Ice Growth Measurements from Image Data to Support Ice-Crystal and Mixed-Phase Accretion Testing

This paper describes the imaging techniques as well as the analysis methods used to measure the ice thickness and growth rate in support of ice-crystal icing tests performed at the National Research Council of Canada (NRC) Research Altitude Test Facility (RATFac). A detailed description of the camera setup, which involves both still and video cameras, as well as the analysis methods using the NASA Spotlight software, are presented. Two cases, one from two different test entries, showing significant ice growth are analyzed in detail describing the ice thickness and growth rate which is generally linear. Estimates of the bias uncertainty are presented for all measurements. Finally some of the challenges related to the imaging and analysis methods are discussed as well as methods used to overcome them

Reasoning about goal-directed real-time teleo-reactive programs

The teleo-reactive programming model is a high-level approach to developing real-time systems that supports hierarchical composition and durative actions. The model is different from frameworks such as action systems, timed automata and TLA+, and allows programs to be more compact and descriptive of their intended behaviour. Teleo-reactive programs are particularly useful for implementing controllers for autonomous agents that must react robustly to their dynamically changing environments. In this paper, we develop a real-time logic that is based on Duration Calculus and use this logic to formalise the semantics of teleo-reactive programs. We develop rely/guarantee rules that facilitate reasoning about a program and its environment in a compositional manner. We present several theorems for simplifying proofs of teleo-reactive programs and present a partially mechanised method for proving progress properties of goal-directed agents. © 2013 British Computer Society

Coronary heart disease in British soldiers

The aim of this thesis is to present evidence that young soldiers in the British army have a higher mortality from coronary heart disease (CHD) than the civil population from which they derive, and to investigate the causes of this higher mortality, with particular reference to the role of strenuous physical exercise. Chapter One, the introduction, outlines the historical perspective of exercise in populations and individuals. It goes on to describe the attitude of the British army to exercise, both voluntary and compulsory, and to place this in the context of expert and lay opinions on the dangers of exercise. Next follows a historical review of CHD, its risk factors, and its pathology. The body's response to exercise in health and disease is discussed, and finally, the present state of our knowledge on the benefits and risks of exercise. Using data on CHD mortality in the British army culled from the 5 year period 1973-7, and published data from the Office of Population Census and Surveys, the Scottish Home and Health Department, and the Northern Ireland Office, for the same period. Chapter Two compares age specific mortality ratios and concludes that British soldiers under the age of 40 years have a significantly higher, and British officers of all ages a significantly lower mortality from CHD than United Kingdom civilians irrespective of social class. It discovers an inverse relation between CHD mortality and army rank similar to that seen in the civilian social classes, and a trend of diminishing difference in CHD mortality with age between officers and men also similar to that seen in the civilian social classes. The gist of the data was published in the British Medical Journal in 1981

Separation of natural from laboratory-grown diamond using time-gated luminescence imaging

A technique that expands on the surface luminescence imaging used in the DiamondView instrument has been developed at De Beers Group Technology, Maidenhead, UK. This provides an additional level of imaging information by way of separating prompt and delayed surface luminescence. The technique has the added benefit of quickly and easily distinguishing colorless or near-colorless natural diamond from laboratory-grown diamond. It can be applied when the identification of natural diamond is required in the study of single stones, multiples in batches, set jewelry, or in a fully automated process. The prompt and delayed luminescence characteristics of natural diamond are compared with a range of chemical vapor deposition (CVD) and high-pressure, high-temperature (HPHT) synthetic diamonds. Of significant interest are some of the less common CVD synthetic samples that have been observed in recent years. This article will summarize the luminescence observed in different diamond types, discuss its spectral characteristics, and serve as a useful reference when interpreting such luminescence images

Hypothermia: an unusual indication for gastric lavage.

BACKGROUND: Previous reports suggest that gastric lavage holds many risks and is not routinely indicated for decontamination of the overdose patient. OBJECTIVE: To present a case of overdose with concurrent accidental hypothermia where gastric decontamination was utilized. CASE REPORT: A 50-year-old hypothermic, comatose patient was transported to the Emergency Department with a concurrent, massive medication ingestion diagnosed incidentally on a routine abdominal computed tomography scan. Both active and passive rewarming measures, in conjunction with gastric lavage and retrieval of multiple pill fragments, were performed, and the patient survived to hospital discharge without sequelae. Interestingly, the patient admitted to an intentional ingestion of both labetalol and lorazepam. CONCLUSION: Due to hypothermia-mediated changes in metabolism, including gastric atony and decreased hepatic metabolism, gastric lavage may provide additional benefit in the management of severely hypothermic patients with potentially lethal, massive pill ingestions

