The use of honey in healing a recalcitrant wound following surgical treatment of hidradenitis suppurativa

Ancient civilizations used honey to heal wounds. Despite the rediscovery of honey by modern physicians1 its use in conventional medicine, unlike in complementary medicine, remains limited. Much anecdotal evidence, some clinical observations, some animal models and some randomised controlled trials support the efficacy of honey in managing wounds2,3 , but few detailed descriptions of the use of honey in healing difficult surgical wounds have previously been published

Associating object names with descriptions of shape that distinguish possible from impossible objects.

Five experiments examine the proposal that object names are closely linked torepresentations of global, 3D shape by comparing memory for simple line drawings of structurally possible and impossible novel objects.Objects were rendered impossible through local edge violations to global coherence (cf. Schacter, Cooper, & Delaney, 1990) and supplementary observations confirmed that the sets of possible and impossible objects were matched for their distinctiveness. Employing a test of explicit recognition memory, Experiment 1 confirmed that the possible and impossible objects were equally memorable. Experiments 2–4 demonstrated that adults learn names (single-syllable non-words presented as count nouns, e.g., “This is a dax”) for possible objectsmore easily than for impossible objects, and an item-based analysis showed that this effect was unrelated to either the memorability or the distinctiveness of the individual objects. Experiment 3 indicated that the effects of object possibility on name learning were long term (spanning at least 2months), implying that the cognitive processes being revealed can support the learning of object names in everyday life. Experiment 5 demonstrated that hearing someone else name an object at presentation improves recognition memory for possible objects, but not for impossible objects. Taken together, the results indicate that object names are closely linked to the descriptions of global, 3D shape that can be derived for structurally possible objects but not for structurally impossible objects. In addition, the results challenge the view that object decision and explicit recognition necessarily draw on separate memory systems,with only the former being supported by these descriptions of global object shape. It seems that recognition also can be supported by these descriptions, provided the original encoding conditions encourage their derivation. Hearing an object named at encoding appears to be just such a condition. These observations are discussed in relation to the effects of naming in other visual tasks, and to the role of visual attention in object identification

A multi-criteria, long-term energy planning optimisation model with integrated on-grid and off-grid electrification – The case of Uganda

While electricity access is lowest in developing countries, the academic literature on generation expansion planning (GEP) has been informed almost exclusively by challenges in industrialised countries. This paper presents the first multi-objective, long-term energy planning optimisation model tailored towards national power systems with little existing power infrastructure. It determines the location, type, capacity and timing of power system infrastructure additions. Specifically, three novel generalisations of standard generation planning are introduced: (1) an expansion of the demand constraints to allow for industrial and household electrification rates below 100%, (2) a minimisation of sub-national energy access inequality in conjunction with minimising system costs considering environmental constraints, and (3) an integration of distribution infrastructure, explicitly including both on-grid and off-grid electrification. Using a specifically designed solution algorithm based on the ε-constraint method, the model was successfully applied to the previously unexplored Ugandan national power system case. The results suggest that while it is cost-optimal to maintain highly unequal sub-national access patterns to meet Uganda's official 80% electrification target in 2040, equal access rates across all districts can be achieved by increasing discounted system cost by only 3%. High optimal shares of locationally flexible on-grid and off-grid solar energy enable cheap sub-national shifts of generation capapcity. This paper strongly challenges the Ugandan government's nuclear energy and largely grid-based electrification expansion plans. Instead, it calls for solar concentrated power as a baseload option in the future and a focus on off-grid electrification which the model selects for the majority of household connections in 2040, even in a high-demand scenario.</p

Irreversible reorganization in a supercooled liquid originates from localised soft modes

The transition of a fluid to a rigid glass upon cooling is a common route of transformation from liquid to solid that embodies the most poorly understood features of both phases1,2,3. From the liquid perspective, the puzzle is to understand stress relaxation in the disordered state. From the perspective of solids, the challenge is to extend our description of structure and its mechanical consequences to materials without long range order. Using computer simulations, we show that the localized low frequency normal modes of a configuration in a supercooled liquid are causally correlated to the irreversible structural reorganization of the particles within that configuration. We also demonstrate that the spatial distribution of these soft local modes can persist in spite of significant particle reorganization. The consequence of these two results is that it is now feasible to construct a theory of relaxation length scales in glass-forming liquids without recourse to dynamics and to explicitly relate molecular properties to their collective relaxation.Comment: Published online: 20 July 2008 | doi:10.1038/nphys1025 Available from http://www.nature.com/nphys/journal/v4/n9/abs/nphys1025.htm

“An iron hand in a velvet glove’’: the embodiment of the platform logic in the emergency sector

Despite increasing attention on organizational responses to digital platforms the Information Systems research has overlooked the influence of platforms on the public sector. In this paper we draw on the concept of institutional logics to examine the impact of platforms on the emergency sector. A qualitative case study of the emergency sector is undertaken, comprised of interviews with organizations—including emergency response organizations, government agencies, firms, non-government organizations and community and volunteer groups. The findings reveal the interplay between the prevailing ‘command and control’ and ‘community’ logics and the ‘platform’ logic and how the tensions and synergies between them are shaping the information landscape in the sector. We demonstrate how organizations embody and resist aspects of the platform logic

