Book Reviews

Book reviews by Roger Paul Peters, David Bidney, Lester M. Ponder, Edward J. Murphy, Thomas M. Clusserath, and Thomas L. Shaffer

Treatment of Recurrent Intracranial Hemangiopericytoma with SRC-Related Tyrosine Kinase Targeted Therapy: A Case Report

Hemangiopericytoma (HPC) is a rare sarcomatous tumor arising from pericytes, a support cell found in blood vessels. These tumors can occur throughout the body, particularly in the lower extremities and retroperitoneum. In rare circumstances, HPCs can arise from the meninges. In these cases, they behave similar to meningiomas, in particular angiomatous meningiomas, but tend to be more aggressive and are likely to recur. Treatment usually focuses on surgical resection and radiotherapy with possible inclusion of chemotherapy for control of recurrent disease. We describe a case of recurrent right temporal HPC that first manifested as a paraneoplastic syndrome of oncogenic osteomalacia. Despite maximum therapy, this patient experienced multiple recurrences of the tumor, and immunohistochemical analysis revealed overexpression of platelet-derived growth factor receptor, a member of the SRC-related tyrosine kinases. After multiple recurrences, the patient's tumor has been stable with treatment with monotherapy utilizing molecularly targeted therapy to SRC-related tyrosine kinases. This is the first case report of the treatment of recurrent meningeal HPC with molecularly targeted therapy to SRC-related tyrosine kinases

Book Reviews

Book reviews by Roger Paul Peters, Stanley J. Parry, George W. Hazlett, Charles E. Sheedy, and Lawrence J. Latto

Quantitative high-dynamic-range electron diffraction of polar nanodomains in Pb2 ScTaO6

Highly B‐site ordered Pb2ScTaO6 crystals are studied as a function of temperature via dielectric spectroscopy and in situ high‐dynamic‐range electron diffraction. The degree of ordering is examined on the local and macroscopic scale and is determined to be 76%. Novel analysis of the electron diffraction patterns provides structural information with two types of antiferroelectric displacements determined to be present in the polar structure. It is then found that a low‐temperature transition occurs on cooling at ≈210 K that is not present on heating. This phenomenon is discussed in terms of the freezing of dynamic polar nanodomains where a high density of domain walls creates a metastable state

Expansion of Indecency Regulation: Presented by the Federalist Society\u27s Telecommunications Practice Group

This is a transcript of the November 10, 2005, panel discussion at the National Lawyer\u27s Convention presented by the Federalist Society\u27s Telecommunications Practice Group. The panelists debate and discuss the Federal Communications Commission\u27s ( FCC ) regulation of indecent content

Butyrate Supplementation Exacerbates Myocardial and Immune Cell Mitochondrial Dysfunction in a Rat Model of Faecal Peritonitis

Mitochondrial dysfunction and immune cell dysfunction are commonplace in sepsis and are associated with increased mortality risk. The short chain fatty acid, butyrate, is known to have anti-inflammatory effects and promote mitochondrial biogenesis. We therefore explored the immunometabolic effects of butyrate in an animal model of sepsis. Isolated healthy human volunteer peripheral mononuclear cells were stimulated with LPS in the presence of absence of butyrate, and released cytokines measured. Male Wistar rats housed in metabolic cages received either intravenous butyrate infusion or placebo commencing 6 h following faecal peritonitis induction. At 24 h, splenocytes were isolated for high-resolution respirometry, and measurement of mitochondrial membrane potential (MMP), reactive oxygen species (mtROS), and intracellular cytokines (TNF alpha, IL-10) using flow cytometry. Isolated splenocytes from septic and septic butyrate treated rats were stimulated with LPS for 18 h and the effects of butyrate on cytokine release assessed. Ex vivo, butyrate (1.8 mM) reduced LPS-induced TNF alpha (p = 0.019) and IL-10 (p = 0.001) release by human PBMCs. In septic animals butyrate infusion reduced the respiratory exchange ratio (p < 0.001), consistent with increased fat metabolism. This was associated with a reduction in cardiac output (p = 0.001), and increased lactate (p = 0.031) compared to placebo-treated septic animals (p < 0.05). Butyrate treatment was associated with a reduction in splenocyte basal respiration (p = 0.077), proton leak (p = 0.022), and non-mitochondrial respiration (p = 0.055), and an increase in MMP (p = 0.007) and mtROS (p = 0.027) compared to untreated septic animals. Splenocyte intracellular cytokines were unaffected by butyrate, although LPS-induced IL-10 release was impaired (p = 0.039). In summary, butyrate supplementation exacerbates myocardial and immune cell mitochondrial dysfunction in a rat model of faecal peritonitis

Agri-Environmental Policy at the Crossroads: Guideposts on a Changing Landscape

Agri-environmental policy is at a crossroads. Over the past 20 years, a wide range of policies addressing the environmental implications of agricultural production have been implemented at the Federal level. Those policies have played an important role in reducing soil erosion, protecting and restoring wetlands, and creating wildlife habitat. However, emerging agri-environmental issues, evolution of farm income support policies, and limits imposed by trade agreements may point toward a rethinking of agri-environmental policy. This report identifies the types of policy tools available and the design features that have improved the effectiveness of current programs. It provides an indepth analysis of one policy tool that may be an important component of a future policy package-agri-environmental payments. The analysis focuses on issues and tradeoffs that policymakers would face in designing a program of agri-environmental payments.conservation programs, environmental policy, agricultural policy, policy instruments, agricultural program design, soil erosion, nitrogen runoff, Environmental Economics and Policy,

Movement of transplanted adult salmonids in previously inaccessible habitat in the Elwha River

The removal of the Elwha and Glines Canyon Dams on the Elwha River will renew access for anadromous salmonids to 70 miles of high quality habitat located primarily within Olympic National Park. Concurrent dam removals began in 2011, with complete fish passage projected in 2014. While the long-term benefits to anadromous populations are undisputed, release of stored sediment behind the dams is temporarily elevating suspended solids and degrading existing spawning habitat downstream of the Elwha dam. To minimize deleterious effects in the lower river, give populations an early opportunity to spawn and imprint on upstream habitats, and examine the response of anadromous fish to the newly available areas, Chinook and coho salmon and steelhead were moved upstream of Elwha and Glines Canyon dams in 2011 and 2012. We radiotagged and tracked 20 adult Chinook salmon, 47 adult coho salmon, and 37 steelhead to determine spatial and temporal movements and spawning in tributaries and the main stem river. An additional 10 coho and 1 chum salmon were tagged in the lower river and released to continue their migration. Fish movements were monitored using fixed sites and mobile tracking. We also observed substantial volitional fallback and subsequent spawning or migrational movement in the lower river by all both Chinook and coho salmon. Kelting behavior was common in tagged steelhead. We observed coho salmon and steelhead redds in Little River, Indian Creek, the mainstem Elwha River, and side channels of the river. Two Chinook redds were seen in the area upstream of Glines Canyon Dam. Tributaries seeded with adults retained spawers while mainstem releases provided for more exploratory migrational movements. The offspring from these relocated adults will have direct outmigration access to the ocean and the river will be open for upstream migration when they return as adults. Transplanting adult salmonids is labor intensive and requires source populations from downstream for seeding, but can result in spawning activity in new areas and can be managed to include hatchery and wild fish to supplement naturally occurring colonizations