Vaudoué – Ancienne commanderie des Templiers de Fourches

Jusqu’en 1973, seules les ruines de la chapelle et une cave à moitié comblée matérialisaient l’emplacement de l’ancienne commanderie des Templiers de Fourches en Gatinais, située sur la commune du Vaudoué. Les campagnes de fouilles entreprises pendant plusieurs années par le Centre de recherche et de documentation médiévales et archéologiques de Saint-Mammès, avaient permis la localisation et l’exploration d’un secteur du cimetière, la découverte d’un bâtiment supposé abriter les lépreux, un..

Experimental study of bidirectional seiching in an open-channel, lateral cavity in the time and frequency domain

This experimental laboratory study presents a detailed analysis of the surface oscillations inside a square cavity connected laterally to an open channel. For an approaching steady and one-dimensional main stream with a high (subcritical) Froude number, interaction with the dead water volume in the cavity area triggers high-amplitude free-surface oscillations, denoted seiches. In the present study, the length of the square cavity equals half of the combined width of the cavity and the main channel. This particular geometry enables two-dimensional or bidirectional seiching with standing waves being excited in both directions simultaneously. In this work, the (relative) magnitude of the different seiching modes (transverse and longitudinal) is measured and analyzed for a range of flow conditions with varying Froude number. The current experimental results confirm earlier findings indicating that the magnitude and dominance of the longitudinal seiching mode (with respect to the transverse mode) grows with increasing Froude number of the main stream. Additionally, a wavelet analysis in the time and frequency domains reveals that the amplitude of the two modes fluctuates significantly in the course of a single experiment, such that seiching cannot be considered a steady phenomenon. Therefore, two alternative strategies are presented to quantify the amplitude of both modes using a more time-localized approach that is less affected by the intermittent behavior of seiching. Although more research is necessary to fully understand what determines the dominant mode at a given moment, an in-depth analysis of the surface recordings at multiple locations in the cavity suggests that the transition from transverse to longitudinal seiching (and vice versa) is related to the phase difference between the bidirectional seiching waves at the (inner) corners of the cavity

Design study and first performance simulation of the ELT/MICADO focal plane coronagraphs

In this paper, we present the design and the expected performance of the classical Lyot coronagraph for the high contrast imaging modes of the wide-field imager MICADO. MICADO is a near-IR camera for the Extremely Large Telescope (ELT, previously E-ELT), with wide-field, spectroscopic and coronagraphic capabilities. MICADO is one of the first-light instruments selected by the ESO. Optimized to work with a multi-conjugate adaptive optics corrections provided by the MOARY module, it will also come with a SCAO correction with a high-level, on-axis correction, making use of the M4 adaptive mirror of the telescope. After presenting the context of the high contrast imaging modes in MICADO, we describe the selection process for the focal plane masks and Lyot stop. We will also show results obtained in realistic conditions, taking into account AO residuals, atmospheric refraction, noise sources and simulating observations in angular differential imaging (ADI) mode. Based on SPHERE on-sky results, we will discuss the achievable gain in contrast and angular separation provided by MICADO over the current instruments on 10-m class telescopes, in particular for imaging young giant planets at very short separations around nearby stars as well as planets on wider orbits around more distant stars in young stellar associations.Comment: 10 pages, 5 figures, AO4ELT 5 conference proceedin

Morphology of the gas-rich debris disk around HD 121617 with SPHERE observations in polarized light

Debris disks are the signposts of collisionally eroding planetesimal circumstellar belts, whose study can put important constraints on the structure of extrasolar planetary systems. The best constraints on the morphology of disks are often obtained from spatially resolved observations in scattered light. Here, we investigate the young (~16 Myr) bright gas-rich debris disk around HD121617. We use new scattered-light observations with VLT/SPHERE to characterize the morphology and the dust properties of this disk. From these properties we can then derive constraints on the physical and dynamical environment of this system, for which significant amounts of gas have been detected. The disk morphology is constrained by linear-polarimetric observations in the J band. Based on our modeling results and archival photometry, we also model the SED to put constraints on the total dust mass and the dust size distribution. We explore different scenarios that could explain these new constraints. We present the first resolved image in scattered light of the debris disk HD121617. We fit the morphology of the disk, finding a semi-major axis of 78.3$\pm$0.2 au, an inclination of 43.1$\pm$0.2{\deg} and a position angle of the major axis with respect to north, of 239.8$\pm$0.3{\deg}, compatible with the previous continuum and CO detection with ALMA. Our analysis shows that the disk has a very sharp inner edge, possibly sculpted by a yet-undetected planet or gas drag. While less sharp, its outer edge is steeper than expected for unperturbed disks, which could also be due to a planet or gas drag, but future observations probing the system farther from the main belt would help explore this further. The SED analysis leads to a dust mass of 0.21$\pm$0.02 M$_{\oplus}$ and a minimum grain size of 0.87$\pm$0.12 $\mu$m, smaller than the blowout size by radiation pressure, which is not unexpected for very bright col...Comment: 12 pages, 7 figures. Accepted in A&A (06/02/2023

190: In how many patients with Wolff-Parkinson-White syndrome-related adverse presentation isoproterenol infusion was required to reproduce the arrhythmia?

