Non-Organic Motor Disorder: Combatting the Effects of Stress on Functional Mobility

The purpose of the case report was to show how neurological symptoms can be effectively treated with task-specific interventions and the role of stress in symptom presentation in patients with somatoform disorders.https://soar.usa.edu/flsaspring2018/1013/thumbnail.jp

Don’t Let Me Fall: Implementing the Use of Assistive Standing Device with Functional Task Specific Training Can Improve Safety of Transfers in a 65 Y/O Woman with Primary Lateral Sclerosis: A Case Report

The purpose of this case report is to describe improvements of a novel functional training program in a patient diagnosed with PLS.https://soar.usa.edu/flsaspring2017/1016/thumbnail.jp

Ehlers-Danlos Syndrome-Hypermobility Type: Can We Use Physical Therapy Manipulation?

The purpose of this case is to describe the clinical treatment plan for a patient diagnosed with Ehlers-Danlos Syndrome hypermobility type and determine the benefits of low grade physical therapy manipulation as an intervention.https://soar.usa.edu/flsasummer2018/1004/thumbnail.jp

An Orthopedic Solution to a Neurological Problem -Core Stabilization Post Stroke: A Case Report

The purpose of this case report is to report the outcomes of combining manual therapy techniques for spinal mobility and stability with traditional neurological approaches to stroke rehabilitation.https://soar.usa.edu/flsaspring2018/1012/thumbnail.jp

The relationship between adiposity, bone density and microarchitecture is maintained in young women irrespective of diabetes status

Background: The relationship between bone health and adiposity and how it may be affected in people with chronic metabolic conditions is complex. Methods: 17 women with Type 1 diabetes mellitus (T1DM) and 9 age-matched healthy women with a median age of 22.6 yrs (range, 17.4, 23.8) were studied by 3T-MRI and MR spectroscopy to assess abdominal adiposity, tibial bone microarchitecture and vertebral bone marrow adiposity. Additional measures included DXA-based assessments of total body (TB), femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) and fat mass (FM). Results: Although women with T1DM had similar BMI and bone marrow adiposity to the controls, they had higher visceral and subcutaneous adiposity on MRI (p<0.05) and total body FM by DXA (p=0.03). Overall, in the whole cohort, a clear inverse association was evident between bone marrow adiposity and BMD at all sites (p<0.05). These associations remained significant after adjusting for age, BMI, FM, and abdominal adiposity. In addition, visceral adiposity, but not subcutaneous adiposity, showed a positive association with bone marrow adiposity (r,0.4, p=0.03), and a negative association with total body BMD (r,0.5, p=0.02). Apparent trabecular separation as assessed by MRI showed an inverse association to total body BMD by DXA (r,–0.4, p=0.04). Conclusion: Irrespective of the presence of an underlying metabolic condition, young women display a negative relationship between MRI-measured bone marrow adiposity and DXA-based assessment of bone mineral density. Furthermore, an association between bone marrow adiposity and visceral adiposity supports the notion of a common origin of these two fat depots

The role of online knowledge hubs in developing practice and policy: Lessons from i-HOP for professionals working with children and families affected by parental offending

This paper reports on the role of an online knowledge hub in supporting the development of policy and practice relevant to children and families affected by parental offending. The authors use a case study of the i-HOP service, a national web-based collection of resources that supports professionals to work with children and families affected by parental offending. Delivered by the national children’s charity Barnardo’s, the knowledge hub provides a comprehensive collection of research and evidence, policy frameworks, practice examples, funding opportunities and training resources (https://www.i-hop.org.uk). The paper begins by considering the rationale behind the development hub, including an increase in the number of children and families affected by parental offending, unsystematic policy response and limited resources for practitioners working with children and families. Next, the paper discusses the development of the hub, including the challenges encountered and practical solutions employed. The implementation of a quality assessment system to support policy-makers and practitioners to make informed judgements about the suitability and quality of research and evidence deposited on the hub is also considered. The paper concludes with practical suggestions for organisations that are contemplating the development of a knowledge hub to bridge the gap between research and evidence and practice and policy