Serum procalcitonin as an early marker of neonatal sepsis

Background. It has recently been suggested that procalcitonin (PCT) is of value in the diagnosis of neonatal sepsis, with varying results. This study was to evaluate the role of PCT as a single early marker of neonatal sepsis. Setting. Neonatal Unit, Johannesburg Hospital, and Microbiology Laboratory, National Health Laboratory Service (NHLS), South Africa. Subjects and methods. Neonates undergoing evaluation for sepsis between April and August 2002 were eligible for inclusion. Patients were categorised into ‘no infection', ‘possible infection' and ‘definite infection' on the basis of C-reactive protein (CRP), white cell count (WCC), platelet count and blood culture results. PCT was correlated with infection categories. Results. One hundred and eighty-three neonates were enrolled. One hundred and eighteen had no infection, 52 possible infection and 13 definite infection. PCT differed significantly among infection categories (p < 0.0001) and correlated significantly with CRP at presentation (correlation coefficient 0.404, p < 0.001) and CRP at 24 hours (correlation coefficient 0.343, p < 0.001). PCT predicted 89.5% of definite infection. Receiver operating characteristic (ROC) analysis for PCT to predict definite infection showed odds ratio (OR) 1.145 (95% confidence interval (CI): 1.05 - 1.25) with an area under the curve of 0.778. PCT had a negative predictive value of 0.95 (95% CI: 0.915 - 0.988) for definite infection. Conclusions. Although PCT was significantly related to the category of infection, it is not sufficiently reliable to be the sole marker of neonatal sepsis. PCT would be useful as part of a full sepsis evaluation, but is relatively expensive. A negative PCT on presentation may rule out sepsis, but this needs to be evaluated further. S Afr Med J 2004; 94: 851-854

Clinical outcomes for sexual and gender minority adolescents in a dialectical behaviour therapy programme

Background: Sexuality and gender minoritised (SGM) adolescents are at increased risk of self-injury and suicide, and experience barriers to accessing mental health support. Dialectical behaviour therapy (DBT) is an effective treatment for self-injury and emotion dysregulation in adolescent populations, but few studies have published outcomes of DBT for SGM young people. Aims: This study aimed to investigate treatment outcomes and completion for SGM adolescents and their cisgender and heterosexual peers, in the National & Specialist CAMHS, DBT service (UK). Method: Treatment completion, and opting out before and during treatment were examined for sexual and gender identity groups, as well as changes by the end of treatment in emotion dysregulation, self-injury, in-patient bed-days, emergency department attendances, and borderline personality disorder, depression and anxiety symptoms. Results: SGM adolescents were over-represented in this service, even after considering their increased risk for self-injury. No statistically significant differences were found for treatment completion between the sexual orientation and gender identity groups, although there were patterns indicating possible lower treatment uptake and completion that warrant further investigation. Clinical outcomes for treatment-completers showed improvement by the end of DBT for each group, with few exceptions. Discussion: These results are from relatively small subsamples, and it was not possible to separate by sex assigned at birth. Findings should be treated tentatively and as early indications of effect sizes to inform future studies. This study suggests that DBT could be a useful treatment for SGM adolescents in a highly specialist treatment setting

Morphologies of Galaxies in and around a Protocluster at z=2.300

We present results from the first robust investigation of galaxy morphology as a function of environment at z>1.5. Our study is motivated by the fact that star-forming galaxies contained within a protocluster at z=2.3 in the HS1700+64 field have significantly older ages and larger stellar masses on average than those at similar redshifts but more typical environmental densities. In the analysis of HST/ACS images, we apply non-parametric statistics to characterize the rest-frame UV morphologies of a sample of 85 UV-selected star-forming galaxies at z=1.7-2.9, 22 of which are contained in the protocluster. The remaining 63 control-sample galaxies are not in the protocluster but have a similar mean redshift of ~2.3. We find no environmental dependence for the distributions of morphological properties. Combining the measured morphologies with the results of population synthesis modeling, we find only weak correlations, if any, between morphological and stellar population properties such as stellar mass, age, extinction and star-formation rate. Given the incomplete census of the protocluster galaxy population, and the lack of correlation between rest-frame UV morphology and star-formation history at z~2 within our sample, the absence of environmental trends in the distribution of morphological properties is not surprising. Additionally, using a larger sample of photometric candidates, we compare morphological distributions for 282 UV-selected and 43 near-IR-selected galaxies. While the difference in the degree of nebulosity between the two samples appears to be a byproduct of the fainter average rest-frame UV surface brightness of the near-IR-selected galaxies, we find that, among the lowest surface brightness galaxies, the near-IR-selected objects have significantly smaller angular sizes (abridged).Comment: 25 pages including 16 figures. Accepted for publication in ApJ. Version with full resolution figures available at http://www.astro.princeton.edu/~apeter/LBG/papers/peter2007_fullres.ps.g