Constraints on the depth and geometry of the magma chamber of the Olympus Mons Volcano, Mars

The summit caldera of the Olympus Mons volcano exhibits one of the clearest examples of tectonic processes associated with shield volcanism on Mars. The radial distance from the center of the transition from concentric ridges to concentric graben within the oldest crater provides a constraint on the geometry and depth of the subsurface magmatic reservoir at the time of subsidence. Here, researchers use this constraint to investigate the size, shape, and depth of the reservoir. Their approach consists of calculating radial surface stresses corresponding to the range of subsurface pressure distributions representing an evacuating magma chamber. They then compare stress patterns to the observed radial positions of concentric ridges and graben. The problem is solved by employing the finite element approach using the program TECTON

An investigation of the color reproduction accuracy of two halftoning algorithms for dot matrix systems

The recent popularity of dot matrix printing technologies has renewed interest in developing color halftoning techniques for these systems. A color reproduction scheme based on colorimetric principles would provide accurate color rendition, and can be configured to different hardware implementations. Additionally, where there are demands for multiple copies, color reproduction accuracy is assured to the nth generation. A binary dot matrix halftoning algorithm previously used for black-and-white reproduction (error diffusion) and a new algorithm to be described (EZ method) were investigated in terms of their color reproduction capabilities, with the objective to achieve colorimetric color reproduction. The error diffusion technique made poor system color selections when used in XYZ tristimulus space. As a result, large hue, saturation, and ΔE*ab errors were experienced. The EZ Color Algorithm provided better color accuracy, with an average color difference of less than three for a 4x4 cell size. A uniform color space, such as CIELAB, is considered a minimum requirement in order for the error diffusion algorithm to provide colorimetric color reproduction. Hue, saturation, and ΔE*ab errors were minimized when this color space was used. The EZ Color Algorithm provides several important features including the incorporation of the black colorant explicity in the color formulation, selection of system colors prior to quantizing, and quantization of system color areas instead of reflectance values

Evolution of the Olympus Mons Caldera, Mars

Extensive high-resolution (15 to 20 m/pixel) coverage of Olympus Mons volcano permits the investigation of the sequence of events associated with the evolution of the nested summit caldera. The sequence of the intra-caldera events is well illustrated by image data collected on orbits 473S and 474S of Viking Orbiter 1. These data cover both the oldest and youngest portions of the caldera floor. The chronology inferred from the observations is presented which in turn can be interpreted in terms of the internal structure of the volcano (i.e., magma chamber depth and the existence of dikes)

Libros electrónicos en la Red de Bibliotecas del CSIC. Creación de una colección común

[EN] The collection of digital resources of the CSIC Library Network has been developed mainly for electronic journals. However in the last three years its model for acquisition, management and accessibility applied to journals has been tried to ebooks. The first phase of the introduction of electronic books in the CSIC did not follow a defined strategy. Since 2007 a plan of cooperation has been established within the network in order to create a common collection of quality electronic books. In this article we describe the experience of cooperative purchasing among libraries in the network, the selected collections, how to make them accessible to library patrons, their usage up to now, the investments made and future plans to consolidate the CSIC ebooks collection.[ES] La colección de recursos digitales de la Red de Bibliotecas del CSIC ha estado formada fundamentalmente por revistas electrónicas. Pero en los últimos 3 años el modelo de adquisición, gestión y accesibilidad aplicado a las revistas se ha exportado a los libros electrónicos. La primera fase de la introducción de libros electrónicos en el CSIC no siguió una estrategia definida. Desde 2007 se ha establecido un plan de cooperación dentro de la propia Red que persigue crear una colección común de libros electrónicos de calidad. Se presenta la experiencia de compras cooperativas entre las bibliotecas de la Red, las colecciones seleccionadas, cómo se hacen accesibles a los usuarios, el uso que han tenido, las inversiones realizadas y los planes futuros de consolidación de los libros electrónicos en el CSIC.Peer reviewe

Agenda-Setting in der Blogosphäre? Eine empirische Überprüfung

Auf der Makroebene der Blogosphäre gibt es die sogenannten „A-Blogger“. Diese zeichnen sich dadurch aus, dass ihr Weblog (Blog) im Gegensatz zur großen Mehrheit der Blogs über sehr viele Inlinks-verfügt. In der Literatur sind verschiedene theoretische Ansätze zu finden, die sich mit der Frage beschäftigen, welche Funktion den A-Bloggern in der Blogosphäre zukommt. So wird beispielsweise davon gesprochen, dass sie eine Agenda-Setting-Funktion für die Blogosphäre einnehmen. Das bedeutet, dass sie die in der Blogosphäre diskutierten Themen vorgeben und somit die anderen Blogs, die über deutlich weniger Links verfügen, in deren Themenwahl beeinflussen. Anhand eines Datensatzes (Burton, Java et al. 2009) soll überprüft werden, ob eine Agenda-Setting-Funktion der deutschen A-Blogger für die deutschsprachige Blogosphäre bestätigt werden kann. Als Methode wird die Hyperlinkanalyse eingesetzt

