Seismotectonics of the Eastern Alps: New insights from earthquake studies within 4D-MB

The recent installation of the dense SWATH-D network in the Eastern Alps, integrated into the broader AlpArray, provides the basis for new detailed and consistent studies of small to moderate seismicity. In the SPP project ’From Top to Bottom – Seismicity, motion patterns and stress distribution in the Alpine crust’ and the follow-up project ’Constraints on quaternary processes in the Eastern Alps from a new detailed image of seismicity’, we have focused on event detection, precise location, analysis of seismicity clustering and detailed source parameter studies, involving methodological advancements and subsequent application to the seismological SWATH-D and AlpArray data. Here, we summarize the main results of our completed and ongoing work: 1. We have developed a new, python-based tool for automated station quality control of dense seismic networks and arrays and applied it successfully to the permanent and temporary AlpArray networks as well as to the denser SWATH-D network (AutoStatsQ, [Petersen et al., 2019]). The toolbox uses a combination of observed and synthetic teleseismic event data to identify and quantify errors in amplitude gain and sensor orientation and to correct the stations accordingly. 2. Based on methodological tests adapted for the complex tectonic setting in the Alps, we have performed centroid moment tensor inversion of seismicity with MW ≥ 3.0 recorded by the AlpArray network and compared the solutions to historical earthquakes, recent seismicity, published focal mechanisms, and GNSS deformation data ([Petersen et al., 2021]). We additionally applied epicenter clustering to resolve in detail the heterogeneity of tectonic movement. Thrust faulting is dominant in the Friuli area of the eastern Southern Alps, related to the N–S convergence of the Eurasian and Adriatic plate and counterclockwise rotation of Adria relative to Europe. Strikeslip faulting with similarly oriented P- axes is observed along the northern margin of the Central Alps and in the northern Dinarides, consistent with right-lateral strike-slip faults and high shear strain rates. The NW Alps exhibit deviant behavior, with NW–SE-striking normal faulting events and NE–SW-oriented T- axes. Faulting styles in the SW Alps are more heterogeneous, with a majority of earthquakes related to an extensional stress regime. 3. We have designed a workflow which combines a priori information from local catalog and waveformbased event detection, subsequent GPU-based event search by template matching, P & S arrival time pick refinement and location in a regional 3-D velocity model. Application to the SWATH-D data provided for the first time a consistently processed seismicity catalog for the Eastern and Southern Alps, which has a magnitude of completeness of −1.0 ML, involves event classification and includes > 6, 000 earthquakes [Hofman et al., 2023a]. The newly revealed clusters better illuminate the fault structures at depth, and we detected and located additional, mostly weak events, a part of them pointing to small, but active upper crustal deformation in the Dolomite indenter, along the Pustertal-Gailtal Fault and in the Tauern window. 4. In our ongoing work, we characterize the earthquake distribution in more detail, using novel approaches from Graph theory, waveform similarity based clustering and stacked- waveform moment tensor Inversion [Hofman et al., 2023b], [Petersen et al., 2020], [Petersen et al., 2023]

A MEMS viscometer for unadulterated human blood

The design and theoretical modelling of an oscillating micro-mechanical-viscometer designed for the measurement of whole unadulterated human blood, is described. The proposed device utilises the dependence of the squeeze-film damping ratio on properties of the surrounding fluid to measure fluid viscosity using an oscillating plate structure. The optimum geometrical configuration for the device structure has been investigated and a methodology for defining the optimum configuration of the micro-mechanical sensor identified. This is then applied to calculate the predicted noise equivalent viscosity change . It was found that the device performance is limited by electronic noise within the detection circuitry rather than thermal mechanical noise. An electronic noise limited measurement resolution of , is predicted for measurement over a shear range of , at a measurement bandwidth of . The linearity of response of the micro-mechanical-viscometer is considered and the device is predicted to provide a linear measurement response

Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification

Nonreciprocal translocations and gene amplifications are commonly found in human tumors. Although little is known about the mechanisms leading to such aberrations, tissue culture models predict that they can arise from DNA breakage, followed by cycles of chromatid fusion, asymmetric mitotic breakage, and replication. Mice deficient in both a nonhomologous end joining (NHEJ) DNA repair protein and the p53 tumor suppressor develop lymphomas at an early age harboring amplification of an IgH/c-myc fusion. Here we report that these chromosomal rearrangements are initiated by a recombination activating gene (RAG)-induced DNA cleavage. Subsequent DNA repair events juxtaposing IgH and c-myc are mediated by a break-induced replication pathway. Cycles of breakage-fusion-bridge result in amplification of IgH/c-myc while chromosome stabilization occurs through telomere capture. Thus, mice deficient in NHEJ provide excellent models to study the etiology of unbalanced translocations and amplification events during tumorigenesis

Avaliação e tratamento da dor: avaliação da dor

A dor é o quinto sinal vital, sua avaliação requer reconhecimento dos sinais e dos sintomas que o indivíduo está apresentando. Para tanto, as equipes da área da saúde necessitam de formação permanente no sentido de estarem preparados para realizarem uma avaliação segura. A importância de realizar uma avaliação adequada irá repercutir na implementação dos cuidados para o tratamento.Não é possível instalar um arquivo de vídeo. Apenas transfira-o para seu computador e abra como um arquivo comum. Arquivos de vídeo não podem ser editados, mas podem ser visualizados em players como o VLC Media Player (que é gratuito), o Windows Media Player ou o QuickTime. Os formatos mais comuns de vídeo serão executados normalmente por estes players (avi, mpeg e mp4).VídeoO vídeo é um recurso educativo destinado aos profissionais da área da saúde que necessitam conhecer ou revisar conteúdo sobre a avaliação e o tratamento da dor. Podem ser utilizados de forma individual ou conjuntamente na modalidade a distância ou em modelo híbrido de ensino.1. ed

Avaliação e tratamento da dor: tratamento da dor

A dor é um dos sintomas mais referidos por pacientes adultos hospitalizados. Neste sentido é que as equipes da área da saúde necessitam de formação permanente para realizarem uma avaliação adequada e que proponham um tratamento seguro. Cabe destacar que a adição ao uso de medicamentos analgésicos opióides tem aumentado nos últimos anos e necessita ser revertida.Não é possível instalar um arquivo de vídeo. Apenas transfira-o para seu computador e abra como um arquivo comum. Arquivos de vídeo não podem ser editados, mas podem ser visualizados em players como o VLC Media Player (que é gratuito), o Windows Media Player ou o QuickTime. Os formatos mais comuns de vídeo serão executados normalmente por estes players (avi, mpeg e mp4).VídeoO vídeo é um recurso educativo destinado aos profissionais da área da saúde que necessitam conhecer ou revisar conteúdo sobre a avaliação e o tratamento da dor. Podem ser utilizados de forma individual ou conjuntamente na modalidade a distância ou em modelo híbrido de ensino.1. ed

Is inappropriate left ventricular mass related to neurohormonal factors and/or arterial changes in hypertension? a LIFE substudy

n/