Merging of globular clusters within inner galactic regions. II. The Nuclear Star Cluster formation

In this paper we present the results of two detailed N-body simulations of the interaction of a sample of four massive globular clusters in the inner region of a triaxial galaxy. A full merging of the clusters takes place, leading to a slowly evolving cluster which is quite similar to observed Nuclear Clusters. Actually, both the density and the velocity dispersion profiles match qualitatively, and quantitatively after scaling, with observed features of many nucleated galaxies. In the case of dense initial clusters, the merger remnant shows a density profile more concentrated than that of the progenitors, with a central density higher than the sum of the central progenitors central densities. These findings support the idea that a massive Nuclear Cluster may have formed in early phases of the mother galaxy evolution and lead to the formation of a nucleus, which, in many galaxies, has indeed a luminosity profile similar to that of an extended King model. A correlation with galactic nuclear activity is suggested.Comment: 18 pages, 10 figures, 3 tables. Submitted to ApJ, main journa

Direct UV observations of the circumstellar envelope of alpha Orionis

Observations were made in the IUE LWP camera, low dispersion mode, with alpha Ori being offset various distances from the center of the Long Wavelength Large Aperture along its major axis. Signal was acquired at all offset positions and is comprised of unequal components of background/dark counts, telescope-scattered light, and scattered light emanating from the extended circumstellar shell. The star is known from optical and infrared observations to possess an extended, arc-minute sized, shell of cool material. Attempts to observe this shell with the IUE are described, although the deconvolution of the stellar signal from the telescope scattered light requires further calibration effort

ASCA and contemporaneous ground-based observations of the BL Lacertae objects 1749+096 and 2200+420 (BL Lac)

We present ASCA observations of the radio-selected BL Lacertae objects 1749+096 (z=0.32) and 2200+420 (BL Lac, z=0.069) performed in 1995 Sept and Nov, respectively. The ASCA spectra of both sources can be described as a first approximation by a power law with photon index Gamma ~ 2. This is flatter than for most X-ray-selected BL Lacs observed with ASCA, in agreement with the predictions of current blazar unification models. While 1749+096 exhibits tentative evidence for spectral flattening at low energies, a concave continuum is detected for 2200+420: the steep low-energy component is consistent the high-energy tail of the synchrotron emission responsible for the longer wavelengths, while the harder tail at higher energies is the onset of the Compton component. The spectral energy distributions from radio to gamma-rays are consistent with synchrotron-self Compton emission from a single homogeneous region shortward of the IR/optical wavelengths, with a second component in the radio domain related to a more extended emission region. For 2200+420, comparing the 1995 Nov state with the optical/GeV flare of 1997 July, we find that models requiring inverse Compton scattering of external photons provide a viable mechanism for the production of the highest (GeV) energies during the flare. An increase of the external radiation density and of the power injected in the jet can reproduce the flat gamma-ray continuum observed in 1997 July. A directly testable prediction of this model is that the line luminosity in 2200+420 should vary shortly after (~1 month) a non-thermal synchrotron flare.Comment: 28 pages,6 figures, 5 tables; LaTeX document. accepted for publication in the Astrophysical Journa

