Frontiers of Adaptive Design, Synthetic Biology and Growing Skins for Ephemeral Hybrid Structures

The history of membranes is one of adaptation, from the development in living organisms to man-made versions, with a great variety of uses in temporary design: clothing, building, packaging, etc. Being versatile and simple to integrate, membranes have a strong sustainability potential, through an essential use of material resources and multifunctional design, representing one of the purest cases where “design follows function.” The introduction of new engineered materials and techniques, combined with a growing interest for Nature-inspired technologies are progressively merging man-made artifacts and biological processes with a high potential for innovation. This chapter introduces, through a number of examples, the broad variety of hybrid membranes in the contest of experimental Design, Art and Architecture, categorized following two different stages of biology-inspired approach with the aim of identifying potential developments. Biomimicry, is founded on the adoption of practices from nature in architecture though imitation: solutions are observed on a morphological, structural or procedural level and copied to design everything from nanoscale materials to building technologies. Synthetic biology relies on hybrid procedures mixing natural and synthetic materials and processes

On the History and Prospects of Three-Dimensional Human-Computer Interfaces for the provision of Air Traffic Control Services

This paper is an essay on the history and prospects of three-dimensional (3D) human- computer interfaces for the provision of air traffic control services. Over the past twenty-five years, many empirical studies have addressed this topic. However, the results have been deemed incoherent and self-contradictory and no common conclusion has been reached. To escape from the deadlock of the experimental approach, this study takes a step back into the conceptual development of 3D interfaces, addressing the fundamental benefits and drawbacks of 3D rendering. Under this light, many results in the literature start to make sense and some conclusions can be drawn. Also, with an emphasis on the future of air traffic control, this research identifies a set of tasks wherein the intrinsic weaknesses of 3D rendering can be minimized and its advantages can be exploited. These are the ones that do not require accurate estimates of distances or angles. For future developments in the field of 3D interfaces for air traffic control operators, we suggest focusing on those tasks only

Gli indirizzi giurisprudenziali della Corte di giustizia in materia di asilo

Il presente elaborato ha l’obiettivo di analizzare e studiare le ricadute della giurisprudenza della Corte di giustizia sulla legislazione europea concernente l’asilo, dal momento che l’Unione europea, dal 1999, si è impegnata ad addivenire progressivamente ad un CEAS. Si deve subito ricordare che la piena competenza della Corte di giustizia a pronunciarsi, attraverso lo strumento del rinvio pregiudiziale, su tale materia è avvenuta solo con il Trattato di Lisbona. Un tale studio mira inoltre a far emergere i parametri giuridici che la stessa Corte utilizza per interpretare i regolamenti e le direttive concernenti l’asilo, cioè come tale organo giurisdizionale interpreta il diritto derivato in tela materia alla luce del diritto primario. Una volta chiarita l’importanza di una siffatta competenza pregiudiziale di tale organo e una volta specificato il ruolo dei parametri giuridici che la stessa utilizza per interpretare il diritto derivato riguardante la materia dell’asilo, tale lavoro procede all’analisi delle sentenze fin’ora pronunciate dalla Corte di giustizia suddivise per argomenti. Nel terzo capitolo verrà affrontata l’analisi della giurisprudenza della Corte relativa al c.d. regolamento Dublino II, il quale mira a stabilire i criteri e i meccanismi per la determinazione dello Stato membro competente all’esame di una domanda di asilo, verranno messi in risalto i ragionamenti giuridici della Corte e la capacità della stessa di imprimere un’interpretazione modificatrice dello stesso regolamento. Nel successivo capitolo verrà analizzata la giurisprudenza relativa alla direttiva qualifiche, la 2004/83, concernete i requisiti per la concessione, esclusione e cessazione sia dello status di rifugiato che della protezione sussidiaria. Infine, nell’ultimo capitolo verrà analizzata la giurisprudenza relativa alla direttiva accoglienza, la 2003/09, concernete le condizioni minime di accoglienza da garantire ai richiedenti asilo, oltre all’analisi di due sentenze concernenti la direttiva procedure, la 2005/85, relativa alle norme minime per le procedure applicate negli Stati membri ai fini del riconoscimento e della revoca dello status di rifugiato. Al termine dell’analisi delle sentenze verrà anche sottolineato quanta e quale giurisprudenza è stata recepita dal legislatore europeo e dove invece la Corte continua a svolgere il ruolo di “supplente”. Si deve inoltre evidenziare che si tratta di una giurisprudenza ancora agli albori e del tutto in evoluzione e solo monitorando la situazione negli anni successivi si potranno trarre delle parziali conclusioni