Application of tandem two-dimensional mass spectrometry for top-down deep sequencing of calmodulin

Two-dimensional mass spectrometry (2DMS) involves simultaneous acquisition of the fragmentation patterns of all the analytes in a mixture by correlating their precursor and fragment ions by modulating precursor ions systematically through a fragmentation zone. Tandem two-dimensional mass spectrometry (MS/2DMS) unites the ultra-high accuracy of Fourier transform ion cyclotron resonance (FT-ICR) MS/MS and the simultaneous data-independent fragmentation of 2DMS to achieve extensive inter-residue fragmentation of entire proteins. 2DMS was recently developed for top-down proteomics (TDP), and applied to the analysis of calmodulin (CaM), reporting a cleavage coverage of about ~23% using infrared multiphoton dissociation (IRMPD) as fragmentation technique. The goal of this work is to expand the utility of top-down protein analysis using MS/2DMS in order to extend the cleavage coverage in top-down proteomics further into the interior regions of the protein. In this case, using MS/2DMS, the cleavage coverage of CaM increased from ~23% to ~42%

A Phase I Trial of Aminolevulinic Acid-Photodynamic Therapy for Treatment of Oral Leukoplakia

Background Photodynamic therapy with aminolevulinic acid (ALA PDT) for oral leukoplakia has shown promising effects in regression of oral leukoplakia. Although ALA has been extensively studied and is an ideal photosensitizer, the optimal light dose for treatment of oral leukoplakia has not been determined. We conducted a phase I study to determine MTD and DLT of PDT in patients treated with ALA for leukoplakia. Methods Patients with histologically confirmed oral leukoplakia received a single treatment of ALA PDT in cohorts with escalating doses of light (585 nm). Clinical, histologic, and biologic markers were assessed. Results Analysis of 11 participants is reported. No significant toxicity from ALA PDT was observed in patients who received ALA with a light dose of up to 4 J/cm2. One participant experienced transient grade 3 transaminase elevation due to ALA. One participant had a partial clinical response 3 months after treatment. Biologic mucosal risk markers showed no significant associations. Determination of MTD could not be accomplished within a feasible timeframe for completion of the study. Conclusions ALA PDT could be safely administered with a light dose up to 4 J/cm2 and demonstrated activity. Larger studies are needed to fully elucidate the MTD and efficacy of ALA-PDT

Winter 1993 observations of oceanography and sediment transport at the LEO-15 site

The NOAA National Underseas Research Program at Rutgers University is establishing a Long-term Ecosystem Observatory off New Jersey in 15 meters of water. As part of a bottom boundary layer study at this site, WHOI deployed a bottom instrument frame during the winter of 1993-94. The bottom instrument carried a current meter, a vertical array of optical back scattering sensors, temperature, pressure and conductivity sensors and an Acoustical Backscattering Sensor. The deployment was partially successful as the acoustic system failed. The other instrumentation worked well for 3 weeks returning data on winter conditions at the site. The extreme winter waves ended the experiment by tipping the instrument over on its side. The optical instrumentation was calibrated with sediment from the site, and the results from the experiment presented.Funding was provided by the National Oceanic and Atmospheric Administration through Contract No. 4-25020 to Rutgers/SUNY National Underseas Research Program

Plant communities affect arbuscular mycorrhizal fungal diversity and community composition in grassland microcosms

The diversity of arbuscular mycorrhizal (AM) fungi was investigated in an unfertilized limestone grassland soil supporting different synthesized vascular plant assemblages that had developed for 3 yr. The experimental treatments comprised: bare soil; monocultures of the nonmycotrophic sedge Carex flacca; monocultures of the mycotrophic grass Festuca ovina; and a species-rich mixture of four forbs, four grasses and four sedges. The diversity of AM fungi was analysed in roots of Plantago lanceolata bioassay seedlings using terminal-restriction fragment length polymorphism (T-RFLP). The extent of AM colonization, shoot biomass and nitrogen and phosphorus concentrations were also measured. The AM diversity was affected significantly by the floristic composition of the microcosms and shoot phosphorus concentration was positively correlated with AM diversity. The diversity of AM fungi in P. lanceolata decreased in the order: bare soil > C. flacca > 12 species > F. ovina. The unexpectedly high diversity in the bare soil and sedge monoculture likely reflects differences in the modes of colonization and sources of inoculum in these treatments compared with the assemblages containing established AM-compatible plants