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    Π‘Π˜Π€Π˜Π”ΠžΠ“Π•ΠΠΠ«Π• Π‘Π’ΠžΠ™Π‘Π’Π’Π Π‘Π˜ΠžΠ’Π•Π₯ΠΠžΠ›ΠžΠ“Π˜Π§Π•Π‘ΠšΠžΠ“Πž ΠΠΠΠ›ΠžΠ“Π Π›ΠΠšΠ’ΠžΠ€Π•Π Π Π˜ΠΠ Π§Π•Π›ΠžΠ’Π•ΠšΠ

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    Background:Β  Recent research shows that the growth and development of the gastrointestinalΒ  tract of children fed by breast milk is more intense than that of the formula fed, since the human lactoferrin contained in the breast milk is a factor that stimulates cell growth. Therefore, the possibility of using exogenous lactoferrin will be of great importance in the nutrition of infants.Objektive: To study the bifidogenic properties of the biotechnological analogue of human lactoferrin. Methods: Kinetics of growth and CFU titer of bifidobacterial culture in the presence of a biotechnological analogue of human lactoferrin (0,05–5 mg /ml) was determined.Results: It has been shown that different concentrations of the protein can have both a stimulating (for B. bifidum and B. infantis) and inhibitory (for B. longum) effect on the growth of bifidobacteria, which is due to the affinity of lactoferrin binding to them. It seems important to further study the stimulating effect of this protein on the growth of lactobacilli in the intestine of the child.Conclusion:Β  Due to bifidogenic and high bactericidal action, lactoferrin can be effective in feeding newborns.ОбоснованиС.Β Β  НовСйшиС исслСдования  ΠΏΠΎΠΊΠ°Π·Ρ‹Π²Π°ΡŽΡ‚,Β  Ρ‡Ρ‚ΠΎΒ  рост  ΠΈ Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅Β  ΠΆΠ΅Π»ΡƒΠ΄ΠΎΡ‡Π½ΠΎ-ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΎΠ³ΠΎΒ  Ρ‚Ρ€Π°ΠΊΡ‚Π°Β  Π΄Π΅Ρ‚Π΅ΠΉ, вскармливаСмых  матСринским ΠΌΠΎΠ»ΠΎΠΊΠΎΠΌ,Β  происходит  интСнсивнСС,Β  Ρ‡Π΅ΠΌ Ρƒ вскармливаСмых  ΠΌΠΎΠ»ΠΎΡ‡Π½Ρ‹ΠΌΠΈ смСсями, ΠΏΠΎΡΠΊΠΎΠ»ΡŒΠΊΡƒ содСрТащийся Π² Π½Π΅ΠΌ Π»Π°ΠΊΡ‚ΠΎΡ„Π΅Ρ€Ρ€ΠΈΠ½ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° являСтся Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠΌ, ΡΡ‚ΠΈΠΌΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠΌ ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹ΠΉ рост. ИмСнно поэтому Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒΒ  использования экзогСнного Π»Π°ΠΊΡ‚ΠΎΡ„Π΅Ρ€Ρ€ΠΈΠ½Π°Β  Π±ΡƒΠ΄Π΅Ρ‚ ΠΈΠΌΠ΅Ρ‚ΡŒ Π±ΠΎΠ»ΡŒΡˆΡƒΡŽ Π·Π½Π°Ρ‡ΠΈΠΌΠΎΡΡ‚ΡŒ Π² ΠΏΠΈΡ‚Π°Π½ΠΈΠΈ Π³Ρ€ΡƒΠ΄Π½Ρ‹Ρ… Π΄Π΅Ρ‚Π΅ΠΉ.ЦСль  исслСдования β€” ΠΈΠ·ΡƒΡ‡ΠΈΡ‚ΡŒ Π±ΠΈΡ„ΠΈΠ΄ΠΎΠ³Π΅Π½Π½Ρ‹Π΅Β  свойства биотСхнологичСского Π°Π½Π°Π»ΠΎΠ³Π°Β  Π»Π°ΠΊΡ‚ΠΎΡ„Π΅Ρ€Ρ€ΠΈΠ½Π° Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°.ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠžΠΏΡ€Π΅Π΄Π΅Π»ΡΠ»Π°ΡΡŒ ΠΊΠΈΠ½Π΅Ρ‚ΠΈΠΊΠ° роста ΠΈ ΠšΠžΠ•-Ρ‚ΠΈΡ‚Ρ€ ΠΊΡƒΠ»ΡŒΡ‚ΠΈΠ²ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΡ Π±ΠΈΡ„ΠΈΠ΄ΠΎΠ±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΉ Π² присутствии биотСхнологичСского  Π°Π½Π°Π»ΠΎΠ³Π° Π»Π°ΠΊΡ‚ΠΎΡ„Π΅Ρ€Ρ€ΠΈΠ½Π° Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Показано, Ρ‡Ρ‚ΠΎ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Π΅ ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΠΈ Π΄Π°Π½Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° (0,05–5 ΠΌΠ³/ΠΌΠ») ΠΌΠΎΠ³ΡƒΡ‚ ΠΎΠΊΠ°Π·Ρ‹Π²Π°Ρ‚ΡŒ ΠΊΠ°ΠΊ ΡΡ‚ΠΈΠΌΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰Π΅Π΅ (для Bifidobacterium bifidum ΠΈ Bifidobacterium infantis), Ρ‚Π°ΠΊ ΠΈ ΠΈΠ½Π³ΠΈΠ±ΠΈΡ€ΡƒΡŽΡ‰Π΅Π΅ (для Bifidobacterium longum) дСйствиС Π² ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΈ роста Π±ΠΈΡ„ΠΈΠ΄ΠΎΠ±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΉ,Β  Ρ‡Ρ‚ΠΎ обусловлСно Π°Ρ„Ρ„ΠΈΠ½Π½ΠΎΡΡ‚ΡŒΡŽΒ  связывания с Π½ΠΈΠΌΠΈ Π»Π°ΠΊΡ‚ΠΎΡ„Π΅Ρ€Ρ€ΠΈΠ½Π°. ΠŸΡ€Π΅Π΄ΡΡ‚Π°Π²Π»ΡΠ΅Ρ‚ΡΡΒ  Π²Π°ΠΆΠ½Ρ‹ΠΌ дальнСйшСС ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ ΡΡ‚ΠΈΠΌΡƒΠ»ΠΈΡ€ΡƒΡŽΡ‰Π΅Π³ΠΎ эффСкта  этого Π±Π΅Π»ΠΊΠ° Π½Π° рост Π»Π°ΠΊΡ‚ΠΎΠ±Π°Ρ†ΠΈΠ»Π» Π² ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΈΠΊΠ΅ Ρ€Π΅Π±Π΅Π½ΠΊΠ°.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Благодаря Β Π±ΠΈΡ„ΠΈΠ΄ΠΎΠ³Π΅Π½Π½ΠΎΠΌΡƒ ΠΈ Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½ΠΎΠΌΡƒ Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΡ†ΠΈΠ΄Π½ΠΎΠΌΡƒ Π΄Π΅ΠΉΡΡ‚Π²ΠΈΡŽ Π»Π°ΠΊΡ‚ΠΎΡ„Π΅Ρ€Ρ€ΠΈΠ½ ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ использован Π² Π»Π΅Ρ‡Π΅Π±Π½ΠΎΠΌ ΠΏΠΈΡ‚Π°Π½ΠΈΠΈ Π½ΠΎΠ²ΠΎΡ€ΠΎΠΆΠ΄Π΅Π½Π½Ρ‹Ρ…

    BIFIDOGENIC PROPERTIES OF A BIOTECHNOLOGICAL ANALOGUE OF HUMAN LACTOFERRIN

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    Background:Β  Recent research shows that the growth and development of the gastrointestinalΒ  tract of children fed by breast milk is more intense than that of the formula fed, since the human lactoferrin contained in the breast milk is a factor that stimulates cell growth. Therefore, the possibility of using exogenous lactoferrin will be of great importance in the nutrition of infants.Objektive: To study the bifidogenic properties of the biotechnological analogue of human lactoferrin. Methods: Kinetics of growth and CFU titer of bifidobacterial culture in the presence of a biotechnological analogue of human lactoferrin (0,05–5 mg /ml) was determined.Results: It has been shown that different concentrations of the protein can have both a stimulating (for B. bifidum and B. infantis) and inhibitory (for B. longum) effect on the growth of bifidobacteria, which is due to the affinity of lactoferrin binding to them. It seems important to further study the stimulating effect of this protein on the growth of lactobacilli in the intestine of the child.Conclusion:Β  Due to bifidogenic and high bactericidal action, lactoferrin can be effective in feeding newborns
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