Isolated olecranon fractures in children affected by osteogenesis imperfecta type I treated with single screw or tension band wiring system: outcomes and pitfalls in relation to bone mineral density

The purpose of this study is to compare the results of 2 techniques, tension band wiring (TBW) and fixation with screws, in olecranon fractures in children affected with osteogenesis imperfecta (OI) type I. Between 2010 and 2014, 21 olecranon fractures in 18 children with OI (average age: 12 years old) were treated surgically. Ten patients were treated with the screw fixation and 11 with TBW. A total of 65% of olecranon fractures occurred as a result of a spontaneous avulsion of the olecranon during the contraction of the triceps muscle. The average follow-up was 36 months. Among the children treated with 1 screw, 5 patients needed a surgical revision with TBW due to a mobilization of the screw. In this group, the satisfactory results were 50%. In patients treated with TBW, the satisfactory results were 100% of the cases. The average Z-score, the last one recorded in the patients before the trauma, was -2.53 in patients treated with screw fixation and -2.04 in those treated with TBW. TBW represents the safest surgical treatment for patients suffering from OI type I, as it helps to prevent the rigidity of the elbow through an earlier recovery of the range of motion, and there was no loosening of the implant. In analyzing the average Z-score before any fracture, the fixation with screws has an increased risk of failure in combination with low bone mineral density

Saprotrophic soil fungi to improve phosphorus solubilisation and release. In vitro abilities of several species

Modern agriculture is dependent on phosphate rock (PR), which is a nonrenewable resource. Improvement of phosphorus (P) availability for crops in agricultural soils represents a key strategy to slow down the depletion of PR. The aim of this study was to identify potential P biofertilisers among saprotrophic fungal species. We tested 30 fungal strains belonging to 28 taxa (4 Zygomycota and 24 Ascomycota) and with different life strategies. The study showed that many saprotrophic fungi have the ability to mobilise P from insoluble forms according to a variety of mechanisms. Our results expand the pool of P solubilising fungal species, also suggesting a new solubilisation index and shedding light on parameters that could be basic in the selection of efficient soil P-biofertilisers fungi. Rhizopus stolonifer var. stolonifer, Aspergillus niger and Alternaria alternata were found to be the best performing strains in terms of amounts of TCP solubilisation

Fluoroscopic freehand and electromagnetic-guided targeting system for distal locking screws of humeral intramedullary nail

Purpose The current techniques used to lock distal screws for the nailing of long bone fractures expose the surgeons, radiologists and patients to a hearty dose of ionizing radiation. The Sureshot™ Distal Targeting System is a new technique that, with the same results, allows for shorter surgery times and, consequently, less exposure to radiation. Materials and methods The study was performed on 59 patients (34 males and 25 females) with a simple humerus fracture diagnosis, type 1.2.A according to the AO classification, who were divided into two groups. Group 1 was treated with ante-grade intramedullary nailing with distal locking screws inserted with a freehand technique. Group 2 was treated with the intramedullary nail using the Sureshot™ Distal Targeting System. Two intra-operative time parameters were evaluated in both groups: the time needed for the positioning of the distal locking screws and the time of exposure to ionizing radiations during this procedure. Results Group 2 showed a lower average distal locking time compared to group 1 (645.48″ vs. 1023.57″) and also a lower average time of exposure to ionizing radiation than in group 1 (4.35″ vs. 28.96″). Conclusion The Sureshot™ Distal Targeting System has proven to be equally effective when compared to the traditional techniques, with the added benefits of a significant reduction in both surgical time and risk factors related to the exposure to ionizing radiation for all the operating room staff and the patient

Association between spondylolisthesis and L5 fracture in patients with osteogenesis imperfecta

