976 research outputs found
Underdeveloped RPE Apical Domain Underlies Lesion Formation in Canine Bestrophinopathies
- Author
- Publication venue
- ScholarlyCommons
- Publication date
- 01/01/2018
- Field of study
Canine bestrophinopathy (cBest) is an important translational model for BEST1-associated maculopathies in man that recapitulates the broad spectrum of clinical and molecular disease aspects observed in patients. Both human and canine bestrophinopathies are characterized by focal to multifocal separations of the retina from the RPE. The lesions can be macular or extramacular, and the specific pathomechanism leading to formation of these lesions remains unclear. We used the naturally occurring canine BEST1 model to examine factors that underlie formation of vitelliform lesions and addressed the susceptibility of the macula to its primary detachment in BEST1-linked maculopathies
Bestrophin1: A Gene that Causes Many Diseases
- Author
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 29/12/2019
- Field of study
Bestrophinopathies are a group of clinically distinct inherited retinal dystrophies that lead to the gradual loss of vision in and around the macular area. There are no treatments for patients suffering from bestrophinopathies, and no measures can be taken to prevent visual deterioration in those who have inherited disease-causing mutations. Bestrophinopathies are caused by mutations in the Bestrophin1 gene (BEST1), a protein found exclusively in the retinal pigment epithelial (RPE) cells of the eye. Mutations in BEST1 affect the function of the RPE leading to the death of overlying retinal cells and subsequent vision loss. The pathogenic mechanisms arising from BEST1 mutations are still not fully understood, and it is not clear how mutations in BEST1 lead to diseases with distinct clinical features. This chapter discusses BEST1, the use of model systems to investigate the effects of mutations and the potential to investigate individual bestrophinopathies using induced pluripotent stem cells
The Outer Tracker Detector of the HERA-B Experiment Part I: Detector
- Author
- A. Donat
- A. Lanyov
- A. Moshkin
- A. Petrukhin
- A. Schreiner
- A. Spiridonov
- A.S. Schwarz
- Albrecht
- Albrecht
- B. Schmidt
- B.X. Chen
- Bagaturia
- Bakker
- Bauer
- Berkhan
- Bruschi
- C. Jiang
- C. Padilla
- C. Stegmann
- Capeáns
- D. Emelianov
- D. Krücker
- D. Pose
- D. Vishnevsky
- E. Michel
- Ehret
- G. Bohm
- G. Evgrafov
- G. Medin
- Gilitsky
- Gorisek
- H. Albrecht
- H. Deckers
- H. Kapitza
- H. Kolanoski
- H. Lüdecke
- H. Schröder
- Hohlmann
- I. Golutvin
- I. Siccama
- I. Tsakov
- I. Vukotic
- J. Ni
- J. Yang
- J.J. Wang
- K. Berkhan
- K. Höpfner
- K. Smirnov
- M. Beck
- M. Bruinsma
- M. Capeans
- M. Hohlmann
- M. Ouchrif
- M. Walter
- N. Tesch
- O. Steinkamp
- R. Eckmann
- R. Mankel
- R. Pernack
- R. Wurth
- R. Zimmermann
- S. Karabekyan
- S. Nowak
- S. Solunin
- S. Somov
- S. Vassiliev
- T. Buran
- T. Lohse
- Th.S. Bauer
- U. Harder
- U. Schwanke
- U. Uwer
- V. Souvorov
- van der Graaf
- W. Hulsbergen
- W. Schmidt-Parzefall
- X. Dong
- Y. Jia
- Y. Kiryushin
- Y.M. Wang
- Y.Q. Liu
- Z. Ke
- Z. Zheng
- Z. Zhu
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2005
- Field of study
The HERA-B Outer Tracker is a large system of planar drift chambers with
about 113000 read-out channels. Its inner part has been designed to be exposed
to a particle flux of up to 2.10^5 cm^-2 s^-1, thus coping with conditions
similar to those expected for future hadron collider experiments. 13
superlayers, each consisting of two individual chambers, have been assembled
and installed in the experiment. The stereo layers inside each chamber are
composed of honeycomb drift tube modules with 5 and 10 mm diameter cells.
