692 research outputs found

    The Economic Impacts of School Closure in Rural Maine

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    The purpose of this case study research was to examine the economic impact of school closures on three rural communities in Maine. I created a conceptual framework around six healthy community economic markers. Each of the six markers are studied in 2010 when schools were closed and then again in 2016. This data, in addition to perceptions data from stakeholders in each of the three communities was studied to determine if the closure of the school had any impact on these healthy economic markers. Findings suggest that there were no negative impact to the economic markers studied within the three sample communities that could be attributed solely to the closure of the school. The research did uncover that even though schools were closed to save money and reduce taxes, the fact of the matter is that in two of the three communities studied this cost savings never occurred, nor did a reduction in taxes. Further research is needed to build off this study in order to better inform state and local policy makers who are having to consider whether or not to close schools now and in the future

    Sources and pathways of bacterial contamination of groundwater resources within a rural Montana subdivision

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    Opioid-sensitized patients and acute pain in the ED: A Systematic Review

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    Modeling Land and Hold Short Operations: Balancing Safety and Arrival Rate

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    Many airports conduct simultaneous operations on intersecting runways to increase the rate of takeoffs and landings. This requires landing aircraft to hold short of the intersecting runway, which incurs a safety risk of runway incursions in the process. A Monte Carlo simulation was conducted to analyze the traffic load at maximum operational capacity at Charlotte-Douglas International Airport in order to analyze the fleet types and the rate of those landing aircraft unable to stop short of the intersecting runway. The researchers used the actual and four alternative compositions of the subject airline’s aircraft arrivals, interspersed among other airport traffic, to assess how such changes affect the rate of runway incursions, the rate of operations at the airport, and the mean number of passengers the subject airline can land per hour. The simulation revealed that runway length up to the hold short point was the biggest determinant of aircraft being unable to hold short. The total airport rate of operations decreased when heavy wake turbulence category aircraft were introduced. Despite heavy wake turbulence category aircraft carrying more passengers individually, the decreased operations rate also led to fewer passengers per hour that the subject airline could carry

    Evaluation of caffeine and taurine administration in improving neurodegenerative dysfunction in Caenorhabditis elegans overexpressing the APP ortholog: APL-1

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    INTRODUCTION: Alzheimer’s Disease (AD) is characterized by an over-accumulation of β-amyloid plaques and neurofibrillary Tau tangles present within the brain, contributing to associative neurodegeneration. Taurine is an essential amino acid found within the nervous system; however, it is one of a few amino acids not required in routine protein synthesis. Caffeine and taurine have both been identified as active ingredients in energy drinks with the benefit of improving nervous system function, supporting neural recovery, and synaptogenesis. In previous studies, taurine has been shown to increase memory retention in animal models, and consumption of caffeine reflects improvement in locomotion, memory, and lifespan. OBJECTIVES: This project aims to determine the impact of caffeine and taurine on a mutant C. elegans strain, ynIs-79, which over-expresses the amyloid precursor protein ortholog, APL-1 within its nervous system. We expect that supplementing the mutant ynIs-79 nematode’s diet with caffeine and/or taurine will positively influence the observed neurodegenerative dysfunction by reducing the number of taps required to induce habituation. We hypothesize that treating the nematodes with caffeine and/or taurine will result in a statistically significant decrease in the number of taps required to induce a habitual response and for the mutant nematodes to associate it as a non-harmful stimulus. This would suggest an improvement in memory and neurodegenerative dysfunction. METHODS: This was an observational study assessing the effects of caffeine and taurine administration and improvements in neurodegenerative dysfunction in a dose-dependent manner. The primary endpoint was the number of taps required to induce habituation and theoretically improve learning and movement in C. elegans. For comparison, we assessed anterior and posterior habituation following exposure to caffeine or taurine by tapping the worms with a sterile eyelash until the nematodes recognized the taps as a non-threatening stimulus. Control and mutant C. elegans were treated with 250μL of caffeine or taurine separately, at the following drug concentrations: 0μg/mL(control), 1μg/mL, 10μg/mL, 250μg/mL, and 500μg/mL. RESULTS: Thirty nematodes were tapped on the anterior and posterior ends after application of caffeine and/or taurine at varying concentrations. Current preliminary results indicate a significant decrease in the number of taps required for habituation in the mutant ynIs-79 C. elegans strain, comparatively. Statistical analysis included a one-way ANOVA and Dunnett’s multiple comparison test for repeated measures using Prism. CONCLUSION: The administration of caffeine towards mutant ynIs-79 C. elegans leads to improvements in observed neurodegenerative dysfunction at higher concentrations of caffeine by reducing the threshold required to induce habituation. However, administration of taurine does not reflect a dose-dependent reduction in the number of taps required to elicit habituation. Rather, administration of taurine at minimal concentrations is sufficient to achieve the desired effect. Repeated studies are needed to provide for targeted assessment of anterior and posterior response to tap habituation separately. Testing the same worm for both anterior and posterior response may provide for overstimulation of the nematode and reflect increased variability in the data

    Implementation of the National Curriculum for physical development in the reception year

