British surname origins, population structure and health outcomes – an observational study of hospital admissions

Population structure is a confounder on pathways linking genotypes to health outcomes. This study examines whether the historical, geographical origins of British surnames are associated with health outcomes today. We coded hospital admissions of over 30 million patients in England between 1999 and 2013 to their British surname origin and divided their diagnoses into 125 major disease categories (of which 94 were complete-case). A base population was constructed with patients’ first admission of any kind. Age- and sex-standardised odds ratios were calculated with logistic regression using patients with ubiquitous English surnames such as “Smith” as reference (alpha = .05; Benjamini–Hochberg false discovery rate (FDR) = .05). The results were scanned for “signals”, where a branch of related surname origins all had significantly higher or lower risk. Age- and sex-standardised admission (alpha = .05) was calculated for each signal across area deprivation and surname origin density quintiles. Signals included three branches of English surnames (disorders of teeth and jaw, fractures, upper gastrointestinal disorders). Although the signal with fractures was considered unusual overall, 2 out of the 9 origins in the branch would only be significant at a FDR > .05: OR 0.92 (95% confidence interval 0.86–0.98) and 0.70 (0.55–0.90). The risk was only different in the quintile with the highest density of that group. Differential risk remained when studied across quintiles of area deprivation. The study shows that surname origins are associated with diverse health outcomes and thus act as markers of population structure over and above area deprivation

Relation of lineaments to sulfide deposits: Bald Eagle Mountain, Centre County, Pennsylvania

The author has identified the following significant results. Discrete areas of finely-fractured and brecciated sandstone float are present along the crest of Bald Mountain and are commonly sites of sulfide mineralization, as evidenced by the presence of barite and limonite gossans. The frequency distributions of the brecciated float as the negative binomial distribution supports the interpretation of a separate population of intensely fractured material. Such zones of concentrated breccia float have an average width of one kilometer with a range from 0.4 to 1.6 kilometers and were observed in a quarry face to have subvertical dips. Direct spatial correlation of the Landsat-derived lineaments to the fractured areas on the ridge is low; however, the mineralized and fracture zones are commonly assymetrical to the lineament positions. Such a systematic dislocation might result from an inherent bias in the float population or could be the product of the relative erosional resistance of the silicified material in the mineralized areas in relation to the erosionally weak material at the stream gaps

Lineaments and Mineral Occurrences in Pennsylvania

The author has identified the following significant results. A conservative lineament map of Pennsylvania interpreted from ERTS-1 channel 7 (infrared) imagery and Skylab photography was compared with the distribution of known metallic mines and mineral occurrences. Of 383 known mineral occurrences, 116 show a geographical association to 1 km wide lineaments, another 24 lie at the intersection of two lineaments, and one lies at the intersection of three lineaments. The Perkiomen Creek lineament in the Triassic Basin is associated with 9 Cu-Fe occurrences. Six Pb-Zn occurrences are associated with the Tyrone-Mount Union lineament. Thirteen other lineaments are associated with 3, 4, or 5 mineral occurrences each

Satellite detection of vegetative damage and alteration caused by pollutants emitted by a zinc smelter

The author has identified the following significant results. Field observations and data collected by low flying aircraft were used to verify the accuracy of maps produced from the satellite data. Although areas of vegetation as small as six acres can accurately be detected, a white pine stand that was severely damaged by sulfur dioxide could not be differentiated from a healthy white pine stand because spectral differences were not large enough. When winter data were used to eliminate interference from herbaceous and deciduous vegetation, the damage was still undetectable. The analysis was able to produce a character map that accurately delineated areas of vegetative alteration due to high zinc levels accumulating in the soil. The map depicted a distinct gradient of less damage and alteration as the distance from the smelter increased. Although the satellite data will probably not be useful for detecting small acreages of damaged vegetation, it is concluded that the data may be very useful as an inventory tool to detect and delineate large vegetative areas possessing differing spectral signatures

Isoperimetric Inequalities for Minimal Submanifolds in Riemannian Manifolds: A Counterexample in Higher Codimension

For compact Riemannian manifolds with convex boundary, B.White proved the following alternative: Either there is an isoperimetric inequality for minimal hypersurfaces or there exists a closed minimal hypersurface, possibly with a small singular set. There is the natural question if a similar result is true for submanifolds of higher codimension. Specifically, B.White asked if the non-existence of an isoperimetric inequality for k-varifolds implies the existence of a nonzero, stationary, integral k-varifold. We present examples showing that this is not true in codimension greater than two. The key step is the construction of a Riemannian metric on the closed four-dimensional ball B with the following properties: (1) B has strictly convex boundary. (2) There exists a complete nonconstant geodesic. (3) There does not exist a closed geodesic in B.Comment: 11 pages, We changed the title and added a section that exhibits the relation between our example and the question posed by Brian White concerning isoperimetric inequalities for minimal submanifold

Some triviality results for quasi-Einstein manifolds and Einstein warped products

In this paper we prove a number of triviality results for Einstein warped products and quasi-Einstein manifolds using different techniques and under assumptions of various nature. In particular we obtain and exploit gradient estimates for solutions of weighted Poisson-type equations and adaptations to the weighted setting of some Liouville-type theorems.Comment: 15 pages, fixed minor mistakes in Section