Electrophysiological study is the main method for the detection of patients with a Wolff-Parkinson-White syndrome (WPW) at risk of adverse presentation (resuscitated ventricular fibrillation (VF), documented life-threatening arrhythmia): the protocol is debated. The purpose of the study was to look in how many patients with WPW-related adverse presentation, atrial fibrillation (AF) or atrial tachycardia with the shortest RR cycle length (CL) with 1/1 conduction over accessory pathway (AP)<250msec was induced in control state (CS) and when isoproterenol was required.Methods63 patients, mean age 38±18, were referred for WPW-related adverse presentation (VF 6, other 56). EPS included in CS atrial pacing and measurement of the shortest CL with 1/1 conduction over AP and programmed stimulation with 1 and 2 extrastimuli. AP effective refractory period (ERP) was determined. In absence of induction of a tachycardia with a CL <250msec, isoproterenol (0.02 to 1μg. min-1) was infused to increase sinus rate to 130bpm; the protocol was repeated.ResultsMean shortest CL conducted over AP was 223±30msec in CS, 192±25msec after isoproterenol. APERP was 225±29msec in CS, 191±19msec after isoproterenol. Atrioventricular orthodromic tachycardia (AVRT) was induced in 34 patients (54%), antidromic tachycardia (ATD) in 13 (21%), AF in 43 (68%). Criteria for a malignant form (induction of AF or ATD with a shortest CL <250mesc) were noted in 42 patients (67%) in CS and were obtained after isoproterenol in remaining 21 patients (33%). Among these patients, 12 had inducible tachycardia in CS (AVRT (n=6), ATD (n=3), AF (n=3) but the shortest CL was >240msec. A tachycardia was only induced after isoproterenol in 9 patients (14%).ConclusionsInfusion of isoproterenol should be systematic when WPW is evaluated. EPS performed only in CS missed at least 14% of patients at risk of life-threatening arrhythmias who had no inducible supraventricular tachyarrhythmia and 33% of patients with a WPW without the classical criteria for a malignant form. Isoproterenol increased the sensitivity of EPS for the detection of malignant form from 67 to 100%

Heterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment

We previously observed increased levels of adenosine-deaminase-acting-on-dsRNA (Adar)-dependent RNA editing during mesothelioma development in mice exposed to asbestos. The aim of this study was to characterize and assess the role of ADAR-dependent RNA editing in mesothelioma. We found that tumors and mesothelioma primary cultures have higher ADAR-mediated RNA editing compared to mesothelial cells. Unsupervised clustering of editing in different genomic regions revealed heterogeneity between tumor samples as well as mesothelioma primary cultures. ADAR2 expression levels are higher in BRCA1-associated protein 1 wild-type tumors, with corresponding changes in RNA editing in transcripts and 3'UTR. ADAR2 knockdown and rescue models indicated a role in cell proliferation, altered cell cycle, increased sensitivity to antifolate treatment, and type-1 interferon signaling upregulation, leading to changes in the microenvironment in vivo. Our data indicate that RNA editing contributes to mesothelioma heterogeneity and highlights an important role of ADAR2 not only in growth regulation in mesothelioma but also in chemotherapy response, in addition to regulating inflammatory response downstream of sensing nucleic acid structures

Cross-shell states in 15^{15}C: a test for p-sd interactions

The low-lying structure of $^{15}$C has been investigated via the neutron-removal $^{16}$C$(d,t)$ reaction. Along with bound neutron sd-shell hole states, unbound p-shell hole states have been firmly confirmed. The excitation energies and the deduced spectroscopic factors of the cross-shell states are an important measure of the $[(p)^{-1}(sd)^{2}]$ neutron configurations in $^{15}$C. Our results show a very good agreement with shell-model calculations using the SFO-tls interaction for $^{15}$C. However, a modification of the $p$-$sd$ and $sd$-$sd$ monopole terms was applied in order to reproduce the $N=9$ isotone $^{17}$O. In addition, the excitation energies and spectroscopic factors have been compared to the first calculations of $^{15}$C with the $ab~ initio$ self-consistent Green's function method employing the NNLO$_{sat}$ interaction. The results show the sensitivity to the size of the $N=8$ shell gap and highlight the need of going beyond the current truncation scheme in the theory