classify all 4+1 cosmological models where the spatial
hypersurfaces are connected and simply connected homogeneous Riemannian
manifolds. These models come in two categories, multiply transitive and simply
transitive models. There are in all five different multiply transitive models
which cannot be considered as a special case of a simply transitive model. The
classification of simply transitive models, relies heavily upon the
classification of the four dimensional (real) Lie algebras. For the orthogonal
case, we derive all the equations of motion and give some examples of exact
solutions. Also the problem of how these models can be compactified in context
with the Kaluza-Klein mechanism, is addressed.Comment: 24 pages, no figures; Refs added, typos corrected. To appear in CQ
Aumento das infestações pela mosca-dos-chifres em bovinos nelore no Pantanal Sul-Mato-Grossense.
Após sua introdução no norte do país na década de 70, a mosca-dos-chifres (Haematobia irritans) chegou à região Centro-Oeste no início dos anos 90. No Pantanal, sua presença foi registrada pela primeira vez em 1991 (Barros, 1992), demandando conhecimento sobre sua ecologia e controle.bitstream/CPAP-2009-09/56780/1/CT80.pdfFormato eletrônico
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.
<i>In vitro</i> Characterization of Phenylacetate Decarboxylase, a Novel Enzyme Catalyzing Toluene Biosynthesis in an Anaerobic Microbial Community
Anaerobic bacterial biosynthesis of toluene from phenylacetate was reported more than two decades ago, but the biochemistry underlying this novel metabolism has never been elucidated. Here we report results of in vitro characterization studies of a novel phenylacetate decarboxylase from an anaerobic, sewage-derived enrichment culture that quantitatively produces toluene from phenylacetate; complementary metagenomic and metaproteomic analyses are also presented. Among the noteworthy findings is that this enzyme is not the well-characterized clostridial p-hydroxyphenylacetate decarboxylase (CsdBC). However, the toluene synthase under study appears to be able to catalyze both phenylacetate and p-hydroxyphenylacetate decarboxylation. Observations suggesting that phenylacetate and p-hydroxyphenylacetate decarboxylation in complex cell-free extracts were catalyzed by the same enzyme include the following: (i) the specific activity for both substrates was comparable in cell-free extracts, (ii) the two activities displayed identical behavior during chromatographic separation of cell-free extracts, (iii) both activities were irreversibly inactivated upon exposure to O2, and (iv) both activities were similarly inhibited by an amide analog of p-hydroxyphenylacetate. Based upon these and other data, we hypothesize that the toluene synthase reaction involves a glycyl radical decarboxylase. This first-time study of the phenylacetate decarboxylase reaction constitutes an important step in understanding and ultimately harnessing it for making bio-based toluene
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