Korelasi Skor Lund-Mackay dan Volume Cairan Sinus Berdasarkan Gambaran CT-Scan Sinus Paranasalis 3D dengan Skor SNOT-22 pada Pasien RSK Tanpa dan dengan Polip

The aim of this study is to determine the correlation between Lund-Mackay scores and sinus fluid volume based on 3D CT paranasal sinus scan with SNOT-22 score in patients with chronic rhinosinusitis without and with polyps. This research was conducted at the Department of Radiology Hasanuddin University Hospital Makassar from April to June 2019. Samples were 38 patients without and with polyps in age ? 18 years. The method used is the Spearman rho test. The results showed a correlation between sinus fluid volume and SNOT-22 score in patients with chronic rhinosinusitis without polyps n = 25, p = 0.042 (p 0.05), the higher the sinus fluid volume, means the SNOT-22 score was higher in patients with chronic rhinosinusitis without polyps. There was no correlation between sinus fluid volume and SNOT-22 score in patients with chronic rhinosinusitis with polyps n = 13, p = 0.077 (p 0.05), there was not any correlation between Lund-Mackay scores and SNOT-22 scores in patients with chronic rhinosinusitis without and with polyps

IL-1β Expression of Patients with Chronic Rhinosinusitis is negatively correlated with Lund-Mackay score

Introduction: IL-1β is one of the proinflammatory cytokines which is commonly found in various diseases, including Chronic Rhinosinusitis (CRS). It has been widely targeted as a therapeutic approach for inflammatory diseases. However, study of IL-1β expression and its correlation with CT-Scan grading scores in CRS is still scarce. Objective: To investigate IL-1β expression based on immunohistochemical examination and analyse its correlation with Lund-Mackay score in CRS with and without polyps. Method: This analytic observational study was done on 50 patients: 25 subjects in the CRS with Nasal Polyps (CRSwNP) group and 25 subjects in the CRS without Nasal Polyps (CRSsNP) group. The uncinate process was taken for immunohistochemical examination of IL-1β. Lund-Mackay score was calculated based on CT-Scan of the paranasal sinus. Result: IL-1β expression in CRSsNP (mean=36.38) was significantly higher than that in the CRSwNP (mean=14.62) with p<0.001. Lund-Mackay score in CRSwNP was higher (mean=35.22) compared to CRSnNP group (mean=15.78) with p<0.001. There was a moderate negative correlation (-0.403) between IL-1β expression and Lund-Mackay score (p<0.05). Conclusion: There was a moderate negative correlation between IL-1β expression and Lund-Mackay score. The IL-1β and the Lund-Mackay score in CRSwNP were lower and higher, respectively, than in CRSsN

Comparison of The Means of Argyrophilic Nucleolar Organizer Region (mAgNOR) Pre- and Post-Therapy in Nasopharyngeal Carcinoma Patients at Wahidin Sudirohusodo General Hospital Makassar

BACKGROUND: Nasopharyngeal carcinoma (NPC) is malignant tumor growing in nasopharynx with a predilection in fossa Rossenmuller and nasopharyngeal roof. This research aimed to prove whether the means of argyrophilic nucleolar organizer region (mAgNOR) can predict the success of treatment in nasopharyngeal carcinoma patients.METHODS: We used diagnostic test method with longitudinal design and purposive sampling technique. Endoscopic biopsy examination was performed on 15 nasopharyngeal carcinoma patients before and after therapy, 13 patients underwent chemotherapy and other two underwent chemoradiotherapy. Tumor tissues were stained and AgNOR was calculated.RESULTS: Based on the tumor stage, sample characteristic showed 3 patients (20%) were in stage II, 3 patients (20%) in stage III, and 9 patients (60%) in stage IV, with pre- and post-therapy mAgNOR were 1.610±0.988 and 1.000±0.000, respectively in stage II, 1.100±0.092 and 1.000±0.000, respectively in stage III, 1.226±0.265 and 1.107±0.164, respectively in stage IV patients. Based on histopathology type, 4 patients (26.7%) had non keratinizing squamous cell carcinoma with pre- and post-therapy mAgNOR were 1.117±0.134 and 1.060±0.120, respectively, while 11 patients (73.3%) had undifferentiated squamous cell carcinoma with pre- and post-therapy mAgNOR were 1.335±0.528 and 1.065±0.146, respectively. Overall the pre-therapy were significantly higher than post-therapy mAgNOR. In subgroups there are significant differences in stage IV and type 3.CONCLUSION: The values of AgNOR were decreased in all NPC stages and significantly decreased in undifferentiated squamous cell carcinoma. AgNOR can be used to predict the successfulness of therapy in NPC.KEYWORDS: nasopharyngeal carcinoma, therapy, proliferation, mAgNO

