Uptake and efflux of 64Cu by the marine cyanobacterium Synechococcus (WH7803)

The uptake and efflux of 64Cu was studied in the marine cyanobacterium Synechoccous strain WH7803 (DC2). Uptake followed classical Michaelis-Menten type kinetics in metal-buffered seawater. The maximum uptake rate, Vmax, was 0.236 ± 0.016 × 10-18 mol Cu cell-1 h-1, with the half-saturation constant, KS, of 10-10.81±0.11 mol L-1. An efflux mechanism was also observed in WH7803, whose growth was inhibited by high internal Cu concentrations. Efflux of Cu enabled WH7803 to maintain homeostasis for Cu at typical seawater ambient free copper concentrations ([Cu2+]f). The sensitivity of WH7803 growth to Cu was related to a simple inability to regulate internal Cu concentrations when external concentrations were >10-11 mol L-1

The development of a simple multi-nodal tool to identify performance issues in existing commercial buildings

Australia’s building stock includes many older commercial buildings with numerous factors that impact energy performance and indoor environment quality. The built environment industry has generally focused heavily on improving physical building design elements for greater energy efficiency (such as retrofits and environmental upgrades), however there are noticeable ‘upper limits’ to performance improvements in these areas. To achieve a stepchange improvement in building performance, the authors propose that additional components need to be addressed in a whole of building approach, including the way building design elements are managed and the level of stakeholder engagement between owners, tenants and building managers. This paper focuses on the opportunities provided by this whole-of-building approach, presenting the findings of a research project undertaken through the Sustainable Built Environment National Research Centre (SBEnrc) in Australia. Researchers worked with a number of industry partners over two years to investigate issues facing stakeholders at base building and tenancy levels, and the barriers to improving building performance. Through a mixed-method, industry-led research approach, five ‘nodes’ were identified in whole-of-building performance evaluation, each with interlinking and overlapping complexities that can influence performance. The nodes cover building management, occupant experience, indoor environment quality, agreements and culture, and design elements. This paper outlines the development and testing of these nodes and their interactions, and the resultant multi-nodal tool, called the ‘Performance Nexus’ tool. The tool is intended to be of most benefit in evaluating opportunities for performance improvement in the vast number of existing low-performing building stock

2010-2011 Master Class - Marc Reese and Ken Amis (Brass)

https://spiral.lynn.edu/conservatory_masterclasses/1079/thumbnail.jp

Achievement of combined goals of low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol with three different statins: Results from VOYAGER

AbstractBackgroundGuidelines suggest that the combination of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) is the most clinically relevant goal for lipid-lowering treatments.MethodsData from VOYAGER, an individual patient data meta-analysis including 32,258 patients from 37 clinical trials, was used to determine the percentage of patients reaching combined goals of LDL-C and non-HDL-C following treatment with simvastatin, atorvastatin, or rosuvastatin. Paired comparisons were made between each dose of rosuvastatin and the same or higher doses of simvastatin and atorvastatin.ResultsEach dose of rosuvastatin brought significantly more patients to the combined goal of LDL-C < 100 mg/dL and non-HDL-C < 130 mg/dL than the same or double dose of atorvastatin; atorvastatin 80 mg was significantly superior to rosuvastatin 10 mg (all p < 0.001). Each dose of rosuvastatin helped significantly more patients reach the combined goal than any dose of simvastatin (all p < 0.001), except for rosuvastatin 10 mg versus simvastatin 80 mg (non-significant). Also, each dose of rosuvastatin helped significantly more patients to reach the combined goal of LDL-C < 70 mg/dL and non-HDL-C < 100 mg/dL than the same or double dose of atorvastatin (all p < 0.001). Every dose of rosuvastatin was significantly superior to all doses of simvastatin (all p ≤ 0.020), except for rosuvastatin 10 mg versus simvastatin 40 mg and 80 mg (non-significant).ConclusionsPhysicians' choice of statin and dose is important in helping patients achieve the combined LDL-C and non-HDL-C goals recommended in established guidelines

Introducing the 21st Century Boulevard: A Post-Covid Response to Urban Regeneration of Main Road Corridors,

As city leaders contemplate the post-COVID-19 urban regeneration, Parisian Boulevards from the 17th Century provide inspiration, from their combination of mobility with pedestrian, nature and place-based qualities. This paper proposes a new concept called “21st Century Boulevards” to support local and regional authorities in achieving urban regeneration using such qualities together with new technology. Four approaches are recommended to create 21st Century Boulevards: 1) enhancing road-based shared transit systems such as electric trackless trams; 2) embedding micro-mobility and autonomous shuttles for end-of-trip integration at stations; 3) adopting new precinct-scale technologies that enable Net Zero outcomes for station precincts such as renewable energy recharge hubs, and 4) implementing a smart cities-based demand management system. The human qualities of boulevards are outlined using new planning and design approaches. A key indicator of success would be to measure the extent of a new parameter called the “Busker Factor”. The integration of new technology and new planning to achieve centuries-old urban qualities is a regeneration opportunity with multiple benefits for the main roads of all cities