The development of an unconventional food regeneration process: Quantifying the nutritional components of a model methylotrophic yeast

A hybrid chemical/biological approach to unconventional food regeneration is discussed. Carbon dioxide and water, the major wastes of human metabolism would be converted to methanol by one of several physiochemical processes available (thermal, photocatalytic, etc.). Methanol is then used to supply carbon and energy for the culture of microorganisms which in turn produce biological useful basic food stuffs for human nutrition. Our work has focused on increasing the carbohydrate levels of a candidate methylotrophic yeast to more nearly coincide with human nutritional requirements. Yeasts were chosen due to their high carbohydrate levels compared to bacteria and their present familiarity in the human diet. The initial candidate yeast studied was a thermotolerant strain of Hansenula polymor pha, DL-1. The quantitative results that permit an evaluation of the overall efficiency in hybrid chemical/biological food production schemes are discussed. A preliminary evaluation of the overall efficiency of such schemes is also discussed

An Online Educational Program Improves Pediatric Oncology Nurses’ Knowledge, Attitudes, and Spiritual Care Competence

This study evaluated the potential impact of an online spiritual care educational program on pediatric nurses’ attitudes toward and knowledge of spiritual care and their competence to provide spiritual care to children with cancer at the end of life. It was hypothesized that the intervention would increase nurses’ positive attitudes toward and knowledge of spiritual care and increase nurses’ level of perceived spiritual care competence. A positive correlation was expected between change in nurses’ perceived attitudes toward and knowledge of spiritual care and change in nurses’ perceived spiritual care competence. A prospective, longitudinal design was employed, and analyses included one-way repeated-measures analysis of variance, linear regression, and partial correlation. Statistically significant differences were found in nurses’ attitudes toward and knowledge of spiritual care and nurses’ perceived spiritual care competence. There was a positive relationship between change scores in nurses’ attitudes toward and knowledge of spiritual care and nurses’ spiritual care competence. Online spiritual care educational programs may exert a lasting impact on nurses’ attitudes toward and knowledge of spiritual care and their competence to provide spiritual care to children with cancer at the end of life. Additional studies are required to evaluate the direct effects of educational interventions patient outcomes

Psychosocial and behavioural correlates of attitudes towards antiretroviral therapy (ART) in a sample of South African mineworkers

Despite being one of the worst affected sectors in South Africa, the mining sector has proven to be one of the most active in intervention efforts in the fight against HIV and AIDS (Ellis, 2007). Owing to low uptake rates of antiretroviral therapy (ART) in mining companies in recent years (Connelly & Rosen, 2006) and the positive relationship between attitudes towards ART and ART uptake (Cooper et al., 2002; Horne, Cooper, Gellaitry, Leake, & Fisher, 2007), this study sought to describe and investigate the psychosocial and behavioural correlates of attitudes towards ART in a sample of South African mineworkers. A total of 806 mineworkers from a large South African mine participated in this quantitative study. Despite a high rate of HIV testing behaviour (83.0%) as well as favourable attitudes towards ART, analysis indicated that temporary employees and contractors were more vulnerable in terms of HIV risk, HIV testing behaviours and ART knowledge and attitudes. Employees who had more positive attitudes towards ART were more knowledgeable of ART and, importantly, had a more favourable attitude towards the mine’s HIV/AIDS treatment programme. These findings are discussed in relation to the low ART uptake rates in this context and recommendations for the improvement of ART uptake amongst employees at this mining site.Keywords: mining sector, workplace, ART uptake, attitudes.Le secteur minier reste l’un des secteurs les plus affectés par le VIH et SIDA en Afrique du Sud et aussi l’un des plus actifs dans la lutte contre la maladie (Ellis, 2007). En raison du faible taux d’utilisation de la thérapie antirétrovirale (ART) dans les années récentes par des compagnies minières (Connelly & Rosen, 2006) et les attitudes positives envers ART et ART absorption (Cooper et al., 2002; Horne, Cooper, Gellaitry, Leake, & Fisher, 2007) pour trouver des solutions pour les malades du VIH/SIDA, cette étude á pour objectif d’examiner les comportements psychosociaux et le traitement de la thérapie antirétrovirale d’un groupe de mineurs Sud-Africains. Huit cent six mineurs Sud-Africains ont participé à cette étude quantitative. Soit un taux de dépistage VIH élevé (83.0%) et des attitudes très favorables envers ART, les analyses indiquent qu’en termes de risque du VIH les employés temporaires et les entrepreneurs sont plus exposés á la maladie. Mais cependant, les employés qui sont bien informés de la méthode ART grâce à la connaissance et à l’information bénéficient d’un programme de traitement contre le VIH/SIDA. Ces résultats font l’objet de discussion sur le faible taux d’ART dans ce contexte et quelques recommandations et améliorations de l’absorption de l’ART pour les employés de ce site minier

Verification of State/Event Systems by Quotienting

A rather new approach towards compositional verification of concurrent systems is the quotient technique, where components are gradually removed from the concurrent system while transforming the specification accordingly. When the intermediate specifications can be kept small using heuristics for minimization, the state explosion problemis avoided and there are already promising experimental results for systems with an interleaving semantics, including real-time systems. This paper extends the quotienting approach to deal with a synchronous framework in the shape of state/event systems. A state/event system is a concurrent system with a set of interdependent components operating synchronously according to stimuli (input events) provided by an environment while producing output events in return for the environment. A compositional modal logic M suitable for expressing general safety and liveness properties subsystems is introduced. A quotient construction for building components from a state/event system into the specification is presented and heuristics for minimizing formulae are proposed. The techniques are demonstrated on an example. The correctness of the techniques are justified by proofs in an appendix

