Current status of herbal and their future perspectives

Traditional medicine is the synthesis of therapeutic experience of generations of practicing physicians of indigenous systems of medicine. Throughout the history of mankind, many infectious diseases have been treated with herbals. The traditional medicine is increasingly solicited through the tradipractitioners and herbalists in the treatment of infectious diseases. Among the remedies used, plant drugs constitute an important part. A number of scientific investigations have highlighted the importance and the contribution of many plant families i.e. Asteraceae, Liliaceae, Apocynaceae, Solanaceae, Caesalpinaceae, Rutaceae, Piperaceae, Sapotaceae used as medicinal plants. Medicinal plants play a vital role for the development of new drugs (export and import diverse parts or bioactive compounds in the current market). The bioactive extract should be standardized on the basis of active compound. The bioactive extract should undergo limited safety studies

Preventive measures for cross site request forgery attacks on web-based applications

Today's contemporary business world has incorporated Web Services and Web Applications in its core of operating cycle nowadays and security plays a major role in the amalgamation of such services and applications with the business needs worldwide. OWASP (Open Web Application Security Project) states that the effectiveness of security mechanisms in a Web Application can be estimated by evaluating the degree of vulnerability against any of the nominated top ten vulnerabilities, nominated by the OWASP. This paper sheds light on a number of existing tools that can be used to test for the CSRF vulnerability. The main objective of the research is to identify the available solutions to prevent CSRF attacks. By analyzing the techniques employed in each of the solutions, the optimal tool can be identified. Tests against the exploitation of the vulnerabilities were conducted after implementing the solutions into the web application to check the efficacy of each of the solutions. The research also proposes a combined solution that integrates the passing of an unpredictable token through a hidden field and validating it on the server side with the passing of token through URL

Comprehensive literature review on delay tolerant network (DTN) framework for improving the efficiency of internet connection in rural regions of Malaysia

This paper brief in detail the technology reviews of current available technologies and literature reviews that starts with the history of the Internet and the understanding of the working of the Internet through a conceptual model of TCP/IP and OSI models, the numerous technologies developed to cater for different connectivity environments and recent popular topics in the field of communication technologies. Detailed review is done on the subject of Delay-Tolerant Networking (DTN), the chosen technology from which the intended framework can be proposed for improving the efficiency of internet connections. From these literatures, comparisons are made to find the best possible combinations of technologies to design a mini- mum viable product, followed by a generic DTN framework

Proposed data quality evaluation method for a transportation agency

The data quality evaluation is essential towards designing a data assessment method for any company because data is an important asset. Therefore, the purpose of this study is to develop the data quality evaluation method for a transportation agency in Malaysia in order to quantify the quality of data in the SIKAP licensing system. This can benefit the transportation agency to improve the quality of data for the use of reporting, forecasting business operations and data integration with other agency’s systems. The relevant data evaluation dimensions have been identified from literature study and relative data evaluation framework which are necessarily required by the transportation agency to maintain high data quality in the SIKAP system. The process design for the proposed method involves data dimension identification, capturing the relevant database structure, subjective evaluation with a questionnaire and objective evaluation with data profiling. From the design process, the result shows that data evaluation method for a transportation agency must have a minimum of six data quality dimensions. SIKAP, the legacy system is in the process to revamp into a new system. Thus, this research contributes to enhance the current system’s data quality during revamping process and data migration into the new system

Proceedings of the 2nd International Workshop on Digital Language Archives: LangArc 2023

Article presenting an overview of the Bharatavani project, which focuses on recording socio-cultural and linguistic information about 121 Indian languages and making it accessible to a broader audience. It was presented at the 2nd International Workshop on Digital Language Archives held on June 30, 2023 as part of the ACM/IEEE Joint Conference on Digital Libraries 2023

Antimicrobial, Antioxidant and Cytotoxic Activities and Phytochemical Screening of Some Yemeni Medicinal Plants

The traditional medicine still plays an important role in the primary health care in Yemen. The current study represents the investigation of 16 selected plants, which were collected from different localities of Yemen. The plants were dried and extracted with two different solvents (methanol and hot water) to yield 34 crude extracts. The obtained extracts were tested for their antimicrobial activity against three Gram-positive bacteria, two Gram-negative bacteria, one yeast species and three multiresistant Staphylococcus strains using agar diffusion method, for their antioxidant activity using scavenging activity of DPPH radical method and for their cytotoxic activity using the neutral red uptake assay. In addition, a phytochemical screening of the methanolic extracts was done. Antibacterial activity was shown only against Gram-positive bacteria, among them multiresistant bacteria. The highest antimicrobial activity was exhibited by the methanolic extracts of Acalypha fruticosa, Centaurea pseudosinaica, Dodonaea viscosa, Jatropha variegata, Lippia citriodora, Plectranthus hadiensis, Tragia pungens and Verbascum bottae. Six methanolic extracts especially those of A. fruticosa, Actiniopteris semiflabellata, D. viscosa, P. hadiensis, T. pungens and V. bottae showed high free radical scavenging activity. Moreover, remarkable cytotoxic activity against FL-cells was found for the methanolic extracts of A. fruticosa, Iris albicans, L. citriodora and T. pungens. The phytochemical screening demonstrated the presence of different types of compounds like flavonoids, terpenoids and others, which could be responsible for the obtained activities

Annexins in Influenza Virus Replication and Pathogenesis

Influenza A viruses (IAVs) are important human respiratory pathogens which cause seasonal or periodic endemic infections. IAV can result in severe or fatal clinical complications including pneumonia and respiratory distress syndrome. Treatment of IAV infections is complicated because the virus can evade host immunity through antigenic drifts and antigenic shifts, to establish infections making new treatment options desirable. Annexins (ANXs) are a family of calcium and phospholipid binding proteins with immunomodulatory roles in viral infections, lung injury, and inflammation. A current understanding of the role of ANXs in modulating IAV infection and host responses will enable the future development of more effective antiviral therapies. This review presents a comprehensive understanding of the advances made in the field of ANXs, in particular, ANXA1 and IAV research and highlights the importance of ANXs as a suitable target for IAV therapy

Identification of a Novel Calotropis procera Protein That Can Suppress Tumor Growth in Breast Cancer through the Suppression of NF-κB Pathway

10.1371/journal.pone.0048514PLoS ONE712

Emodin Suppresses Migration and Invasion through the Modulation of CXCR4 Expression in an Orthotopic Model of Human Hepatocellular Carcinoma

10.1371/journal.pone.0057015PLoS ONE83