The use of humor by an adolescent with autism spectrum disorder

The aim of this study was to describe the humor use by an 11-year-old adolescent with ASD. Through an iterative coding process to identify a successful, unsuccessful, and neutral rating of instances of humor, we describe how does an adolescent with ASD uses humor and the functions humor serves in his interactions with a friend. We describe the personal and environmental factors that support the successful use of humor. The adolescent used two main types of humor (self-initiated and environmentally-initiated), consisting of two forms (verbal and physical). We describe 12 main behavioral indicators to identify the instances of humor. Humor appeared to sever as a means of engaging his friend and he appeared to be most successful in using humor with his friend when in a familiar environment and engaging in a familiar activity. The implications for future research are discussed

Graphic Warning Labels Elicit Affective and Thoughtful Responses from Smokers: Results of a Randomized Clinical Trial

Objective Observational research suggests that placing graphic images on cigarette warning labels can reduce smoking rates, but field studies lack experimental control. Our primary objective was to determine the psychological processes set in motion by naturalistic exposure to graphic vs. text-only warnings in a randomized clinical trial involving exposure to modified cigarette packs over a 4-week period. Theories of graphic-warning impact were tested by examining affect toward smoking, credibility of warning information, risk perceptions, quit intentions, warning label memory, and smoking risk knowledge. Methods Adults who smoked between 5 and 40 cigarettes daily (N = 293; mean age = 33.7), did not have a contra-indicated medical condition, and did not intend to quit were recruited from Philadelphia, PA and Columbus, OH. Smokers were randomly assigned to receive their own brand of cigarettes for four weeks in one of three warning conditions: text only, graphic images plus text, or graphic images with elaborated text. Results Data from 244 participants who completed the trial were analyzed in structural-equation models. The presence of graphic images (compared to text-only) caused more negative affect toward smoking, a process that indirectly influenced risk perceptions and quit intentions (e.g., image-\u3enegative affect-\u3erisk perception-\u3equit intention). Negative affect from graphic images also enhanced warning credibility including through increased scrutiny of the warnings, a process that also indirectly affected risk perceptions and quit intentions (e.g., image-\u3enegative affect-\u3erisk scrutiny-\u3ewarning credibility-\u3erisk perception-\u3equit intention). Unexpectedly, elaborated text reduced warning credibility. Finally, graphic warnings increased warning-information recall and indirectly increased smoking-risk knowledge at the end of the trial and one month later. Conclusions In the first naturalistic clinical trial conducted, graphic warning labels are more effective than text-only warnings in encouraging smokers to consider quitting and in educating them about smoking’s risks. Negative affective reactions to smoking, thinking about risks, and perceptions of credibility are mediators of their impact

Spin down of protostars through gravitational torques

Young protostars embedded in circumstellar discs accrete from an angular momentum-rich mass reservoir. Without some braking mechanism, all stars should be spinning at or near break-up velocity. In this paper, we perform simulations of the self-gravitational collapse of an isothermal cloud using the ORION adaptive mesh refinement code and investigate the role that gravitational torques might play in the spin-down of the dense central object. While magnetic effects likely dominate for low mass stars, high mass and Population III stars might be less well magnetised. We find that gravitational torques alone prevent the central object from spinning up to more than half of its breakup velocity, because higher rotation rates lead to bar-like deformations that enable efficient angular momentum transfer to the surrounding medium. We also find that the long-term spin evolution of the central object is dictated by the properties of the surrounding disc. In particular, spiral modes with azimuthal wavenumber $m=2$ couple more effectively to its spin than the lopsided $m=1$ mode, which was found to inhibit spin evolution. We suggest that even in the absence of magnetic fields, gravitational torques may provide an upper limit on stellar spin, and that moderately massive circumstellar discs can cause long-term spin down.Comment: 13 pages, 17 figures, 1 table. Accepted by MNRAS. Updated reference

HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis

AbstractIn an effort to determine the specific protein component(s) responsible for in vitro activation of the [FeFe] hydrogenase (HydA), the individual maturation proteins HydE, HydF, and HydG from Clostridium acetobutylicum were purified from heterologous expressions in Escherichia coli. Our results demonstrate that HydF isolated from a strain expressing all three maturation proteins is sufficient to confer hydrogenase activity to purified inactive heterologously expressed HydA (expressed in the absence of HydE, HydF, and HydG). These results represent the first in vitro maturation of [FeFe] hydrogenase with purified proteins, and suggest that HydF functions as a scaffold upon which an H-cluster intermediate is synthesized

Creating objective and measurable postgraduate year 1 residency graduation requirements

PURPOSE: The process of developing objective and measurable postgraduate year 1 (PGY1) residency graduation requirements and a progress tracking system is described. SUMMARY: The PGY1 residency accreditation standard requires that programs establish criteria that must be met by residents for successful completion of the program (i.e., graduation requirements), which should presumably be aligned with helping residents to achieve the purpose of residency training. In addition, programs must track a resident\u27s progress toward fulfillment of residency goals and objectives. Defining graduation requirements and establishing the process for tracking residents\u27 progress are left up to the discretion of the residency program. To help standardize resident performance assessments, leaders of an academic medical center-based PGY1 residency program developed graduation requirement criteria that are objective, measurable, and linked back to residency goals and objectives. A system for tracking resident progress relative to quarterly progress targets was instituted. Leaders also developed a focused, on-the-spot skills assessment termed the Thunderdome, which was designed for objective evaluation of direct patient care skills. Quarterly data on residents\u27 progress are used to update and customize each resident\u27s training plan. Implementation of this system allowed seamless linkage of the training plan, the progress tracking system, and the specified graduation requirement criteria. CONCLUSION: PGY1 residency requirements that are objective, that are measurable, and that attempt to identify what skills the resident must demonstrate in order to graduate from the program were developed for use in our residency program. A system for tracking the residents\u27 progress by comparing residents\u27 performance to predetermined quarterly benchmarks was developed

Factors related to parental age of first concern in toddlers with autism spectrum disorder

PURPOSE: The age of first concern (AOC) of parents of children with autism spectrum disorders (ASD) has substantial implications for early diagnosis and intervention. The current study sought to determine the average AOC, what types of first concerns are most common, and what factors predict earlier AOC in toddlers with ASD. METHODS: This study analyzed the predictive influence of the type of concern, symptom severity, medical diagnoses, and other independent variables on AOC among toddlers with ASD using multiple regressions. RESULTS: The mean AOC was found to be 13.97 months (SD = 7.86). The most commonly reported first concern was speech/language. First concerns related to communication, speech/language predicted later AOC, while motor concerns predicted earlier AOC. CONCLUSIONS: Concerns that are more closely related to social communication deficits characteristic of ASD predicted later AOC. The implications of these findings on screening/assessment and intervention are discussed

Participant Retention Diagram.

<p>Participant recruitment and retention over the course of the trial.</p