Second Overtone Pulsators Among Delta Scuti Stars

We investigate the modal stability of stellar models at masses and luminosity levels corresponding to post main sequence luminous delta scuti pulsators. The envelope models have been computed at fixed mass value, luminosity level and chemical composition (Y=0.28, Z=0.02). According to a nonlinear approach to radial oscillations the present investigation predicts the occurrence of stable second overtone pulsators for the first time. The shape of both light and velocity curves are presented and discussed, providing a useful tool for the identification of second overtone pulsators among the known groups of radially pulsating stars. The period ratios of mixed mode pulsators obtained by perturbing the first and the second overtone radial eigenfunctions are in agreement with observative values. Finally, the physical structure and the dynamical properties of second overtone pulsators are discussed in detail. The role played by the nodal lines in the destabilization of second overtone pulsators is also pointed out.Comment: 20 pages, 11 Postscript figures, uses aaspp4.sty and tighten.st

Metallicities for Double Mode RR Lyrae in the Large Magellanic Cloud

Metallicities for six double mode RR Lyrae's (RRd's) in the Large Magellanic Cloud have been estimated using the DeltaS method. The derived [Fe/H] values are in the range [Fe/H] = -1.09 to -1.78 (or -0.95 to -1.58, adopting a different calibration of [Fe/H] vs DeltaS). Two stars in our sample are at the very metal rich limit of all RRd's for which metal abundance has been estimated, either by direct measure (for field objects) or on the basis of the hosting system (for objects in globular clusters or external galaxies). These metal abundances, coupled with mass determinations from pulsational models and the Petersen diagram, are used to compare the mass-metallicity distribution of field and cluster RR Lyrae variables. We find that field and cluster RRd's seem to follow the same mass-metallicity distribution, within the observational errors, strengthening the case for uniformity of properties between field and cluster variables At odds to what is usually assumed, we find no significative difference in mass for RR Lyrae's in globular clusters of different metallicity and Oosterhoff types, or there may even be a difference contrary to the commonly accepted one, depending on the metallicity scale adopted to derive masses. This ``unusual'' result for the mass-metallicity relation is probably due, at least in part, to the inclusion of updated opacity tables in the computation of metal-dependent pulsation models.Comment: 33 pages, 7 figures, uses aastex, accepted for publication in A

2015 Update on Acute Adverse Reactions to Gadolinium based Contrast Agents in Cardiovascular MR. Large Multi-National and Multi-Ethnical Population Experience With 37788 Patients From the EuroCMR Registry

Objectives: Specifically we aim to demonstrate that the results of our earlier safety data hold true in this much larger multi-national and multi-ethnical population. Background: We sought to re-evaluate the frequency, manifestations, and severity of acute adverse reactions associated with administration of several gadolinium- based contrast agents during routine CMR on a European level. Methods: Multi-centre, multi-national, and multi-ethnical registry with consecutive enrolment of patients in 57 European centres. Results: During the current observation 37788 doses of Gadolinium based contrast agent were administered to 37788 patients. The mean dose was 24.7 ml (range 5–80 ml), which is equivalent to 0.123 mmol/kg (range 0.01 - 0.3 mmol/kg). Forty-five acute adverse reactions due to contrast administration occurred (0.12 %). Most reactions were classified as mild (43 of 45) according to the American College of Radiology definition. The most frequent complaints following contrast administration were rashes and hives (15 of 45), followed by nausea (10 of 45) and flushes (10 of 45). The event rate ranged from 0.05 % (linear non-ionic agent gadodiamide) to 0.42 % (linear ionic agent gadobenate dimeglumine). Interestingly, we also found different event rates between the three main indications for CMR ranging from 0.05 % (risk stratification in suspected CAD) to 0.22 % (viability in known CAD). Conclusions: The current data indicate that the results of the earlier safety data hold true in this much larger multi-national and multi-ethnical population. Thus, the “off-label” use of Gadolinium based contrast in cardiovascular MR should be regarded as safe concerning the frequency, manifestation and severity of acute events

Beat Cepheids as Probes of Stellar and Galactic Metallicity

The mere location of a Beat Cepheid model in a Period Ratio vs. Period diagram (Petersen diagram) puts very tight constraints on its metallicity Z. The Beat Cepheid Peterson diagrams are revisited with linear nonadiabatic turbulent convective models, and their accuracy as a probe for stellar metallicity is evaluated. They are shown to be largely independent of the helium content Y, and they are also only weakly dependent on the mass-luminosity relation that is used in their construction. However, they are found to show sensitivity to the relative abundances of the elements that are lumped into the metallicity parameter Z. Rotation is estimated to have but a small effect on the 'pulsation metallicities'. A composite Petersen diagram is presented that allows one to read off upper and lower limits on the metallicity Z from the measured period P0 and period ratio P1/P0.Comment: 9 pages, 12 color figures (black and white version available from 1st author's website). With minor revisions. to appear in Ap