The role of the gut microbiome in sustainable teleost aquaculture

As the most diverse vertebrate group and a major component of a growing global aquaculture industry, teleosts continue to attract significant scientific attention. The growth in global aquaculture, driven by declines in wild stocks, has provided additional empirical demand, and thus opportunities, to explore teleost diversity. Among key developments is the recent growth in microbiome exploration, facilitated by advances in high-throughput sequencing technologies. Here, we consider studies on teleost gut microbiomes in the context of sustainable aquaculture, which we have discussed in four themes: diet, immunity, artificial selection and closed-loop systems. We demonstrate the influence aquaculture has had on gut microbiome research, while also providing a road map for the main deterministic forces that influence the gut microbiome, with topical applications to aquaculture. Functional significance is considered within an aquaculture context with reference to impacts on nutrition and immunity. Finally, we identify key knowledge gaps, both methodological and conceptual, and propose promising applications of gut microbiome manipulation to aquaculture, and future priorities in microbiome research. These include insect-based feeds, vaccination, mechanism of pro- and prebiotics, artificial selection on the hologenome, in-water bacteriophages in recirculating aquaculture systems (RAS), physiochemical properties of water and dysbiosis as a biomarker

microRNA expression in the aging mouse lung

BACKGROUND: MicroRNAs (miRNAs) are a novel class of short double stranded RNA that mediate the post-transcriptional regulation of gene expression. Previous studies have implicated changes in miRNA expression in the regulation of development and the induction of diseases such as cancer. However, although miRNAs have been implicated in the process of aging in C. elegans, nothing is known of their role in mammalian tissues. RESULTS: To address this question, we have used a highly-sensitive, semi-quantitative RT-PCR based approach to measure the expression profile of 256 of the 493 currently identified miRNAs in the lungs from 6 month (adult) and 18 month (aged) old female BALB/c mice. We show that, despite the characteristic changes in anatomy and gene expression associated with lung aging, there were no significant changes in the expression of 256 miRNAs. CONCLUSION: Overall, these results show that miRNA transcription is unchanged during lung aging and suggests that stable expression of miRNAs might instead buffer age related changes in the expression of protein-encoding gene

Novel Patterns of Torsion-Inversion-Rotation Energy Levels in the ν11 Asymmetric CH-Stretch Spectrum of Methylamine

The high-resolution infrared spectrum of methylamine (CH3NH2) has been recorded using slit-jet direct absorption spectroscopy in the ν11 CH-stretch region (2965–3005 cm−1) with a resolution of 0.0025 cm−1. The 621 lines assigned by ground state combination differences represent 27 substates with |K′| ≤ 2 for the A, B, E1, and E2 symmetries. The spectrum of CH3NH2 is complicated by torsion and inversion tunneling connecting six equivalent minima. The upper states K′ = 0, ± 1 for E1 and E2 are substantially perturbed by “dark” states. The result in the spectrum is multiplets of 2 or 3 states with mixed bright/dark character. The analysis of the spectrum reveals two qualitative differences in the energy level pattern relative to the vibrational ground state and relative to available data on the lower frequency vibrations (NH2 wag and CN stretch). First at J′ = 0, there is a different ordering of the levels connected by torsion-inversion tunneling. Second, the low-J splittings indicative of torsion-rotation coupling are greatly reduced in the ν11 excited state relative to the vibrational ground state for both the E1 and E2 species, suggesting the partial suppression of torsional tunneling in the ν11 CH-stretch excited state

The safety and efficacy of laparoscopic retrograde appendicectomy, base-to-tip approach

BackgroundLaparoscopic appendicectomy is one of the most frequently performed surgical procedures worldwide. There is limited evidence evaluating the role and safety of laparoscopic retrograde appendicectomy (LRA), base to tip approach, compared to standard laparoscopic antegrade appendicectomy (LAA), tip to base approach. This study aims to assess the safety of LRA compared to LAA in terms of intra-abdominal collection (IAC) rate and using Sunshine Appendicitis Grading System (SAGS).MethodsRecords of two-hundred and seventy-three patients undergoing laparoscopic appendicectomy by LAA and LRA approaches were analysed. The severity of appendicitis was rated using a standardised Sunshine Appendicitis Grading System (SAGS) score intra-operatively. The primary outcome measure was the occurrence of an intra-abdominal collection, and secondary measures were procedure time, post-operative length of stay and other complications.ResultsOf the two-hundred and seventy-three patients, there were two patients who developed an intra-abdominal collection. Both patients were in the LAA group with SAGS IV scores. Between SAGS IV patients, Chi-squared p value of 0.6691. Therefore, there was no statically significant difference in the intra-abdominal collection (IAC) rate between LAA and LRA groups from this study.ConclusionsThe current study has shown that laparoscopic retrograde appendicectomy (LRA) does not increase risk of intra-abdominal collection compared to laparoscopic antegrade appendicectomy (LAA) within the limit of this study