Endoscopic transsphenoidal surgery and Haddad nasoseptal flap of Rathke’s cleft cysts

Introduction: Rathke’s cleft cysts (RCC) grow formed from remnants of the embryologic Rathke’s pouch and are often found incidentally in the sellar or suprasellar region. These lesions are usually asymptomatic in most people. However, as the cyst progressively enlarges, they may develop symptoms typical of RCC, including headache, vision loss, and endocrine dysfunction. The diagnosis procedure involves an MRI scan of the pituitary gland. The endoscopic transsphenoidal approach has become the most common surgical approach to treat RCC. In the last 15 years, endonasal endoscopy has been widely used in the surgical management of these lesions. Case report: A 58-year-old Asian woman was reported mainly with a complaint of headache that had increased over the last two months, occasional nausea and vomiting, and blurred vision experienced for 1 month

A case report on attempted suicide by self-slitting resulting in laryngeal fracture

Introduction: Laryngeal fractures cause significant problems with airway patency, vocal production, and swallowing function. The mechanism of injury can be sharp or blunt and can occur in the supraglottic, glottic, or infraglottic regions. Blunt external trauma to the neck caused by motor vehicle accidents, sports-related trauma, assault, and strangulation are the most frequent causes of laryngeal ruptures and fractures. Penetrating trauma is the second leading cause, often due to gunshot or stab wounds to the neck. The immediate goal in patients presenting to the emergency department with laryngeal rupture is to secure the airway. One of the indications for tracheostomy placement includes acute respiratory failure with the need for prolonged mechanical ventilation

Isolated fungal sinusitis of the sphenoid sinus - A case report

Introduction: Isolated sphenoidal fungal sinusitis is a rare disease, representing 3% of all sinusitis cases. The disease usually occurs together with other paranasal sinus infections. Viral, bacterial, parasitic, and fungal infections can cause sinusitis. Fungal infection of the sphenoidal sinuses is rarely diagnosed, as it has no characteristic symptoms and is not much different from bacterial or other sinusitis infections. The diagnosis of fungal sphenoid sinusitis is based on history taking, physical examination, and supporting examination. The therapy aims to reduce sinus cavity inflammation, improve drainage, and overcome the pressure on the sinuses that cause painful symptoms. Endoscopic Sinus Surgery (ESS) is a surgical technique on the paranasal sinuses using an endoscope that aims to improve ventilation and mucociliary clearance of the sinuses

Endoscopic dacryocystorhinostomy as treatment for lacrimal pathway obstructions: Serial case reports

Introduction: The lacrimal system is an important system for maintaining the normal condition of the ocular surface. Obstruction of the lacrimal duct can lead to inflammation and accumulation of debris and pathogens such as bacteria or fungi in the lacrimal sac and then cause dacryocystitis. This disease is often found in children or adults over 40 years of age, especially women with a peak incidence at the age of 60 to 70 years. Complaints usually include eye discomfort and redness accompanied by excessive tears. The diagnosis can be made based on physical examination, staining tests, and imaging photographs, such as dacryocystography, computed tomography (CT), and magnetic resonance imaging (MRI). Management of dacryocystitis is conservative, supportive, and surgical with an open or endonasal approach

The Examination of Olfactory Function and Mucocilliary Transport in Gas Station Officers in Makassar, Indonesia

Introduction: Chronic exposure to fuel oil can cause chemical burns to the olfactory epithelium, which can cause anosmia. This study aimed to compare mucociliary transport time and olfactory function between operator and non-operator officers at gas stations. Methods: This cross-sectional study was conducted from September to November 2020 and involved 40 subjects divided into two equal groups each consisting of 20 gas station operators and non-operators, respectively. The examination of mucociliary transport time was carried out by saccharin test, while the olfactory function was examined by assessing e olfactory threshold, discrimination, and identification (TDI) score using the Sniffin sticks test. Results: There was a significant difference in the mean mucociliary transport time and olfactory function between gas station operators and non-operators (P<0.001). In addition, there was also a significant correlation between the mucociliary transit time and olfactory function (p<0.05), with a strong negative correlation coefficient (r=-0.620). Therefore, the longer the mucociliary transit time, the gas station attendant's olfactory function will decrease. Conclusion: mucociliary transport time and olfactory function in non-operator public gas station officers were better than operators, probably because inhalation of chemical pollutants induces the release of proinflammatory cytokines, chronic inflammation of the nasal mucosa results in impaired olfactory cells and mucin glands