To investigate if an association between spondylolisthesis and L5 fracture occurs in patients affected by Osteogenesis Imperfecta (O.I.). Methods Anteroposterior and lateral radiograms were performed on the sample (38 O.I. patients, of whom 19 presenting listhesis); on imaging studies spondylolisthesis was quantified according to the Meyerding classification. Genant’s semiquantitative classification was applied on lateral view to evaluate the L5 fractures; skeleton spinal morphometry (MXA) was carried out on the same images to collect quantitative data comparable and superimposable to Genant’s classification. The gathered information were analyzed through statistical tests (O.R., χ 2 test, Fisher’s test, Pearson’s correlation coefficient). Results The prevalence of L5 fractures is 73.7 % in O.I. patients with spondylolisthesis and their risk of experiencing such a fracture is twice than O.I. patients without listhesis (OR 2.04). Pearson’s χ 2 test demonstrates an association between L5 spondylolisthesis and L5 fracture, especially with moderate, posterior fractures (p = 0.017) and primarily in patients affected by type IV O.I. Conclusions Spondylolisthesis represents a risk factor for the development of more severe and biconcave/posterior type fractures of L5 in patients suffering from O.I., especially in type IV. This fits the hypothesis that the anterior sliding of the soma of L5 alters the dynamics of action of the load forces, localizing them on the central and posterior heights that become the focus of the stress due to movement of flexion–extension and twisting of the spine. As a result, there is greater probability of developing an important subsidence of the central and posterior walls of the soma

Clinical and biochemical response to neridronate treatment in a patient with osteoporosis-pseudoglioma syndrome (OPPG)

Osteoporosis-pseudoglioma syndrome (OPPG) is a rare autosomal recessive syndrome characterized by juvenile-onset osteoporosis and ocular abnormalities due to a low-density lipoprotein receptor-related protein 5 (LRP5) gene mutation. Treatment with bisphosphonates, particularly with pamidronate and risedronate, has been reported to be of some efficacy in this condition. We report on a patient with OPPG due to an LRP5 gene mutation, who showed an encouraging response after a 36-month period of neridronate therapy. We report a case of a patient treated with bisphosphonates. Bisphosphonates should be administered in OPPG patients as a first-line therapy during early childhood

Serum creatine kinase isoenzymes in children with osteogenesis imperfecta

This study evaluates serum creatine kinase isoenzyme activity in children with osteogenesis imperfecta to determine its usefulness as a biochemical marker during treatment with bisphosphonate. The changes of creatine kinase (CK) isoenzyme activity during and after discontinuation therapy were observed. These results could be useful in addressing over-treatment risk prevention. Introduction The brain isoenzyme of creatine kinase (CKbb) is highly expressed in mature osteoclasts during osteoclastogenesis, thus plays an important role in bone resorption. We previously identified high serum CKbb levels in 18 children with osteogenesis imperfect (OI) type 1 treated for 1 year with bisphosphonate (neridronate). In the present study, serum CK isoenzymes were evaluated in the same children with continuous versus discontinued neridronate treatment over a further 2-year follow-up period. Methods This study included 18 children with OI type 1, 12 with continued (group A) and 6 with ceased (group B) neridronate treatment. Auxological data, serum biochemical markers of bone metabolism, bone mineral density z-score, and serum total CK and isoenzyme activities were determined in both groups. Results Serum CKbb was progressively and significantly increased in group A (p < 0.004) but rapidly decreased to undetectable levels in group B. In both groups, the cardiac muscle creatine kinase isoenzyme (CKmb) showed a marked decrease, while serum C-terminal telopeptide (CTx) levels were almost unchanged. Conclusions This study provides evidence of the cumulative effect of neridronate administration in increasing serum CKbb levels and the reversible effect after its discontinuation. This approach could be employed for verifying the usefulness of serum CKbb as a biochemical marker in patients receiving prolonged bisphosphonate treatment. Moreover, the decreased serum CKmb levels suggest a systemic effect of these drugs

Choice of three different intramedullary nails in the treatment of trochanteric fractures: outcome, analysis and consideration in midterm

paragone di 3 differenti impianti per frattura pertrocanterica femoreThe purpose of this study is to compare the results obtained using three different systems of osteosynthesis, developed for the surgical treatment of fractures of the trochanteric region of the femur, based on the principle intramedullary nailing: the Gamma nail, the Affixus nail and the ZNN nail. This is a retrospective study: 72 trochanteric fractures treated with the Gamma nail, 68 treated with the Affixus nail and 69 treated with the ZNN nail, between the years 2012 and 2014, with the prerequisite of a minimum follow-up of 18 months. The fractures were classified according to the AO system; the most commonly reported subtype was the A2 fracture. Clinical and radiographic examinations were performed, both at hospital admission and post-operatively, at 1, 3, 6, 12 and 18 months. Of the 209 patients, 171 were women and 38 were men. The average age was 83.12 years old. All three systems guaranteed an early mobilization and ambulation in most of the patients. There were no significant differences in the use of the three nails in terms of recovery of previous functional capacity, or in terms of the time required for the fracture to heal. There were no advantages encountered with the use of one intramedullary nail over another and, in particular, when observing the complications and patient outcome, there were no statistically significant differences detected