Embolie pulmonaire (apport du scaner multibarrette)

PARIS-BIUM (751062103) / SudocCentre Technique Livre Ens. Sup. (774682301) / SudocSudocFranceF

The anterior tarsal tunnel syndrome: a case Report

peer reviewedLe syndrome tarsien antérieur constitue une neuropathie canalaire rare, impliquant le nerf fibulaire profond, au niveau de son passage sous le rétinaculum inférieur des extenseurs. Régulièrement méconnu, il engendre errance diagnostique et retard de traitement. Nous rapportons le cas d’un patient de 77 ans se plaignant de symptômes d’un syndrome tarsien antérieur, avec douleurs neuropathiques du cou de pied, sans déficit sensitivo-moteur. L’étude électroneuromyographique objective l’atteinte motrice du nerf fibulaire profond. L’IRM de la cheville a mis en évidence une excroissance osseuse millimétrique du pôle supérieur du naviculaire, effectivement irritative pour le nerf fibulaire profond. L’infiltration de l’excroissance du naviculaire a entraîné une réduction partielle et temporaire de la symptomatologie douloureuse. Une intervention chirurgicale de décompression nerveuse a ensuite été envisagée.The anterior tarsal tunnel syndrome is a rare entrapment neuropathy of the deep peroneal nerve beneath the inferior extensor retinaculum of the ankle. It is unrecognized and may lead to misdiagnosis and delayed treatment. We report the case of a 77 years old patient complaining of anterior tarsal tunnel syndrome’s symptoms with neuropathic pain located at the dorsal part of the foot without any sensorimotor loss. The electroneuromyography was in favour of the motor impairment of the deep peroneal nerve. MRI exploration of the ankle showed a millimetric bony overgrowth of the upper pole of the navicular irritative to the deep peroneal nerve. Infiltration at overgrowth of the navicular provided a partial and temporary decrease in pain symptoms. Surgical nerve decompression was then considered

Anterior cruciate ligament surgery in the rabbit

BACKGROUND: Various methods regarding allograft knee replacements have been described. The animal models, which are generally used for this purpose include sheep, dogs, goats, and pigs, and accrue significant costs for study protocols. The authors herein describe an efficient and cost-effective model to study either native or tissue-engineered allografts for anterior cruciate ligament (ACL) replacement in a New Zealand rabbit model with the potential for transgenic and cell migration studies. METHODS: ACL reconstructions were performed in rabbits under general anesthesia. For fresh allograft implantations, two animals were operated in parallel. Each right extensor digitorum longus tendon was harvested and prepared for implantation. After excision of the ACL, tibial and femoral bone tunnels were created to implant each graft in the native ACL position. RESULTS: During a 2-year period, the authors have successfully undertaken this surgery in 61 rabbits and have not noticed any major complications attributed to this surgical technique. In addition, the authors have observed fast recovery in the animals postoperatively. CONCLUSION: The authors recommend this surgical procedure as an excellent model for the study of knee surgery

Association between carpal tunnel syndrome and the five-year incidence of anxiety disorder and depression in adults followed in general practices in Germany

ObjectiveLittle is known about the longitudinal relationship between carpal tunnel syndrome (CTS) and mental health. Therefore, this retrospective cohort study investigated the association between CTS and the five-year incidence of anxiety disorder and depression in adults from Germany.MethodsData from the Disease Analyzer database (IQVIA) were used for the present study. Patients aged ≥18 years diagnosed for the first time with CTS in one of 1284 general practices in Germany in 2005–2020 were included (index date). Individuals without CTS were matched to those with CTS using a propensity score based on age, sex, the mean number of consultations per year during the follow-up, and the index year. In people without CTS, the index date was a randomly selected consultation in 2005–2020.ResultsThere were 75,135 patients with and 75,135 patients without CTS included in the study (mean [SD] age 57.2 [16.5] years; 59.7% women). Within five years of the index date, the incidence of anxiety disorder was 3.9% and 3.6% in the group with and the group without CTS, respectively (log-rank p-valueConclusionCTS was associated with an increased incidence of anxiety disorder and depression in Germany. Further research should identify the mediators involved in these relationships.</p

Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury

Cardiomyocyte proliferation and dedifferentiation have fueled the field of regenerative cardiology in recent years, whereas the reverse process of redifferentiation remains largely unexplored. Redifferentiation is characterized by the restoration of function lost during dedifferentiation. Previously, we showed that ERBB2-mediated heart regeneration has these two distinct phases: transient dedifferentiation and redifferentiation. Here we survey the temporal transcriptomic and proteomic landscape of dedifferentiation–redifferentiation in adult mouse hearts and reveal that well-characterized dedifferentiation features largely return to normal, although elements of residual dedifferentiation remain, even after the contractile function is restored. These hearts appear rejuvenated and show robust resistance to ischemic injury, even 5 months after redifferentiation initiation. Cardiomyocyte redifferentiation is driven by negative feedback signaling and requires LATS1/2 Hippo pathway activity. Our data reveal the importance of cardiomyocyte redifferentiation in functional restoration during regeneration but also protection against future insult, in what could lead to a potential prophylactic treatment against ischemic heart disease for at-risk patients