Chamber aging is prevented by coating the cathode foils with thin layers of
copper and gold, together with a proper drift gas choice. Longitudinal wire
segmentation is used to limit the occupancy in the most irradiated detector
regions to about 20 %. The production of 978 modules was distributed among six
different laboratories and took 15 months. For all materials in the fiducial
region of the detector good compromises of stability versus thickness were
found. A closed-loop gas system supplies the Ar/CF4/CO2 gas mixture to all
chambers. The successful operation of the HERA-B Outer Tracker shows that a
large tracker can be efficiently built and safely operated under huge radiation
load at a hadron collider.Comment: 28 pages, 14 figure
The Outer Tracker Detector of the HERA-B Experiment. Part II: Front-End Electronics
- Author
- A. Lanyov
- A. Moshkin
- A. Petrukhin
- A. Schreiner
- A. Spiridonov
- A.S. Schwarz
- B. Schmidt
- B.X. Chen
- C. Jiang
- C. Padilla
- C. Stegmann
- D. Emelianov
- D. Krücker
- D. Pose
- D. Ressing
- D. Vishnevsky
- Dam
- E. Michel
- G. Bohm
- G. Evgrafov
- G. Medin
- Geiges
- H. Albrecht
- H. Deckers
- H. Kapitza
- H. Kolanoski
- H. Schröder
- H.J. Wilczek
- I. Golutvin
- I. Siccama
- I. Tsakov
- I. Vukotic
- J. Ni
- J. Yang
- J.J. Wang
- K. Berkhan
- K. Höpfner
- M. Bahte
- M. Beck
- M. Bruinsma
- M. Capeans
- M. Hohlmann
- M. Ouchrif
- M. Pohl
- M. Starič
- M. Walter
- N. Tesch
- Newcomer
- O. Steinkamp
- P. Križan
- R. Eckmann
- R. Loke
- R. Mankel
- R. Pernack
- R. Wurth
- R. Zimmermann
- S. Karabekyan
- S. Korpar
- S. Nowak
- S. Solunin
- S. Somov
- S. Vassiliev
- T. Buran
- T. Lohse
- Th.S. Bauer
- U. Schwanke
- U. Uwer
- V. Souvorov
- W. Hulsbergen
- W. Schmidt-Parzefall
- Williams
- X. Dong
- Y. Jia
- Y. Kiryushin
- Y.M. Wang
- Y.Q. Liu
- Z. Ke
- Z. Zheng
- Z. Zhu
- Publication venue
- 'Elsevier BV'
- Publication date
- 10/12/2004
- Field of study
The HERA-B Outer Tracker is a large detector with 112674 drift chamber
channels. It is exposed to a particle flux of up to 2x10^5/cm^2/s thus coping
with conditions similar to those expected for the LHC experiments. The
front-end readout system, based on the ASD-8 chip and a customized TDC chip, is
designed to fulfil the requirements on low noise, high sensitivity, rate
tolerance, and high integration density. The TDC system is based on an ASIC
which digitizes the time in bins of about 0.5 ns within a total of 256 bins.
The chip also comprises a pipeline to store data from 128 events which is
required for a deadtime-free trigger and data acquisition system. We report on
the development, installation, and commissioning of the front-end electronics,
including the grounding and noise suppression schemes, and discuss its
performance in the HERA-B experiment
Patients with autosomal dominant spinocerebellar ataxia have more risk of falls, important balance impairment, and decreased ability to function
- Author
- Ala A
- Behari M
- Bull PC
- Caca K
- Carolina Yuri P. Aizawa
- Corrêa LS
- Deguti MM
- Ferenci P
- Gupta A
- Gupta A
- Jose Luiz Pedroso
- Kenney SM
- Loudianos G
- Mak CM
- Marilia Rezende Callegari
- Merle U
- Orlando Graziani Povoas Barsottini
- Panagiotakaki E
- Pedro Braga-Neto
- Petrukhin KE
- Schiefermeier M
- Shah AB
- Tanzi RE
- Thomas GR
- Walshe JM
- Yamaguchi Y
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The ever-expanding conundrum of primary osteoporosis: aetiopathogenesis, diagnosis, and treatment
- Author
- A Benet-Pagès
- A Boyde
- A Bruck
- A Forlino
- A Galli-Tsinopoulou
- A Lombardi
- A Nihrane
- A Renaud
- A Saarinen
- A Superti-Furga
- A Zankl
- A Zankl
- AA Deodhar
- AJ Felsenfeld
- AL Dolan
- AM Barnes
- AM Brennan
- AM Lund
- AM Sims
- AN Elias
- B Isidor
- B Lee
- B Moura
- BL Foster
- BP Kelley
- BR Evans
- BT Blumenauer
- C Cepollaro
- C Dall’oca
- C Hofmann
- C Rockman-Greenberg
- C Toomes
- CE Dent
- CK Indumathi
- CL Maslen
- CM Laine
- D Belachew
- D Lev
- D Prié
- D Vega
- D Viljoen
- DH Kok
- DM Brown
- DN Golding
- DN Golding
- DO Sillence
- DP Judge
- E Mornet
- EA Streeten
- ER Barros
- ER Barros
- F Antoniazzi
- F Bayram
- F Gok
- F Rauch
- F Rauch
- F Rauch
- F Rauch
- F Rauch
- F Rauch
- F Rauch
- FE McKiernan
- FH Glorieux
- FJ Ramos
- FS Van Dijk
- G Akler
- G Brunetti
- G Colì
- G Leidig-Bruckner
- G Neuhäuser
- G Saggese
- G Terroso
- GE Krassas
- GI Baroncelli
- GI Baroncelli
- GR Boocock
- GR Mundy