INTRA-DUODENAL RELEASE OF A BITTER COMPOUND DECREASES CALORIC INTAKE IN HEALTHY VOLUNTEERS

Background and aim: α-gustducin and bitter taste receptors (T2R) are expressed both in the oral cavity and in the gastrointestinal (GI) tract. Experimental data showed that bitter tastants induce the release of gut hormones from enteroendocrine cells in the gut, suggesting a possible role of bitter taste receptors in the control of food intake and GI functions. We aimed to test the effects of a bitter taste receptor agonist on food intake and GI feelings. Material and methods: We enrolled 19 healthy subjects (9 males, age 27±7, BMI 24±6) in a double-blind placebo controlled study. Each subject randomly received an acid-resistant capsule containing placebo or 18 mg of quinine HCl. 60 minutes after capsule administration, the subjects underwent to an ad libitum test, until the maximum satiation. Meal test was composed by white bread, cheese and meat cream (89 kcal/portion: 50% carbohydrate, 31% fat, 19% protein). Caloric intake, meal duration and satiation levels, scored on a Visual Analogue Scale (VAS) were calculated at the end of the meal test. A questionnaire assessing GI sensations (bloating, fullness, nausea, epigastric discomfort and hunger) was administered before and at the end of the test. Data (mean ± SD) were compared by using paired t test. Results: No oral bitter sensation or side effects was observed both with quinine HCland placebo. No significant differences in terms of GI sensations and hunger feelings were observed between the two sessions of the study. The amount of calories ingested was significantly lower when subjects received quinine HCl than placebo (564±262 vs 667±278 kcal; p=0.02). Conversely, quinine HCl did not affect the meal duration (14.4±4.2 vs 16.6±4.6 min; p=NS) and the satiationintensity (82 vs 82 mm; p=NS). Conclusions: The intra-duodenal release of a bitter compound significantly decreases caloric intake in an ad libitum test meal without affecting GI sensations and hunger feeling. As the bitter compound does not influence meal duration, we hypothesize that quinine HCl decreases the caloric intake by affecting the rate of meal portions consumption. Evaluation of gut hormones kinetics and studies with other bitter taste receptor agonist are needed to establish the role of gastrointestinal bitter taste receptor in the control of food intak

Stem-like and highly invasive prostate cancer cells expressing CD44v8-10 marker originate from CD44-negative cells

In human prostate cancer (PCa), the neuroendocrine cells, expressing the prostate cancer stem cell (CSC) marker CD44, may be resistant to androgen ablation and promote tumor recurrence. During the study of heterogeneity of the highly aggressive neuroendocrine PCa cell lines PC3 and DU-145, we isolated and expanded in vitro a minor subpopulation of very small cells lacking CD44 (CD44neg). Unexpectedly, these sorted CD44neg cells rapidly and spontaneously converted to a stable CD44high phenotype specifically expressing the CD44v8-10 isoform which the sorted CD44high subpopulation failed to express. Surprisingly and potentially interesting, in these cells expression of CD44v8-10 was found to be induced in stem cell medium. CD44 variant isoforms are known to be more expressed in CSC and metastatic cells than CD44 standard isoform. In agreement, functional analysis of the two sorted and cultured subpopulations has shown that the CD44v8-10pos PC3 cells, resulting from the conversion of the CD44neg subpopulation, were more invasive in vitro and had a higher clonogenic potential than the sorted CD44high cells, in that they produced mainly holoclones, known to be enriched in stem-like cells. Of interest, the CD44v8-10 is more expressed in human PCa biopsies than in normal gland. The discovery of CD44v8-10pos cells with stem-like and invasive features, derived from a minoritarian CD44neg cell population in PCa, alerts on the high plasticity of stem-like markers and urges for prudency on the approaches to targeting the putative CSC

Microrheology with optical tweezers: data analysis

We present a data analysis procedure that provides the solution to a long-standing issue in microrheology studies, i.e. the evaluation of the fluids' linear viscoelastic properties from the analysis of a finite set of experimental data, describing (for instance) the time-dependent mean-square displacement of suspended probe particles experiencing Brownian fluctuations. We report, for the first time in the literature, the linear viscoelastic response of an optically trapped bead suspended in a Newtonian fluid, over the entire range of experimentally accessible frequencies. The general validity of the proposed method makes it transferable to the majority of microrheology and rheology techniques

Merging of globular clusters within inner galactic regions. I. Do they survive the tidal interaction?