Promoter Recognition by a Complex of Spx and the C-Terminal Domain of the RNA Polymerase α Subunit

Spx, an ArsC (arsenate reductase) family member, is a global transcriptional regulator of the microbial stress response and is highly conserved amongst Gram-positive bacteria. Bacillus subtilis Spx protein exerts positive and negative control of transcription through its interaction with the C-terminal domain of the RNA polymerase (RNAP) alpha subunit (alphaCTD). Spx activates trxA (thioredoxin) and trxB (thioredoxin reductase) in response to thiol stress, and bears an N-terminal C10XXC13 redox disulfide center that is oxidized in active Spx.The structure of mutant Spx(C10S) showed a change in the conformation of helix alpha4. Amino acid substitutions R60E and K62E within and adjacent to helix alpha4 conferred defects in Spx-activated transcription but not Spx-dependent repression. Electrophoretic mobility-shift assays showed alphaCTD interaction with trxB promoter DNA, but addition of Spx generated a supershifted complex that was disrupted in the presence of reductant (DTT). Interaction of alphaCTD/Spx complex with promoter DNA required the cis-acting elements -45AGCA-42 and -34AGCG-31 of the trxB promoter. The Spx(G52R) mutant, defective in alphaCTD binding, did not interact with the alphaCTD-trxB complex. Spx(R60E) not only failed to complex with alphaCTD-trxB, but also disrupted alphaCTD-trxB DNA interaction.The results show that Spx and alphaCTD form a complex that recognizes the promoter DNA of an Spx-controlled gene. A conformational change during oxidation of Spx to the disulfide form likely alters the structure of Spx alpha helix alpha4, which contains residues that function in transcriptional activation and alphaCTD/Spx-promoter interaction. The results suggest that one of these residues, R60 of the alpha4 region of oxidized Spx, functions in alphaCTD/Spx-promoter contact but not in alphaCTD interaction

Cranial shape evolution of extant and fossil crocodile newts and its relation to reproduction and ecology

The diversity of the vertebrate cranial shape of phylogenetically related taxa allows conclusions on ecology and life history. As pleurodeline newts (the genera Echinotriton, Pleurodeles and Tylototriton) have polymorphic reproductive modes, they are highly suitable for following cranial shape evolution in relation to reproduction and environment. We investigated interspecific differences externally and differences in the cranial shape of pleurodeline newts via two-dimensional geometric morphometrics. Our analyses also included the closely related but extinct genus Chelotriton to better follow the evolutionary history of cranial shape. Pleurodeles was morphologically distinct in relation to other phylogenetically basal salamanders. The subgenera within Tylototriton (Tylototriton and Yaotriton) were well separated in morphospace, whereas Echinotriton resembled the subgenus Yaotriton more than Tylototriton. Oviposition site choice correlated with phylogeny and morphology. Only the mating mode, with a random distribution along the phylogenetic tree, separated crocodile newts into two morphologically distinct groups. Extinct Chelotriton likely represented several species and were morphologically and ecologically more similar to Echinotriton and Yaotriton than to Tylototriton subgenera. Our data also provide the first comprehensive morphological support for the molecular phylogeny of pleurodeline newts

Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs

BACKGROUND: The search for an optimal experimental model in pharmacology is recently focused on (mini)pigs as they seem not only to be an alternative source of cells and tissues for xenotherapy but also an alternative species for studies on drug metabolism in man due to similarities between (mini) pig and human drug metabolizing systems. The purpose of this work is to characterize minipig liver microsomal cytochromes P450 (CYPs) by comparing their N-terminal sequences with corresponding human orthologs. RESULTS: The microsomal CYPs exhibit similar activities to their human orthologous enzymes (CYP3A4, nifedipine oxidation; 2A6, coumarin 7-hydroxylation; 2D6, bufuralol 1'-hydroxylation; 2E1, p-nitrophenol hydroxylation; and 2C9, tolbutamide hydroxylation). Specific minipig CYP (2A, 2C and 3A) enzymes were partially purified and proteins identified by immunostaining (using antibodies against the respective human CYPs) were used for N-terminal amino acid sequencing. From comparisons, it can be concluded that the sequence of the first 20 amino acids at the N-terminus of minipig CYP2A is highly similar to human CYP2A6 (70% identity). The N-terminal sequence of CYP2C shared about 50% similarity with human 2C9. The results on the minipig liver microsomal CYP3A yielded identical data with those obtained for amino acid sequences of the pig CYP3A29 showing 60% identity with human CYP3A4. CONCLUSIONS: Thus, our results further support the view that minipigs may serve as model animals in pharmacological/toxicological studies with substrates of human CYP enzymes, namely, of the CYP3A and CYP2A forms

Corn, 1966

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