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    This study explored how Grade R teachers at a pre-primary school understand and implement early childhood physical development practices, based on the Revised National Curriculum Statement (RNCS) for Grade R. The research took place in the form of a case study at a private pre-primary school in Rivonia, Sandton. Data was collected by means of document analysis of the RNCS for Grade R, a focus group discussion with purposefully selected participants and observations within the school. Analysis of the data was twofold, firstly utilising taxonomic analysis based on Anita Harrow‟s (1972) taxonomy of psychomotor learning (which formed the theoretical framework for the study), and secondly by means of a thematic analysis of data. Results and findings indicate that participants attributed significant importance to physical development in early childhood as a building block for the development of further cognitive skills and academic achievement. Participants demonstrated an in-depth and extensive comprehension of physical development pertaining to early childhood and their understanding thereof is reflected in their teaching practices offering varying opportunities and ways in which to learn. The school takes a whole-school approach to physical development by incorporating it into different contexts and enlisting the assistance of various role-players. Emerging themesreflect concern with the impact of modern lifestyle on children's physical development, current inadequacies of physical education programmes in schools, the need for teachers to remain informed and educated in physical development and the need for further development of the physical development section of the Grade R RNCS. Participants had various concerns with the curriculum in terms of what they perceived as its non-specificity, the participative versus quality performance approach, the lack of age-appropriate norms, and perceived irregularities with other areas of the Grade R curriculum. As a result, participants seemingly relied to a lesser extent on the RNCS to inform their implementation of physical development practices, relying instead on other sources of guidance. Participants therefore felt that the physical development section of the Grade R RNCS does not provide sufficient guidance and information for newly qualified or inexperienced teachers, especially those who have limited access to resources. Subsequently, this study highlights the need for teacher training as a means of improving the status of school physical education, assistance with and dissemination of information regarding early physical development in educational psychology practice and the need for further research in early physical development and the RNCS.Dissertation (MEd)--University of Pretoria, 2010.Educational Psychologyunrestricte

    Post-implementation assessment of novel rodent control devices for protection of high elevation endangered species at Hawai`i Volcanoes National Park

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    Reports were scanned in black and white at a resolution of 600 dots per inch and were converted to text using Adobe Paper Capture Plug-in.Invasive species, including rats, threaten the existence of many of Hawai`i’s native species pushing them to the brink of extinction. Hawai`i Volcanoes National Park has a long history of successfully managing ecosystems and providing rare species habitat through systematic invasive species control. Landscape level rodent control is prohibitively expensive; however, localized control has proven cost-effective while providing significant resource benefit. A trapping program using self-resetting Goodnature® A24 technology was implemented at two remote sites in Hawai`i Volcanoes National Park in an effort to protect five endangered plant species and three endangered bird species from black rat (Rattus rattus) predation. This trapping method has been successfully implemented on other islands, but implementation requirements are site specific. Techniques and maintenance schedules were investigated specifically for subalpine dry shrubland environments and also high elevation wet forest environments. Trap performance, recommended grid spacing, and a new chocolate long-life lure formula were evaluated over the course of this investigation. Apparent rodent control trends and subsequent native species responses were captured over the course of four months by conducting biweekly trap visits and analyzing motion triggered camera footage. Clear declines in rodent activity were documented at each site during the four month intensive monitoring period. At least 38 rodents were removed from the subalpine dry shrubland test site during this period, while at the high elevation wet forest site at least 102 rodents were removed. It is suspected that the number of total kills was underestimated using available monitoring techniques. Trapping activity appeared to prevent major damage to flowers and diminish damage to fruit of endangered Campanulaceae species at the forested test site, however it is unclear what effect trapping efforts had on native bird species at the subalpine shrubland site. Management recommendations differ by site. For subalpine shrubland sites, trap spacing should not exceed 100m x 100m to control M. musculus or R. rattus; tighter spacing may be necessary. In high elevation wet forests spacing traps at 50m x 50m is recommended to effectively reduce R. rattus populations. Pre-baiting traps is not advised to minimize potential damage done by rodents gnawing on depressurized traps. Concurrent trapping for feral cats and other scavengers, or strategic trapping schedules, are recommended to mitigate potential secondary predator attraction for sensitive sites such as Hawaiian petrel nesting areas. Schedule of trap maintenance should include monthly lure checks and ‘refreshment’ squeezes, regardless of site ecosystem. Scent of the lure diminishes between refreshment visits in arid environments and may be masked by algae or mold in wet environments. Use of the Goodnature® automatic lure pump should be considered to potentially alleviate this issue. In both environments standard lure bottles were found to last through the 16 week monitoring period. Lure was found to remain attractive to rodents, after refreshment squeezes as long as 36 weeks after deployment at the forested site. Trap maintenance should be scheduled to check CO2 status no later than 12 weeks after deployment, regardless of site ecosystem, to detect exhausted CO2 or malfunctioning traps, and at monthly maintenance visits if possible. Use of a surrogate pest such as a rubber rat to test fire through the trap shroud is advised to accurately simulate a strike, and ensure functionality of digital strik
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