Propositionalism without propositions, objectualism without objects

Propositionalism is the view that all intentional states are propositional states, which are states with a propositional content, while objectualism is the view that at least some intentional states are objectual states, which are states with objectual contents, such as objects, properties, and kinds. This paper argues that there are two distinct ways of understanding propositionalism and objectualism: (1) as views about the deep nature of the contents of intentional states, and (2) as views about the superficial character of the contents of intentional states. I argue that we should understand the views in the second way. I also argue that the propositionalism debate is fairly independent from debates over the deep nature of intentionality, and that this has implications for arguments for propositionalism and objectualism from claims about the nature of intentional content. I close with a short discussion of how related points apply to the debate over singular content

Asynchronous behavior of outlet glaciers feeding Godthåbsfjord (Nuup Kangerlua) and the triggering of Narsap Sermia's retreat in SW Greenland

We assess ice loss and velocity changes between 1985 and 2014 of three tidewater and fiveland terminating glaciers in Godthabsfjord (Nuup Kangerlua), Greenland. Glacier thinning accounted for 43.8 +/- 0.2 km(3) of ice loss, equivalent to 0.10 mm eustatic sea-level rise. An additional 3.5 +/- 0.3 km(3) was lost to the calving retreats of Kangiata Nunaata Sermia (KNS) and Narsap Sermia (NS), two tidewater glaciers that exhibited asynchronous behavior over the study period. KNS has retreated 22 km from its Little Ice Age (LIA) maximum (1761 AD), of which 0.8 km since 1985. KNS has stabilized in shallow water, but seasonally advects a 2 km long floating tongue. In contrast, NS began retreating from its LIA moraine in 2004-06 (0.6 km), re-stabilized, then retreated 3.3 km during 2010-14 into an over-deepened basin. Velocities at KNS ranged 5-6 km a(-1), while at NS they increased from 1.5 to 5.5 km a(-1) between 2004 and 2014. We present comprehensive analyses of glacier thinning, runoff, surface mass balance, ocean conditions, submarine melting, bed topography, ice melange and conclude that the 2010-14 NS retreat was triggered by a combination of factors but primarily by an increase in submarine melting.We thank W. Dryer and D. Podrasky for assistance with fieldwork and L. Kenefic for assisting with digitizing glacier front positions. CH2 M HILL Polar Services and Air Greenland provided logistics support. The SPOT-5 images used for the 2008 DEM were provided by the SPIRIT program (Centre National d'Etudes Spatiales, France). The DigitalGlobe Worldview images used for the 2014 DEM were obtained from P. Morin. Terminus positions were derived from Landsat images courtesy of the U.S. Geological Survey. Funding was provided by the US National Science Foundation (NSF) Office of Polar Programs (OPP) grants NSF PLR-0909552 and NSF PLR-0909333. Cassotto is supported by NASA under the Earth and Space Science Fellowship Program (Grant NNX14AL29H). K. K. Kjeldsen acknowledges support from the Danish Council Research for Independent Research (grant no. DFF-409000151). K. Kjaer is thanked for his support during the earlier phases of this study. On-ice weather stations are operated by GEUS (Denmark) within the Programme for Monitoring of the Greenland Ice Sheet (PROMICE). J. Mortensen acknowledges support from IIKNN (Greenland), DEFROST project of the Nordic Centre of Excellence program "Interaction between Climate Change and the Cryosphere" and the Greenland Ecosystem Monitoring Programme (www. g-e-m. dk).S. Rysgaard was funded by the Canada Excellence Research Chair Programme. Additional funding was provided by the Geophysical Institute, University of Alaska Fairbanks, and Greenland Climate Research Centre. Scientific editor H. Fricker and reviewers H. Jiskoot and G. Cogley provided very constructive feedback that helped improve the paper.Peer ReviewedRitrýnt tímari

