Investigating Use of a Parent Report Tool to Measure Vocabulary Development in Deaf Greek-speaking Children with Cochlear Implants

Objective: There are very few measures of language development in spoken Greek that can be used with young deaf children. This study investigated the use of Cyprus Lexical List (CYLEX), a receptive and expressive vocabulary assessment based on parent report that has recently been adapted to Standard Greek, to measure the vocabulary development of deaf Greek-speaking children with cochlear implants. Design: A Standard Greek version of CYLEX was used to collect data on receptive and expressive vocabulary development from parents of thirteen deaf children with cochlear implants aged between 21 and 71 months. These data were compared with data collected previously from typically developing hearing Greek-speaking children. Results: Use of the test by parents of deaf children was found to be reliable. No correlation was found between children's vocabulary scores and chronological age. A positive correlation was however found between children's post-implant age and expressive vocabulary. The vocabulary skills of implanted children with a mean post-implant age of 20 months were not significantly different from those of typically developing hearing children of similar chronological age. Conclusion: CYLEX is a reliable and useful tool for exploring vocabulary development with this clinical group. Findings confirm the results of other studies in indicating that the vocabulary size of implanted pre-school-aged deaf children is related to the amount of time that children have used their implant, rather than chronological age

Anti-cancer effects and mechanism of actions of aspirin analogues in the treatment of glioma cancer

INTRODUCTION: In the past 25 years only modest advancements in glioma treatment have been made, with patient prognosis and median survival time following diagnosis only increasing from 3 to 7 months. A substantial body of clinical and preclinical evidence has suggested a role for aspirin in the treatment of cancer with multiple mechanisms of action proposed including COX 2 inhibition, down regulation of EGFR expression, and NF-κB signaling affecting Bcl-2 expression. However, with serious side effects such as stroke and gastrointestinal bleeding, aspirin analogues with improved potency and side effect profiles are being developed. METHOD: Effects on cell viability following 24 hr incubation of four aspirin derivatives (PN508, 517, 526 and 529) were compared to cisplatin, aspirin and di-aspirin in four glioma cell lines (U87 MG, SVG P12, GOS – 3, and 1321N1), using the PrestoBlue assay, establishing IC50 and examining the time course of drug effects. RESULTS: All compounds were found to decrease cell viability in a concentration and time dependant manner. Significantly, the analogue PN517 (IC50 2mM) showed approximately a twofold increase in potency when compared to aspirin (3.7mM) and cisplatin (4.3mM) in U87 cells, with similar increased potency in SVG P12 cells. Other analogues demonstrated similar potency to aspirin and cisplatin. CONCLUSION: These results support the further development and characterization of novel NSAID derivatives for the treatment of glioma

Promoting speech intelligibility through phonologically dense targets

This multiple baseline single-case study focused on the implementation of two theoretically motivated models relevant to speech sound disorders (SSD): (1) complexity approach and (2) phonological density neighborhood variable. The complexity approach perspective predicted that complex intervention target stimuli would yield greater phonological gains on more complex targets after systematic phonological intervention. Furthermore, phonologically dense targets would promote speech intelligibility as these stimuli 'tax' productive outputs demand on par with complexity approach. A 4; 6 year-old Greek-speaking male diagnosed with a SSD received phonological intervention for 6 months. Therapy goals included: (1) the reduction of phonological process use and (2) the improvement of output intelligibility. Phonological gains were revealed in cluster reduction leading in increases in the proportion of consonant correct use and improvements in the use of correct whole word matches. Phonological gains were observed for untreated word stimuli. Our findings support the synergistic relationship of Complexity Approach and Phonological Density variable in promoting positive speech outcomes and effectiveness of phonological intervention in the child examined

The use of augmentative and alternative communication in Cyprus: Findings from a preliminary survey

Whilst augmentative and alternative communication has been used for over sixty years across many countries, in Cyprus it remains underdeveloped. The current study seeks to investigate the current AAC practices in Cyprus. Data were collected through electronically distributed questionnaires to all registered speech and language therapists (n = 330), contacted by the Cyprus Speech Therapy Association. The questionnaire comprised 12 questions, which were categorized into three sections: background information (educational level and clinical experience), training undergone (during or after completion of tertiary education) and participants’ AAC practices (caseload, assessment and intervention). The findings from the analysis of the returned data (n = 59) reveal that training provision on augmentative and alternative communication has positively influenced practice. Most of the participants received training in the specific field during their bachelor’s degree, rather than during later education. Life-long training on different language systems (including different assistive technology tools, such as symbols and talking products as well as methods such as the Picture Exchange Communication System) also played a pivotal role in their work. Regarding the assessment process, the findings show that whilst there are a number of standardized language assessment tools, the participants relied heavily on non-standardized tools and/or their clinical judgment. Regarding intervention, they reported using different language systems and a variety of Assistive Technology equipment. Several recommendations are made aimed at raising the profile of AAC services in Cyprus, especially with regards to training and assessment, as the findings show that these areas have not been addressed systemically thus far