Picosecond laser ranging at wavelengths up to 2.4 μm using an InAs avalanche photodiode

Time-of-flight measurements using pulsed laser illumination in the wavelength region between 1.3 to 2.37 μm have been demonstrated with an InAs avalanche photodiode (APD). InAs is photo-sensitive at wavelengths up to 3.5 μm and with predominantly electron multipli- cation reducing detector noise, InAs APDs have clear potential for sen- sitive optical measurements of picosecond transients in the mid-wave infrared. Laboratory-based demonstrations of time-of-flight ranging using InAs APDs operated at room temperature is described

Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent manner

We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor for virus-cell entry and infection. Soluble truncated E2 cloned from a number of diverse HCV genotypes fail to interact with CD81, suggesting that viruses of diverse origin may utilize different receptors and display altered cell tropism. We have used the pseudotyping system to study the tropism of viruses bearing diverse HCV glycoproteins. Viruses bearing these glycoproteins showed a 150-fold range in infectivity for hepatoma cells and failed to infect lymphoid cells. The level of glycoprotein incorporation into particles varied considerably between strains, generally reflecting the E2 expression level within transfected cells. However, differences in glycoprotein incorporation were not associated with virus infectivity, suggesting that infectivity is not limited by the absolute level of glycoprotein. All HCV pseudotypes failed to infect HepG2 cells and yet infected the same cells after transduction to express human CD81, confirming the critical role of CD81 in HCV infection. Interestingly, these HCV pseudotypes differed in their ability to infect HepG2 cells expressing a panel of CD81 variants, suggesting subtle differences in the interaction of CD81 residues with diverse viral glycoproteins. Our current model of HCV infection suggests that CD81, together with additional unknown liver specific receptor(s), mediate the virus-cell entry process

Comparison of the O(3) Bootstrap σ\sigma-Model with the Lattice Regularization at Low Energies

The renormalized coupling \gr defined through the connected 4-point function at zero external momentum in the non-linear O(3) sigma-model in two dimensions, is computed in the continuum form factor bootstrap approach with estimated error $\sim 0.3$. New high precision data are presented for \gr in the lattice regularized theory with standard action for nearly thermodynamic lattices $L/\xi\sim 7$ and correlation lengths $\xi$ up to $\sim 122$ and with the fixed point action for correlation lengths up to $\sim 12$. The agreement between the form factor and lattice results is within $\sim 1$. We also recompute the phase shifts at low energy by measuring the two-particle energies at finite volume, a task which was previously performed by L\"uscher and Wolff using the standard action, but this time using the fixed point action. Excellent agreement with the Zamolodchikov S-matrix is found.Comment: 23 pages, 4 figure

A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa

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Effect of cytomegalovirus infection on breastfeeding transmission of HIV and on the health of infants born to HIV-infected mothers

Cytomegalovirus (CMV) infection can be acquired in utero or postnatally through horizontal transmission and breastfeeding. The effect of postnatal CMV infection on postnatal HIV transmission is unknown

Adherence to extended postpartum antiretrovirals is associated with decreased breast milk HIV-1 transmission

Estimate association between postpartum antiretroviral adherence and breastmilk HIV-1 transmissio