Citizen science informs human-tick exposure in the Northeastern United States

Abstract Background Tick-borne disease is the result of spillover of pathogens into the human population. Traditionally, literature has focused on characterization of tick-borne disease pathogens and ticks in their sylvatic cycles. A limited amount of research has focused on human-tick exposure in this system, especially in the Northeastern United States. Human-tick interactions are crucial to consider when assessing the risk of tick-borne disease since a tick bite is required for spillover to occur. Methods Citizen scientists collected ticks from the Northeastern US through a free nationwide program. Submitted ticks were identified to species, stage, and sex. Blacklegged ticks, Ixodes scapularis, were tested for the presence of Borrelia burgdorferi sensu lato (s.l.) and hard-tick relapsing fever Borrelia. Seasonality of exposure and the citizen science activity during tick exposure was recorded by the citizen scientist. A negative binomial model was fit to predict county level CDC Lyme disease cases in 2016 using citizen science Ixodes scapularis submissions, state, and county population as predictor variables. Results A total of 3740 submissions, comprising 4261 ticks, were submitted from the Northeastern US and were reported to be parasitizing humans. Of the three species submitted, blacklegged ticks were the most prevalent followed by American dog ticks and lone star ticks. Submissions peaked in May with the majority of exposure occurring during every-day activities. The most common pathogen in blacklegged ticks was B. burgdorferi s.l. followed by hard-tick relapsing fever Borrelia. Negative binomial model performance was best in New England states followed by Middle Atlantic states. Conclusions Citizen science provides a low-cost and effective methodology for describing the seasonality and characteristics of human-tick exposure. In the Northeastern US, everyday activities were identified as a major mechanism for tick exposure, supporting the role of peri-domestic exposure in tick-borne disease. Citizen science provides a method for broad pathogen and tick surveillance, which is highly related to human disease, allowing for inferences to be made about the epidemiology of tick-borne disease

Summary of pathogens observed in ticks submitted by citizen scientists across the US [positives/sample size, (percentage prevalence, 95% CI)].

<p>Summary of pathogens observed in ticks submitted by citizen scientists across the US [positives/sample size, (percentage prevalence, 95% CI)].</p

County level distribution of <i>Amblyomma</i> spp.

<p>(A), <i>Dermacentor variabilis</i> (B), <i>D</i>. <i>andersoni</i> and <i>D</i>. <i>occidentalis</i> (C), and <i>Rhipicephalus sanguineus</i> (D) identified following submission from citizen scientists.</p

Primer and probe sets used for the detection of tick-borne pathogens in ticks collected from throughout the US.

<p>Primer and probe sets used for the detection of tick-borne pathogens in ticks collected from throughout the US.</p

Prevalence of <i>A</i>. <i>phagotcytophilum</i>, <i>Bab</i>. <i>microti</i>, <i>B</i>. <i>burgdorferi</i>, and <i>B</i>. <i>miyamotoi</i> for <i>Ixodes scapularis</i> and <i>I</i>. <i>pacificus</i> ticks by state.

<p>Prevalence of <i>A</i>. <i>phagotcytophilum</i>, <i>Bab</i>. <i>microti</i>, <i>B</i>. <i>burgdorferi</i>, and <i>B</i>. <i>miyamotoi</i> for <i>Ixodes scapularis</i> and <i>I</i>. <i>pacificus</i> ticks by state.</p

The county level distribution of <i>I</i>. <i>pacificus</i> and <i>I</i>. <i>scapularis</i> based on location data collected by citizen scientists.

<p>Counties outlined in red did not have previous records according to [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0199644#pone.0199644.ref012" target="_blank">12</a>], no records include travel history of the submitter.</p

Using citizen science to describe the prevalence and distribution of tick bite and exposure to tick-borne diseases in the United States - Fig 1

<p>Submissions to the free tick testing program from across the US (A), starting in January 2017 ending in August of 2017 (B).</p

Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

The concept for cellular immunotherapy of solid tumors relies heavily on the capacity of class I MHC-restricted cytotoxic T lymphocytes (CTLs) to eliminate tumor cells. However, tumors often have managed to escape from the cytolytic machinery of these effector cells. Therefore, it is very important to chart the mechanisms through which this escape can occur. Target-cell killing by CTLs involves the induction of apoptosis by two major mechanisms: through death receptors and the perforin/granzyme B (GrB) pathway. Whereas tumors previously were shown to exhibit mechanisms for blocking the death receptor pathway, we now demonstrate that they also can resist CTL-mediated killing through interference with the perforin/GrB pathway. This escape mechanism involves expression of the serine protease inhibitor PI-9/SPI-6, which inactivates the apoptotic effector molecule GrB. Expression of PI-9 was observed in a variety of human and murine tumors. Moreover, we show that, indeed, expression results in the resistance of tumor cells to CTL-mediated killing both in vitro and in vivo. Our data reveal that PI-9/SPI-6 is an important parameter determining the success of T cell-based immunotherapeutic modalities against cancer