- H Castillo
- H Chen
- H Fleisch
- H Hartikka
- H Nistala
- H Oikawa
- H Somer
- HC Dietz
- HK Marder
- HM Canelas
- HP Arantes
- HP Levy
- IM van der Sluis
- IP Stathopoulos
- J Bacchetta
- J Udell
- J Wendlová
- JB van Meurs
- JC Marini
- JD Picker
- JH Menkes
- JH Tobias
- JJ Bauer
- JJ Westendorf
- JL Vahle
- JL Yen
- JM Gu
- JM Le Parc
- JR Edwards
- JR Gray
- JR Gray
- JS Lim
- JY Lee
- K Avela
- K Nakatsuka
- K Petrukhin
- KA Ward
- KB Gunter
- KB Jonsson
- KE Berkseth
- KE Chad
- KF Janz
- KS Mohammad
- L Beck
- L Folkestad
- L Kohlmeier
- L Kohlmeier
- L Martins
- L Van Wesenbeeck
- LD Quarles
- LE Zionts
- LJ Deftos
- LM Boyden
- LM Downey
- LN Veilleux
- Loredana Cavalli
- M Ai
- M Cheung
- M Christov
- M Frontali
- M Grover
- M Morey
- M Nilsson
- M Teotia
- MA Koay
- MA Simpson
- Maria Luisa Brandi
- Maurizio de Martino
- MB Alcausin
- MJ Henwood
- MK Karlsson
- MK Mäyränpää
- ML Bianchi
- ML Bianchi
- ML Bianchi
- MP Whyte
- MP Whyte
- MP Whyte
- MS Moore
- N Andiran
- N Bishop
- N Bishop
- N Carter
- N Fratzl-Zelman
- N Hajdu
- NJ Shaw
- NS Ma
- O Mäkitie
- P Beighton
- P Beighton
- P Crabbe
- P Pitukcheewanont
- PA Baldock
- PC Bull
- PC Coelho
- PF Giampietro
- PF Giampietro
- PH Byers
- PJ Roughley
- R Baron
- R Leung
- R Mindelzun
- R Rizzoli
- R Sakkers
- RA Mosig
- RA Sutton
- RD Little
- RD Steiner
- RE Brenner
- RF Pfeiffer
- RI Gafni
- RM Shore
- RR McLean
- RS Lorenc
- S Hwang
- S Kanumakala
- S Kutilek
- S Narumi
- S Poyrazoglu
- S Stagi
- S Toiviainen-Salo
- S Yap
- S Zanotti
- SA Bowden
- SA Khan
- SA Polyzos
- SA Temtamy
- Salvatore Seminara
- SH Ralston
- SJ Theodorou
- SL Ferrari
- SM Pyott
- SR Joshi
- SR Phadke
- SS Beck-Nielsen
- Stefano Stagi
- SY Jeong
- T Cundy
- T Cundy
- T Edouard
- T Sousa
- T Tønnesen
- TH Consortium
- U Schwarze
- UE Pazzaglia
- V Datta
- V Nunziata
- VK Yadav
- VK Yadav
- VS Jagtap
- W Sakamoto
- W Traub
- WD Cheney
- WM Cheung
- WR Reinus
- Y Gong
- Y Gong
- Y Narumi
- Y Tang
- Y Uziel
- Z Karim
- ZA Azizi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Adam Bourdarios C
- Adamczyk L
- Adamek L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Ait Tamlihat M
- Aitbenchikh B
- Aizenberg I
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi F
- Algren M
- Alhroob M
- Ali B
- Ali HMJ
- Ali S
- Alibocus SW
- Aliev M
- Alimonti G
- Alkakhi W
- Allaire C
- Allbrooke BMM
- Allen JF
- Allendes Flores CA
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alvarez Estevez M
- Alvarez Fernandez A
- Alves Cardoso M
- Alviggi MG
- Aly M
- Amaral Coutinho Y
- Ambler A
- Amelung C
- Amerl M
- Ames CG
- Amidei D
- Amor Dos Santos SP
- Amos KR
- Ananiev V
- Anastopoulos C
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Anulli F
- Aoki M
- Aoki T
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Appelt C
- Apyan A
- Aranzabal N
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Assamagan K
- Astalos R
- Atashi S
- Atkin RJ
- Atkinson M
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Auriol AD
- Austrup VA
- Avolio G
- Axiotis K
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Bachiu A
- Backman F
- Badea A
- Bagnaia P
- Bahmani M
- Bailey AJ
- Bailey VR
- Baines JT
- Baines L
- Bakalis C
- Baker OK
- Bakos E
- Bakshi Gupta D
- Balakrishnan V
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Baltes LM
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Bansal S
- Barak L
- Barakat M
- Barberio EL
- Barberis D
- Barbero M
- Barel MZ
- Barends KN
- Barillari T
- Barisits M-S
- Barklow T
- Baron Moreno DA
- Baron P
- Baroncelli A
- Barone G
- Barr AJ
- Barr JD
- Barranco Navarro L
- Barreiro Guimarães da Costa J
- Barreiro F
- Barron U
- Barros Teixeira MG
- Barsov S
- Bartels F
- Bartoldus R
- Barton AE
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- Beacham JB
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- Beauchemin PH
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- Beck HP
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- Beddall AJ
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begalli M
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- Behera A
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- Bhamjee M
- Bhatta S
- Bhattacharya DS
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- Bhopatkar VS
- Bi R
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- Buxo Vazquez CJ
- Buzykaev AR
