3,027 research outputs found
The Temperature Dependence of Solar Active Region Outflows
Spectroscopic observations with the EUV Imaging Spectrometer (EIS) on Hinode
have revealed large areas of high speed outflows at the periphery of many solar
active regions. These outflows are of interest because they may connect to the
heliosphere and contribute to the solar wind. In this Letter we use slit
rasters from EIS in combination with narrow band slot imaging to study the
temperature dependence of an active region outflow and show that it is more
complicated than previously thought. Outflows are observed primarily in
emission lines from Fe XI - Fe XV. Observations at lower temperatures (Si VII),
in contrast, show bright fan-like structures that are dominated by downflows.
The morphology of the outflows is also different than that of the fans. This
suggests that the fan loops, which often show apparent outflows in imaging
data, are contained on closed field lines and are not directly related to the
active region outflows.Comment: Movies are available online at:
http://tcrb.nrl.navy.mil/~hwarren/temp/papers/flow_temperatures/ To be
submitted to ApJ
Minimal structural requirements of alkyl Ī³-lactones capable of antagonizing the cocaine-induced motility decrease in planarians
We recently reported that the natural cyclic lactone, parthenolide, and related analogs prevent the expression of behavioral effects induced by cocaine in planarians and that parthenolideās Ī³-lactone ring is required for this effect. In the present work, we tested a series of alkyl Ī³-lactones with varying chain length (1ā8 carbons) to determine their ability to antagonize the planarian motility decrease induced by 200 Ī¼M cocaine. Alkyl lactones with up to a 4-carbon alkyl chain did not affect planarian motility or antagonized the cocaine-induced motility decrease; only the compound Ī³-nonalactone (a Ī³-lactone with a 5-carbon chain) was able to prevent the cocaine-induced behavioral patterns, while alkyl lactones with longer carbon chains failed to prevent the cocaineinduced effects. Thus, we conclude that the optimal structural features of this family of compounds to antagonize cocaineās effect in this experimental system is a Ī³-lactone ring with at a 5-carbon long functional group
Recent Developments in the Use of Flow Hydrogenation in the Field of Medicinal Chemistry
This chapter focuses on recent applications of flow hydrogenation in medicinal chemistry. Flow reactors can enhance laboratory safety, reducing the risks associated with pyrophoric catalysts, due to their containment in catalyst cartridges or omnifit columns. Flow hydrogenation reduces the risks arising from hydrogen gas, with either hydrogen generated in situ from water, or precise management of the gas flow rate through tube-in-tube reactors. There is an increasing body of evidence that flow hydrogenation enhances reduction outcomes across nitro, imine, nitrile, amide, azide, and azo reductions, together with de-aromatisation and hydrodehalogenation. In addition, olefin, alkyne, carbonyl, and benzyl reductions have been widely examined. Further, protocols involving multistage flow reactions involving hydrogenation are highlighted
Improved identification of O-linked glycopeptides from ETD data with optimized scoring for different charge states and cleavage specificities
This article describes the effect of re-interrogation of electron-transfer dissociation (ETD) data with newly developed analytical tools. MS/MS-based characterization of O-linked glycopeptides is discussed using data acquired from a complex mixture of O-linked glycopeptides, featuring mucin core 1-type carbohydrates with and without sialic acid, as well as after partial deglycosylation to leave only the core GalNAc units (Darula and Medzihradszky in Mol Cell Proteomics 8:2515, 2009). Information content of collision-induced dissociation spectra generated in collision cell (in QqTOF instruments) and in ion traps is compared. Interpretation of the corresponding ETD data using Protein Prospector is also presented. Search results using scoring based on the frequency of different fragment ions occurring in ETD spectra of tryptic peptides are compared with results obtained after ion weightings were adjusted to accommodate differential ion frequencies in spectra of differing charge states or cleavage specificities. We show that the improved scoring is more than doubled the glycopeptide assignments under very strict acceptance criteria. This study illustrates that āoldā proteomic data may yield significant new information when re-interrogated with new, improved tools
Gauge conditions for long-term numerical black hole evolutions without excision
Numerical relativity has faced the problem that standard 3+1 simulations of
black hole spacetimes without singularity excision and with singularity
avoiding lapse and vanishing shift fail after an evolution time of around
30-40M due to the so-called slice stretching. We discuss lapse and shift
conditions for the non-excision case that effectively cure slice stretching and
allow run times of 1000M and more.Comment: 19 pages, 14 figures, REVTeX, Added a missing Acknowledgmen
The elevated Curie temperature and half-metallicity in the ferromagnetic semiconductor LaEuO
Here we study the effect of La doping in EuO thin films using SQUID
magnetometry, muon spin rotation (SR), polarized neutron reflectivity
(PNR), and density functional theory (DFT). The SR data shows that the
LaEuO is homogeneously magnetically ordered up to its
elevated . It is concluded that bound magnetic polaron behavior does
not explain the increase in and an RKKY-like interaction is
consistent with the SR data. The estimation of the magnetic moment by DFT
simulations concurs with the results obtained by PNR, showing a reduction of
the magnetic moment per LaEuO for increasing lanthanum doping.
This reduction of the magnetic moment is explained by the reduction of the
number of Eu-4 electrons present in all the magnetic interactions in EuO
films. Finally, we show that an upwards shift of the Fermi energy with La or Gd
doping gives rise to half-metallicity for doping levels as high as 3.2 %.Comment: 7 pages, 11 figure
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