Spanish-English Bilingual Toddlers’ Vocabulary Skills: The role of Caregiver Language Input and Warmth

There is a well-documented link between bilingual language development and the relative amounts of exposure to each language. Less is known about the role of quality indicators of caregiver-child interactions in bilingual homes, including caregiver input diversity, warmth and sensitivity. This longitudinal study examines the relation between caregiver input (lexical diversity, amount), warmth and sensitivity and bilingual toddlers’ subsequent vocabulary outcomes. We video-recorded caregiver-child interactions in Spanish-English Latino homes when toddlers (n = 47) were 18 months of age (M = 18.32 months; SD = 1.02 months). At the 24-month follow-up, we measured children\u27s vocabulary as total vocabulary (English, Spanish combined) as well as within language (Spanish, English). Results revealed that Spanish lexical diversity exposure at 18 months from caregivers was positively associated with children\u27s Spanish and total vocabulary scores at 24 months, while English lexical diversity was positively associated with children\u27s English scores; lexical diversity and amount were highly correlated. Additionally, caregivers’ warmth was positively associated with children\u27s Spanish, English and total vocabulary scores. Together, these factors accounted for substantial variance (30–40%) in vocabulary outcomes. Notably, caregiver input accounted for more variance in single language outcomes than did caregiver warmth, whereas caregiver warmth uniquely accounted for more variance in total vocabulary scores. Our findings extend prior research findings by suggesting that children\u27s dual language development may depend on their exposure to a diverse set of words, not only amount of language exposure, as well as warm interactions with caregivers. A video abstract of this article can be viewed at https://youtu.be/q1V_7fz5wogHighlightsVideo-recorded observations of caregiver-child interactions revealed warmth and high sensitivity from Latino caregivers.Linguistically-detailed analyses of caregiver input revealed wide variation in the diversity of Spanish and English directed at 18-month-old bilingual toddlers.Bilingual toddlers’ vocabulary (single language, total) was positively associated with caregivers’ diverse input and warmth, thus extending prior findings on bilinguals’ amount of language exposure.Findings suggest that caregivers’ lexical diversity explains more variance in bilingual toddlers’ single language outcomes, whereas warmth explains more variance in total vocabulary scores

Reflecting on professional development

This paper describes how a cluster of ten secondary science teachers from six different schools and colleges in the UK designed and undertook small-scale action research projects as an approach to their own Continuing Professional Development (CPD). The participating teachers identified a range of topics for investigation such as student voice, engagement and motivation in STEM (Science Technology Engineering Mathematics) learning and effective practical work. They brought their research into practice either as individuals, pairs or within a team. Central to each project was the use of reflection as a primary tool for ensuring the impact of the professional development and for stimulating a teacher-led process. Reflective practice was developed through the use of three approaches; audio sound bites, reflective blogs, and reflective discussions. The teachers used reflection as a means of self-evaluation as well as evaluation of their action research interventions. The reflective practice which the teachers engaged in enabled them to think carefully about what was taking place in a given situation during their designed interventions, to identify suitable options, and to make conscious choices about what to do in order to make a difference. The participating teachers all concluded that reflective methods that enable self-reflection as well as reflection upon designed classroom interventions are hugely beneficial to effective CPD for teachers

Light-Front Quantisation as an Initial-Boundary Value Problem

In the light front quantisation scheme initial conditions are usually provided on a single lightlike hyperplane. This, however, is insufficient to yield a unique solution of the field equations. We investigate under which additional conditions the problem of solving the field equations becomes well posed. The consequences for quantisation are studied within a Hamiltonian formulation by using the method of Faddeev and Jackiw for dealing with first-order Lagrangians. For the prototype field theory of massive scalar fields in 1+1 dimensions, we find that initial conditions for fixed light cone time {\sl and} boundary conditions in the spatial variable are sufficient to yield a consistent commutator algebra. Data on a second lightlike hyperplane are not necessary. Hamiltonian and Euler-Lagrange equations of motion become equivalent; the description of the dynamics remains canonical and simple. In this way we justify the approach of discretised light cone quantisation.Comment: 26 pages (including figure), tex, figure in latex, TPR 93-

A preliminary study of the effect of closed incision management with negative pressure wound therapy over high-risk incisions

