Non-destructive interferometric characterization of an optical dipole trap

A method for non-destructive characterization of a dipole trapped atomic sample is presented. It relies on a measurement of the phase-shift imposed by cold atoms on an optical pulse that propagates through a free space Mach-Zehnder interferometer. Using this technique we are able to determine, with very good accuracy, relevant trap parameters such as the atomic sample temperature, trap oscillation frequencies and loss rates. Another important feature is that our method is faster than conventional absorption or fluorescence techniques, allowing the combination of high-dynamical range measurements and a reduced number of spontaneous emission events per atom.Comment: 9 pages, 6 figures, submitted to PR

Rare Charm Decays in the Standard Model and Beyond

We perform a comprehensive study of a number of rare charm decays, incorporating the first evaluation of the QCD corrections to the short distance contributions, as well as examining the long range effects. For processes mediated by the $c\to u\ell^+\ell^-$ transitions, we show that sensitivity to short distance physics exists in kinematic regions away from the vector meson resonances that dominate the total rate. In particular, we find that $D\to\pi\ell^+\ell^-$ and $D\to\rho\ell^+\ell^-$ are sensitive to non-universal soft-breaking effects in the Minimal Supersymmetric Standard Model with R-parity conservation. We separately study the sensitivity of these modes to R-parity violating effects and derive new bounds on R-parity violating couplings. We also obtain predictions for these decays within extensions of the Standard Model, including extensions of the Higgs, gauge and fermion sectors, as well as models of dynamical electroweak symmetry breaking.Comment: 45 pages, typos fixed, discussions adde

Rationale and design of a prospective substudy of clinical endpoint adjudication processes within an investigator-reported randomised controlled trial in patients with coronary artery disease: the GLOBAL LEADERS Adjudication Sub-StudY (GLASSY)

pragmatic and superiority randomised controlled trial designed to challenge the current treatment paradigm of dual antiplatelet therapy (DAPT) for 12 months followed by aspirin monotherapy among patients undergoing percutaneous coronary intervention. By design, all study endpoints are investigator reported (IR) and not subject to formal adjudication by an independent Clinical Event Committee (CEC), which may introduce detection, reporting or ascertainment bias. Methods and analysis We designed the GLOBAL LEADERS Adjudication Sub-StudY (GLASSY) to prospectively implement, in a large sample of patients enrolled within the GLOBAL LEADERS trial (7585 of 15 991, 47.5%), an independent adjudication process of reported and unreported potential endpoints, using standardised CEC procedures, in order to assess whether 23-month ticagrelor monotherapy (90mg twice daily) after 1-month DAPT is non-inferior to a standard regimen of DAPT for 12 months followed by aspirin monotherapy for the primary efficacy endpoint of death, nonfatal myocardial infarction, non-fatal stroke or urgent target vessel revascularisation and superior for the primary safety endpoint of type 3 or 5 bleeding according to the Bleeding Academic Research Consortium criteria. This study will comprehensively assess the comparative safety and efficacy of the two tested antithrombotic strategies on CEC-adjudicated ischaemic and bleeding endpoints and will provide insights into the role of a standardised CEC adjudication process on the interpretation of study findings by quantifying the level of concordance between IR-reported and CEC-adjudicated events. Ethics and dissemination GLASSY has been approved by local ethics committee of all study sites and/or by the central ethics committee for the country depending on country-specific regulations. In all cases, they deemed that it was not neces

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

New Acidic Precursor and Acetone-Based Solvent for Fast Perovskite Processing via Proton-Exchange Reaction with Methylamine

A new solvent system for PbI2 based on HI solution in acetone with a low boiling point is proposed. High solubility of PbI2 is caused by the formation of iodoplumbate complexes, and reaches a concentration of 1.6 M. Upon its crystallization metastable solvate phases PbI2∙HI∙n{(CH3)2CO} are formed. The latter allows for their easy deposition on substrates in a form of smooth and uniform thin films by spin-coating. Through a fast acid-base reaction with a gaseous amine, the films of the intermediate phase can be completely converted to single-phase perovskite films. The developed method allows one to form smooth perovskite films with high crystallinity with a thickness up to 1 μm. Due to easy and fast processing, the developed method can be promising for perovskite technology upscaling

Density ripples in expanding low-dimensional gases as a probe of correlations

We investigate theoretically the evolution of the two-point density correlation function of a low-dimensional ultracold Bose gas after release from a tight transverse confinement. In the course of expansion thermal and quantum fluctuations present in the trapped systems transform into density fluctuations. For the case of free ballistic expansion relevant to current experiments, we present simple analytical relations between the spectrum of “density ripples” and the correlation functions of the original confined systems. We analyze several physical regimes, including weakly and strongly interacting one-dimensional (1D) Bose gases and two-dimensional (2D) Bose gases below the Berezinskii-Kosterlitz-Thouless (BKT) transition. For weakly interacting 1D Bose gases, we obtain an explicit analytical expression for the spectrum of density ripples which can be used for thermometry. For 2D Bose gases below the BKT transition, we show that for sufficiently long expansion times the spectrum of the density ripples has a self-similar shape controlled only by the exponent of the first-order correlation function. This exponent can be extracted by analyzing the evolution of the spectrum of density ripples as a function of the expansion time.Physic

Arctic Ocean Mega Project: Paper 3 - Mesozoic to Cenozoic geological evolution

We present an atlas of paleogeographic and paleotectonic maps which documents major events in the Arctic for 0–157 Ma. We demonstrate that the Mendeleev Ridge has a continental basement. The following chronology of events in the history of the Arctic Ocean is proposed: (1) Jurassic: continental rifting in the area of the Sverdrup-Banks basins and in the area of the present-day Canada Basin; a system of continental-margin volcanic belts formed in the region of Chukotka and the Verkhoyansk-Omolon; (2) Berriasian-Barremian: formation of the continental-margin Verkhoyansk-Chukotka Orogen; fast opening of Canada Basin (~133–125 Ma); (3) Aptian-Albian: formation of continental igneous provinces, rifting and magmatism in the area of the Alpha-Mendeleev ridges; rifting in the Ust’-Lena, Anisin, North-Chukchi, Podvodnikov and Toll basins; (4) Cenomanian-Campanian: intraplate magmatism in the area of the Alpha-Mendeleev ridges; (5) Campanian-Maastrichtian: a likely start of compressional deformations in the area of the Chukchi Sea; (6) Paleocene: formation of the continental-margin orogen; continental rifting along the present-day Eurasia Basin and the Ust’-Lena Basin; (7) Early-Middle Eocene: onset of opening of the Eurasia Basin started; (8) Middle-Late Eocene: a major restructuring of paleogeography of the Arctic took place at ca. 45 Ma with subaerial emergence of the Barents and Kara Sea shelves and onset of ultra-slow spreading of the Gakkel Ridge, and start of the epoch of formation of normal and strike-slip faults on the Lomonosov and Alpha-Mendeleev ridges and on the shelves of the Chukchi and East Siberian seas. Paleoclimate is discussed in connection with changes in the paleogeography