The main topic of this paper is the investigation of the modes of interaction of globular clusters (GCs) moving in the inner part of a galaxy. This is tackled by means of high-resolution N-body simulations, whose first results are presented in this article. Our simulations dealt with primordial very massive (order of 10^7 solar masses) GCs that were able to decay, because of dynamical friction, into the inner regions of triaxial galaxies on a time much shorter than their internal relaxation time. To check the disruptive role of both tidal forces and GC-GC collisions, we maximised the tidal interaction considering GCs on quasi-radial orbits. The available CPU resources allowed us to follow 8 oscillations of the GCs along their orbits and the main findings are: i) clusters with an initial high enough King concentration parameter (c>=1.2), preserve up to 50% of their initial mass; ii) the inner density distribution of the survived clusters keep a King model profile; iii) GC-GC collisions have a negligible effect with respect to that caused by the passage through the galactic center; iv) the orbital energy dissipation due to the tidal interaction is of the same order of that caused by dynamical friction; v) complex sub-structures like "ripples" and "clumps" formed, as observed around real clusters. These findings support the validity of the hypothesis of merging of GCs in the galactic central region, with modes that deserve further careful investigations.Comment: LaTeX 2e, AASTeX v5.x, 23 pages with 14 figures. Accepted for publication on the Astrophysical Journal. Final version with major change

Dynamics of the Globular Cluster System Associated with M87 (NGC 4486). II. Analysis

We present a dynamical analysis of the globular cluster system associated with M87 (= NGC 4486), the cD galaxy near the dynamical center of the Virgo cluster. The analysis utilizes a new spectroscopic and photometric database which is described in a companion paper (Hanes et al. 2001). Using a sample of 278 globular clusters with measured radial velocities and metallicities, and new surface density profiles based on wide-field Washington photometry, we study the dynamics of the M87 globular cluster system both globally --- for the entire cluster sample --- and separately --- for the metal-rich and metal-poor globular cluster samples. This constitutes the largest sample of radial velocities for pure Population II tracers yet assembled for any galaxy. We discuss the implications of our findings for models for the formation of giant elliptical galaxies, globular cluster systems, and the Virgo cluster. (ABRIDGED)Comment: 28 pages, 19 postscript figures, 1 jpeg image. See http://www.physics.rutgers.edu/ast/ast-rap.html to download the manuscript with higher quality figures. Accepted for publication in the Astrophysical Journa

Description of Atmospheric Conditions at the Pierre Auger Observatory Using Meteorological Measurements and Models

Atmospheric conditions at the site of a cosmic ray observatory must be known well for reconstructing observed extensive air showers, especially when measured using the fluorescence technique. For the Pierre Auger Observatory, a sophisticated network of atmospheric monitoring devices has been conceived. Part of this monitoring was a weather balloon program to measure atmospheric state variables above the Observatory. To use the data in reconstructions of air showers, monthly models have been constructed. Scheduled balloon launches were abandoned and replaced with launches triggered by high-energetic air showers as part of a rapid monitoring system. Currently, the balloon launch program is halted and atmospheric data from numerical weather prediction models are used. A description of the balloon measurements, the monthly models as well as the data from the numerical weather prediction are presented

The HST Survey of BL Lac Objects: Gravitational Lens Candidates and Other Unusual Sources

We present HST observations of seven unusual objects from the HST ``snapshot survey'' of BL Lac objects, of which four are gravitational lens candidates. In three cases a double point sources is observed: 0033+595, with 1.58 arcsec separation, and 0502+675 and 1440+122, each with $\sim 0.3$ arcsec separation. The last two also show one or more galaxies, which could be either host or lensing galaxies. If any are confirmed as lenses, these BL Lac objects are excellent candidates for measuring H$_0$ via gravitational time delay because of their characteristic rapid, high amplitude variability. An additional advantage is that, like other blazars, they are likely superluminal radio sources, in which case the source plane is mapped out over a period of years, providing strong additional constraints on the lensing mass distribution. The fourth gravitational lens candidate is 1517+656, which is surrounded by three arclets forming an almost perfect ring of radius 2.4 arcsec. If this is indeed an Einstein ring, it is most likely a background source gravitationally lensed by the BL Lac object host galaxy and possibly a surrounding group or cluster. In the extreme case that all four candidates are true lenses, the derived frequency of gravitational lensing in this BL Lac sample would be an order of magnitude higher than in comparable quasar samples. We also report on three other remarkable BL Lac objects: 0138-097, which is surrounded by a large number of close companion galaxies; 0806+524, whose host galaxy contains an uncommon arc-like structure; and 1959+650, which is hosted by a gas rich elliptical galaxy with a prominent dust lane of $\sim 5\times 10^5 M_\odot$.Comment: 29 pages in total, 12 figure