Background Certain postoperative wounds are recognised to be associated with more complications than others and may be termed high-risk. Wound healing can be particularly challenging following high-energy trauma where wound necrosis and infection rates are high. Surgical incision for joint arthrodesis can also be considered high-risk as it requires extensive and invasive surgery and postoperative distal limb swelling and wound dehiscence are common. Recent human literature has investigated the use of negative pressure wound therapy (NPWT) over high-risk closed surgical incisions and beneficial effects have been noted including decreased drainage, decreased dehiscence and decreased infection rates. In a randomised, controlled study twenty cases undergoing distal limb high-energy fracture stabilisation or arthrodesis were randomised to NPWT or control groups. All cases had a modified Robert-Jones dressing applied for 72 h postoperatively and NPWT was applied for 24 h in the NPWT group. Morphometric assessment of limb circumference was performed at six sites preoperatively, 24 and 72 h postoperatively. Wound discharge was assessed at 24 and 72 h. Postoperative analgesia protocol was standardised and a Glasgow Composite Measure Pain Score (GCPS) carried out at 24, 48 and 72 h. Complications were noted and differences between groups were assessed. Results Percentage change in limb circumference between preoperative and 24 and 72 h postoperative measurements was significantly less at all sites for the NPWT group with exception of the joint proximal to the surgical site and the centre of the operated bone at 72 h. Median discharge score was lower in the NPWT group than the control group at 24 h. No significant differences in GCPS or complication rates were noted. Conclusions Digital swelling and wound discharge were reduced when NPWT was employed for closed incision management. Larger studies are required to evaluate whether this will result in reduced discomfort and complication rates postoperatively

Tamoxifen Is Effective in the Treatment of Leishmania amazonensis Infections in Mice

Leishmaniasis is an antropozoonotic disease with a wide range of clinical manifestations. In humans, signs of disease vary from skin and mucosal ulcers to enlargement of internal organs such as the liver and spleen. The unicellular parasite Leishmania amazonensis is able to infect humans and cause localized or diffuse skin lesions. The treatment for this disease is difficult, as it requires prolonged and painful applications of toxic drugs that are poorly tolerated. Therefore, a key area in leishmaniasis research is the study of new therapeutic schemes and less toxic drugs. The present report is based on the investigation of tamoxifen's activity (a compound that has been in clinical use since the 1970s for the treatment of breast cancer) in the treatment of mice experimentally infected with L. amazonensis. We observed that infected mice treated with 20 mg/kg/day of tamoxifen for 15 days showed a significant clinical and parasitological response, with reduction in the size of lesions and ulcers and decreased numbers of parasites. These promising results pave the way for further testing of this drug as a new alternative in the chemotherapy of leishmaniasis

The social construction of violence among Northern Plains tribal members with antisocial personality disorder and alcohol use disorder

Whereas recent reports from national studies have presented extremely high rates for many personality disorders in American Indian communities, persistent concerns about the meaning of these symptoms have left many troubled by these reports. American Indians as a group are known to suffer disproportionately from a number of violent experiences, but the dynamics of this violence have received little attention. This paper examines perspectives on violence in the lives of 15 northern plains tribal members who met criteria for antisocial personality disorder and comorbid alcohol use disorder. It explores how study participants constructed and understood their own violent encounters, as well as the motivations they described (characterized here as reputation, leveling, retaliation, catharsis, and self-defense). Violence was gendered in this study, with men generally presenting as perpetrators and women as victims. Men often described themselves as ready participants in a violent world, while women were quite clear that aggression for them was often simply required as they tried to defend themselves from male violence. While this analysis does not replace clinical analyses of violence in antisocial personality disorder, it does reveal an underlying cultural logic that may play a role in shaping the recourse to violence for that minority of individuals for whom it appears to be the obvious choice.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Characterization of Coding Synonymous and Non-Synonymous Variants in ADAMTS13 Using Ex Vivo and In Silico Approaches

Synonymous variations, which are defined as codon substitutions that do not change the encoded amino acid, were previously thought to have no effect on the properties of the synthesized protein(s). However, mounting evidence shows that these “silent” variations can have a significant impact on protein expression and function and should no longer be considered “silent”. Here, the effects of six synonymous and six non-synonymous variations, previously found in the gene of ADAMTS13, the von Willebrand Factor (VWF) cleaving hemostatic protease, have been investigated using a variety of approaches. The ADAMTS13 mRNA and protein expression levels, as well as the conformation and activity of the variants have been compared to that of wild-type ADAMTS13. Interestingly, not only the non-synonymous variants but also the synonymous variants have been found to change the protein expression levels, conformation and function. Bioinformatic analysis of ADAMTS13 mRNA structure, amino acid conservation and codon usage allowed us to establish correlations between mRNA stability, RSCU, and intracellular protein expression. This study demonstrates that variants and more specifically, synonymous variants can have a substantial and definite effect on ADAMTS13 function and that bioinformatic analysis may allow development of predictive tools to identify variants that will have significant effects on the encoded protein