Ring-Closure Mechanisms Mediated by Laccase to Synthesize Phenothiazines, Phenoxazines, and Phenazines

The green and environmentally friendly synthesis of highly valuable organic substances is one possibility for the utilization of laccases (EC 1.10.3.2). As reactants for the herein described syntheses, different o-substituted arylamines or arylthiols and 2,5-dihydroxybenzoic acid and its derivatives were used. In this way, the formation of phenothiazines, phenoxazines, and phenazines was achieved in aqueous solution mediated by the laccase of Pycnoporus cinnabarinus in the presence of oxygen. Two types of phenothiazines (3-hydroxy- and 3-oxo-phenothiazines) formed in one reaction assay were described for the first time. The cyclization reactions yielded C–N, C–S, or C–O bonds. The syntheses were investigated with regard to the substitution pattern of the reaction partners. Differences in C–S and C–N bond formations without cyclization are discussed

Bericht zum Forschungsmonitor "Variable Vergütungssysteme"

Dieser Forschungsbericht zeigt, wie sich die Nutzung variabler Vergütung in Betrieben in Deutschland verändert hat und wie variable Vergütung die Arbeitsqualität beeinflusst. Die Ergebnisse bilden die Entwicklung variabler Vergütung in Deutschland ab

Microbial Community Dynamics during a Harmful Chrysochromulina leadbeateri Bloom in Northern Norway

A harmful algal bloom occurred in late spring 2019 across multiple, interconnected fjords and bays in northern Norway. The event was caused by the haptophyte Chrysochromulina leadbeateri and led to severe fish mortality at several salmon aquaculture facilities. This study reports on the spatial and temporal succession dynamics of the holistic marine microbiome associated with this bloom by relating all detectable 18S and 16S rRNA gene amplicon sequence variants to the relative abundance of the C. leadbeateri focal taxon. A k-medoid clustering enabled inferences on how the causative focal taxon cobloomed with diverse groups of bacteria and microeukaryotes. These coblooming patterns showed high temporal variability and were distinct between two geographically separated time series stations during the regional harmful algal bloom. The distinct blooming patterns observed with respect to each station were poorly connected to environmental conditions, suggesting that other factors, such as biological interactions, may be at least as important in shaping the dynamics of this type of harmful algal bloom. A deeper understanding of microbiome succession patterns during these rare but destructive events will help guide future efforts to forecast deviations from the natural bloom cycles of the northern Norwegian coastal marine ecosystems that are home to intensive aquaculture activities

Arbeitsqualität und wirtschaftlicher Erfolg: Längsschnittstudie in deutschen Betrieben ; Endbericht

Die Studie Arbeitsqualität und wirtschaftlicher Erfolg hat zum Ziel, die Wirkung von Personalmaßnahmen und insbesondere die Zusammenhänge zwischen der Arbeitsqualität der Beschäftigten und dem wirtschaftlichen Erfolg von Betrieben zu untersuchen. Es handelt sich um eine Längsschnittstudie, in der in drei Befragungswellen seit 2012 jeweils eine Betriebs- und eine Beschäftigtenbefragung durchgeführt wurde. Der Abschlussbericht fasst die Daten aus allen Befragungswellen zusammen. Die Forschungsstudie wird vom Bundesministerium für Arbeit und Soziales (BMAS) und vom Institut für Arbeitsmarkt- und Berufsforschung (IAB) getragen und vom IAB, vom Seminar für Allgemeine Betriebswirtschaftslehre und Personalwirtschaftslehre der Universität zu Köln, dem Lehrstuhl für Managerial Accounting der Eberhard Karls Universität Tübingen und vom Zentrum für Europäische Wirtschaftsforschung (ZEW) durchgeführt. In Verlängerung des Forschungsprojekts wir derzeit eine vierte Befragungswelle vorbereitet

RoboFrame - Softwareframework für mobile autonome Robotersysteme

Das Fachgebiet Simulation und Systemoptimierung der Technischen Universität Darmstadt beschäftigt sich mit der Forschung an mobilen autonomen Robotersystemen. Neben der Hardware und robusten Algorithmen zur Robotersteuerung kommt auch der zugrunde liegenden Softwarearchitektur eine zunehmend wichtige Bedeutung zu. In dieser Arbeit wurde ein plattformunabhängiges Framework entwickelt, mit dessen Hilfe eine Robotersteuerung und eine graphische Oberfläche zu Entwicklungsund Debugzwecken entworfen werden kann. Als beispielhafte Implementierung wurden zusammen mit Praktikumsgruppen zwei Anwendungen entwickelt, die im Frühjahr 2005 an der Internationalen RoboCup GermanOpen und im Sommer 2005 an der RoboCup Weltmeisterschaft in der Humanoid League erfolgreich teilnahmen. Abstract The Simulation and Systems Optimization Group of the Department of Computer Science of the Technische Universität Darmstadt concerns itself with the research of mobile autonomous robotic systems. Apart from the hardware and durable algorithms for robotic control the basic software architecture becomes more and more important. In this work a platform-independent framework was developed, which assists to implement a robot control system and a graphic surface for assisting in the development process and for debugging purposes. Two example application were implemented based on that framework together with groups of practical courses, which participated successfully in the Humanoid League at the International RoboCup GermanOpen in spring 2005 and at the RoboCup World championship in summer 2005

D3.3 (M18) - Report on curation in core ELIXIR registries (an ELIXIR Norway ELIXIR3 deliverable)

This report serves as an update on the progress of WP3 Task 3.4 in ELIXIR3, in support of curation efforts on content in repositories of metadata, datasets, tools, training, workflows, and other resources, in line with the ELIXIR Platforms. The report documents progress made, methods used, and plans for the near future as of month 18 of a 48-month timeline. ELIXIR Norway extends support to numerous internal and external service providers in Norway, in cases where the services have been accepted as ELIXIR Services. Being an ELIXIR Service comes with many advantages, from gaining exposure to a broader range of potential users to a raised profile throughout ELIXIR, that can help secure future funding, among other benefits. While these Services maintain specific operational responsibilities, ELIXIR Norway offers versatile infrastructure-related support. We provide a first-line helpdesk, potential Node e-infrastructure integration (where feasible), service monitoring, and metrics collection. Our technology hub further enriches this by imparting best practices and standards, and hosting workshops and conferences. The inception of Task 3.4 is based on observations that most ELIXIR Norway Services do not promote available resources sufficiently, including relevant ontologies, essential repositories like Bio.tools and FAIRsharing, and key Services from other ELIXIR Platforms. The primary objective of the Task is to assist service providers, task forces, and other Tasks and work packages in effectively using available resources for maximum benefit. The work in this Task has been aligned with, and partially builds up on the work performed in the European context in the H2020 project ELIXIR-CONVERGE (February 2020 - July 2023) (871074)