The Zealandia continent: a worthy replacement for Pacifica?

​Citation analysis for papers suggesting a laterally dispersed continent (‘Pacifica’) and a submerged continent in the region of New Caledonia and New Zealand indicates sustained preference for the latter, certainly on geological evidence and probably on biogeographic evidence. However, the name assigned by geologists to this entity – ‘Zealandia’ – is historically inaccurate and politically contentious. A politically acceptable name for the continent that does not kindle post-colonial dissent might be ‘Vallardia’, reflecting the sixteenth century Portuguese maps of the region, but is unlikely to find favour with historians. A solution to this conundrum is to revive the name ‘Pacifica’

Measuring the Effectiveness of New Zealand’s Local Government

Local Government New Zealand’s recently introduced CouncilMARKâ„¢ scheme assesses local councils’ effective management of finance and resources, their leadership and their responsiveness to their communities, and enables them to be compared and the prospect for collaboration towards improved performance explored. Other measures of reputation and ratepayer participation suggest that CouncilMARK may be over-emphasising managerial capability relative to stakeholder engagement, which may have implications for the scheme’s value if community well-being is introduced as a prominent measure of performance

Subjective responses to display bezel characteristics

High quality flat panel computer displays (FPDs) with high resolution screens are now commonplace, and black, grey, white, beige and silver surrounds (‘bezels’), matt or glossy, are in widespread use. It has been suggested that bezels with high reflectance, or with a high gloss, could cause eyestrain, and we have investigated this issue. Twenty office workers (unaware of the study purpose) used six different FPDs, for a week each, at their own desk. These displays were identical apart from the bezel colour (black, white or silver) and shininess (matt or glossy). Participants completed questionnaires about their visual comfort at the end of each week, and were fully debriefed in lunch-time focus groups at the end of the study. For the white and the silver bezels, the glossiness of the bezel was not an issue of concern. The participants were significantly less content with the glossy black surround than with the matt black surround, and in general the glossy black bezel was the least-liked of all those used. With the possible exception of this surround, there was no evidence of significantly increased visual discomfort, indicative of eyestrain, as a result of high or low bezel reflectance, or of high glossiness

Subjective responses to display bezel characteristics

MisericordsBuilt 119

Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines

BackgroundPolymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of key antigens, the impact of polymorphism on potential vaccine escape, and how sequence polymorphism relates to antigenic differences is very limited, yet crucial for vaccine development. Plasmodium falciparum apical membrane antigen 1 (AMA1) is an important target of naturally-acquired antibodies in malaria immunity and a leading vaccine candidate. However, AMA1 has extensive allelic diversity with more than 60 polymorphic amino acid residues and more than 200 haplotypes in a single population. Therefore, AMA1 serves as an excellent model to assess antigenic diversity in malaria vaccine antigens and the feasibility of multi-allele vaccine approaches. While most previous research has focused on sequence diversity and antibody responses in laboratory animals, little has been done on the cross-reactivity of human antibodies.MethodsWe aimed to determine the extent of antigenic diversity of AMA1, defined by reactivity with human antibodies, and to aid the identification of specific alleles for potential inclusion in a multi-allele vaccine. We developed an approach using a multiple-antigen-competition enzyme-linked immunosorbent assay (ELISA) to examine cross-reactivity of naturally-acquired antibodies in Papua New Guinea and Kenya, and related this to differences in AMA1 sequence.ResultsWe found that adults had greater cross-reactivity of antibodies than children, although the patterns of cross-reactivity to alleles were the same. Patterns of antibody cross-reactivity were very similar between populations (Papua New Guinea and Kenya), and over time. Further, our results show that antigenic diversity of AMA1 alleles is surprisingly restricted, despite extensive sequence polymorphism. Our findings suggest that a combination of three different alleles, if selected appropriately, may be sufficient to cover the majority of antigenic diversity in polymorphic AMA1 antigens. Antigenic properties were not strongly related to existing haplotype groupings based on sequence analysis.ConclusionsAntigenic diversity of AMA1 is limited and a vaccine including a small number of alleles might be sufficient for coverage against naturally-circulating strains, supporting a multi-allele approach for developing polymorphic antigens as malaria vaccines

Subjective responses to display bezel characteristics

© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/High quality flat panel computer displays (FPDs) with high resolution screens are now commonplace, and black, grey, white, beige and silver surrounds (‘bezels’), matt or glossy, are in widespread use. It has been suggested that bezels with high reflectance, or with a high gloss, could cause eyestrain, and we have investigated this issue. Twenty office workers (unaware of the study purpose) used six different FPDs, for a week each, at their own desk. These displays were identical apart from the bezel colour (black, white or silver) and shininess (matt or glossy). Participants completed questionnaires about their visual comfort at the end of each week, and were fully debriefed in lunch-time focus groups at the end of the study. For the white and the silver bezels, the glossiness of the bezel was not an issue of concern. The participants were significantly less content with the glossy black surround than with the matt black surround, and in general the glossy black bezel was the least-liked of all those used. With the possible exception of this surround, there was no evidence of significantly increased visual discomfort, indicative of eyestrain, as a result of high or low bezel reflectance, or of high glossiness

A self administered reliable questionnaire to assess lower bowel symptoms

<p>Abstract</p> <p>Background</p> <p>Bowel symptoms are considered indicators of the presence of colorectal cancer and other bowel diseases. Self administered questionnaires that elicit information about lower bowel symptoms have not been assessed for reliability, although this has been done for upper bowel symptoms. Our aim was to develop a self administered questionnaire for eliciting the presence, nature and severity of lower bowel symptoms potentially related to colorectal cancer, and assess its reliability.</p> <p>Methods</p> <p>Immediately before consulting a gastroenterologist or colorectal surgeon, 263 patients likely to have a colonoscopy completed the questionnaire. Reliability was assessed in two ways: by assessing agreement between patient responses and (a) responses given by the doctor at the consultation; and (b) responses given by patients two weeks later.</p> <p>Results</p> <p>There was more than 75% agreement for 78% of the questions for the patient-doctor comparison and for 92% of the questions for the patient-patient comparison. Agreement for the length of time a symptom was present, its severity, duration, frequency of occurrence and whether or not medical consultation had been sought, all had agreement of greater than 70%. Over all questions, the chance corrected agreement for the patient-doctor comparison had a median kappa of 65% (which represents substantial agreement), interquartile range 57–72%. The patient-patient comparison also showed substantial agreement with a median kappa of 75%, interquartile range 68–81%.</p> <p>Conclusion</p> <p>This self administered questionnaire about lower bowel symptoms is a useful way of eliciting details of bowel symptoms. It is a reliable instrument that is acceptable to patients and easily completed. Its use could guide the clinical consultation, allowing a more efficient, comprehensive and useful interaction, ensuring that all symptoms are assessed. It will also be a useful tool in research studies on bowel symptoms and their predictive value for colorectal cancer and other diseases. Studies assessing whether bowel symptoms predict the presence of colorectal cancer should provide estimates of the reliability of the symptom elicitation.</p