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- Cadamuro L
- Caforio D
- Cai H
- Cai Y
- Cairo VMM
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- Carlson BT
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- Castiglia EG
- Castillo Garcia L
- Castillo Gimenez V
- Castillo FL
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- Cheplakov A
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- Chiarelli G
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- Chitan A
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- Chizhov MV
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- Chwastowski JJ
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- Ciesla KM
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- Ciocio A
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- Corriveau F
- Cortes-Gonzalez A
- Costa MJ
- Costanza F
- Costanzo D
- Cote BM
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- Cranmer K
- Cremonini D
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- Cristoforetti M
- Croft V
- Crosby JE
- Crosetti G
- Crépé-Renaudin S
- Cueto A
- Cuhadar Donszelmann T
- Cui H
- Cui Z
- Cunningham WR
- Curcio F
- Czodrowski P
- Czurylo MM
- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
- Da Via C
- Dabrowski W
- Dado T
- Dahbi S
- Dai T
- Dal Santo D
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- Dandoy JR
- Daneri MF
- Danninger M
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- Darbo G
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- Das SJ
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- Davis-Purcell B
- Dawson I
- Day-hall HA
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- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
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- Zhou Y
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- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
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- Zorbas TG
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- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s = 13 TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Addepalli SV
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
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- Zhemchugov A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and Otq(8), where the limits on the latter are the most stringent to date. [Figure not available: see fulltext.]
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
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- Zhemchugov A
- Zheng J
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- Zimine NI
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Measurement of the energy asymmetry in t(t)over-barj production at 13 TeV with the ATLAS experiment and interpretation in the SMEFT framework
- Author
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- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Aboulhorma A
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- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 28/04/2022
- Field of study
A measurement of the energy asymmetry in jet-associated top-quark pair production is presented using 139fb−1
139
fb
-
1
of data collected by the ATLAS detector at the Large Hadron Collider during pp collisions at s=13TeV
s
=
13
TeV
. The observable measures the different probability of top and antitop quarks to have the higher energy as a function of the jet scattering angle with respect to the beam axis. The energy asymmetry is measured in the semileptonic ttˉ
t
t
¯
decay channel, and the hadronically decaying top quark must have transverse momentum above 350GeV
350
GeV
. The results are corrected for detector effects to particle level in three bins of the scattering angle of the associated jet. The measurement agrees with the SM prediction at next-to-leading-order accuracy in quantum chromodynamics in all three bins. In the bin with the largest expected asymmetry, where the jet is emitted perpendicular to the beam, the energy asymmetry is measured to be −0.043±0.020
-
0.043
±
0.020
, in agreement with the SM prediction of −0.037±0.003
-
0.037
±
0.003
. Interpreting this result in the framework of the Standard Model effective field theory (SMEFT), it is shown that the energy asymmetry is sensitive to the top-quark chirality in four-quark operators and is therefore a valuable new observable in global SMEFT fits
- …