Clefts and anti-superiority in Moken

We describe an extraction asymmetry in Moken that presents apparent Anti-Superiority effects. We then show that this asymmetry is not rooted in Superiority at all. Evidence from island effects is used to demonstrate that the left-dislocation of wh-phrases is not the result of wh-movement as standardly conceived. Furthermore, the same Anti-Superiority effect obtains for non-wh-phrases and clefts. At the same time, standard Superiority effects in Moken do arise in certain environments. These observations lead to the conclusion that Anti-Superiority effects in Moken are not counterexamples to the universality of Superiority, but instead arise due to a constraint on crossed dependencies between arguments and non-argument positions

Alpha-fetoprotein detection of hepatocellular carcinoma leads to a standardized analysis of dynamic AFP to improve screening based detection

Detection of hepatocellular carcinoma (HCC) through screening can improve outcomes. However, HCC surveillance remains costly, cumbersome and suboptimal. We tested whether and how serum Alpha-Fetoprotein (AFP) should be used in HCC surveillance. Record linkage, dedicated pathways for management and AFP data-storage identified i) consecutive highly characterised cases of HCC diagnosed in 2009–14 and ii) a cohort of ongoing HCC-free patients undergoing regular HCC surveillance from 2009. These two well-defined Scottish patient cohorts enabled us to test the utility of AFP surveillance. Of 304 cases of HCC diagnosed over 6 years, 42% (129) were identified by a dedicated HCC surveillance programme. Of these 129, 47% (61) had a detectable lesion first identified by screening ultrasound (US) but 38% (49) were prompted by elevated AFP. Despite pre-HCC diagnosis AFP >20kU/L being associated with poor outcome, ‘AFP-detected’ tumours were offered potentially curative management as frequently as ‘US-detected’ HCCs; and had comparable survival. Linearity of serial log10-transformed AFPs in HCC cases and in the screening ‘HCC-free’ cohort (n = 1509) provided indicators of high-risk AFP behaviour in HCC cases. An algorithm was devised in static mode, then tested dynamically. A case/control series in hepatitis C related disease demonstrated highly significant detection (p<1.72*10−5) of patients at high risk of developing HCC. These data support the use of AFP in HCC surveillance. We show proof-of-principle that an automated and further refine-able algorithmic interpretation of AFP can identify patients at higher risk of HCC. This approach could provide a cost-effective, user-friendly and much needed addition to US surveillance

Using Interleukin 6 and 8 in Blood and Bronchoalveolar Lavage Fluid to Predict Survival in Hematological Malignancy Patients With Suspected Pulmonary Mold Infection.

Background: Molds and other pathogens induce elevated levels of several cytokines, including interleukin (IL)-6 and IL-8. The objective of this study was to investigate the prognostic value of IL-6 and IL-8 as well as fungal biomarkers in blood and bronchoalveolar lavage fluid (BAL) for overall survival in patients with underlying hematological malignancies and suspected mold infection. Methods: This cohort study included 106 prospectively enrolled adult cases undergoing bronchoscopy. Blood samples were collected within 24 h of BAL sampling and, in a subset of 62 patients, serial blood samples were collected up until 4 days after bronchoscopy. IL-6, IL-8, and other cytokines as well as galactomannan (GM) and β-D-glucan (BDG) were assayed in blood and BAL fluid and associations with overall mortality were assessed at the end of the study using receiver operating characteristic (ROC) curve analysis. Results: Both blood IL-8 (AUC 0.731) and blood IL-6 (AUC 0.699) as well as BAL IL-6 (AUC 0.763) and BAL IL-8 (AUC 0.700) levels at the time of bronchoscopy were predictors of 30-day all-cause mortality. Increasing blood IL-6 levels between bronchoscopy and day four after bronchoscopy were significantly associated with higher 90-day mortality, with similar findings for increasing IL-8 levels. In ROC analysis the difference of blood IL-8 levels between 4 days after bronchoscopy and the day of bronchoscopy had an AUC of 0.829 (95%CI 0.71-0.95; p < 0.001) for predicting 90-day mortality. Conclusions: Elevated levels of IL-6 and IL-8 in blood or BAL fluid at the time of bronchoscopy, and rising levels in blood 4 days following bronchoscopy were predictive of mortality in these patients with underlying hematological malignancy who underwent bronchoscopy for suspected mold infection

Hyperraising from TP in Moro

This paper examines raising out of finite clauses, or hyperraising, in Moro, a Kordofanian language spoken in the Nuba Mountains of Sudan. This paper demonstrates that finite complement clauses that permit hyperraising are TPs. Evidence for this conclusion comes from the unavailability of complementizers, as well as special morphology that is more generally linked to clausal reduction. Parallel facts are shown to obtain for raising from nonfinite clauses, which similarly disallow complementizers. The Moro pattern provides evidence for a general ban on A-movement out of CP in Moro independent of the finiteness of the clause, which is attributed to a CP horizon on φ-probes in Moro, in the framework of Keine (2019, 2020), in conjunction with the claim that Moro is a language without abstract case licensing requirements for DPs

Pronouns, null arguments, and ellipsis in Mandarin Chinese

This paper argues that both overt and null pronouns in Mandarin are the elliptical counterparts of corresponding overt noun phrases. Specifically, null pronouns are the pronominal counterparts of bare nouns, which are typically restricted to unique definite environments, while overt pronouns are the pronominal counterparts of demonstrative descriptions, which are typically restricted to anaphoric definite environments. This result provides support for a hypothesis we call Determiner-Pronoun Parallelism: the idea that a language’s pronominal inventory is isomorphic to its determiners used for the expression of definiteness distinctions

Quantifier Float, Focus, and Scope in Thai

BLS 39: General Session and Special Session on Space and Directionalit

Two kinds of definites in numeral classifier languages

Numeral classifier languages distinguish definite noun phrases licensed by uniqueness from those licensed by familiarity. Unique definites are expressed by bare nouns or null pronouns, while familiar definites are expressed by indexicals such as demonstrative descriptions or overt pronouns. This generalization parallels the observation by Schwarz (2009) that German distinguishes unique versus familiar or anaphoric definiteness in its article system. The difference between the two kinds of definites can be reduced to the presence of a semantic index in the case of familiar definites. As familiar definites occur in most E-type contexts, including donkey anaphora, and uniqueness definites are not possible in these contexts, these facts provide support to dynamic analyses of E-type anaphora and pose problems for uniqueness-based approaches, such as the theory of Elbourne (2013)

Evidence for the Syntactic Diversity of Numeral Classifiers

I propose a syntactic typology of numeral classifier languages based on the observation that the order of nouns and numeral classifiers correlate with substantial differences in the syntactic uses of classifiers. In languages where classifiers precede nouns, they have an article-like use marking definiteness. We take this as evidence that classifiers are functional projections of the NP there, forming a constituent with that noun. In languages where classifiers follow nouns, they do not form a constituent with the head noun, explaining why these languages almost universally exhibit quantifier float of a quantifier+classifier constituent