A clustering based technique for large scale prioritization during requirements elicitation

We consider the prioritization problem in cases where the number of requirements to prioritize is large using a clustering technique. Clustering is a method used to find classes of data elements with respect to their attributes. KMeans, one of the most popular clustering algorithms, was adopted in this research. To utilize k-means algorithm for solving requirements prioritization problems, weights of attributes of requirement sets from relevant project stakeholders are required as input parameters. This paper showed that, the output of running k-means algorithm on requirement sets varies depending on the weights provided by relevant stakeholders. The proposed approach was validated using a requirement dataset known as RALIC. The results suggested that, a synthetic method with scrambled centroids is effective for prioritizing requirements using k-means clustering

Compatibility of radial, Lorenz and harmonic gauges

We observe that the radial gauge can be consistently imposed \emph{together} with the Lorenz gauge in Maxwell theory, and with the harmonic traceless gauge in linearized general relativity. This simple observation has relevance for some recent developments in quantum gravity where the radial gauge is implicitly utilized.Comment: 9 pages, minor changes in the bibliograph

Many-nodes/many-links spinfoam: the homogeneous and isotropic case

I compute the Lorentzian EPRL/FK/KKL spinfoam vertex amplitude for regular graphs, with an arbitrary number of links and nodes, and coherent states peaked on a homogeneous and isotropic geometry. This form of the amplitude can be applied for example to a dipole with an arbitrary number of links or to the 4-simplex given by the compete graph on 5 nodes. All the resulting amplitudes have the same support, independently of the graph used, in the large j (large volume) limit. This implies that they all yield the Friedmann equation: I show this in the presence of the cosmological constant. This result indicates that in the semiclassical limit quantum corrections in spinfoam cosmology do not come from just refining the graph, but rather from relaxing the large j limit.Comment: 8 pages, 4 figure

Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: Functional and therapeutic implications

This article is made available through the Brunel Open Access Publishing Fund. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.CLU (clusterin) is a tumor suppressor gene that we have previously shown to be negatively modulated by the MYCN proto-oncogene, but the mechanism of repression was unclear. Here, we show that MYCN inhibits the expression of CLU by direct interaction with the non-canonical E box sequence CACGCG in the 5′-flanking region. Binding of MYCN to the CLU gene induces bivalent epigenetic marks and recruitment of repressive proteins such as histone deacetylases and Polycomb members. MYCN physically binds in vitro and in vivo to EZH2, a component of the Polycomb repressive complex 2, required to repress CLU. Notably, EZH2 interacts with the Myc box domain 3, a segment of MYC known to be essential for its transforming effects. The expression of CLU can be restored in MYCN-amplified cells by epigenetic drugs with therapeutic results. Importantly, the anticancer effects of the drugs are ablated if CLU expression is blunted by RNA interference. Our study implies that MYC tumorigenesis can be effectively antagonized by epigenetic drugs that interfere with the recruitment of chromatin modifiers at repressive E boxes of tumor suppressor genes such as CLU.SPARKS, The Neuroblastoma Society, a Wellcome Trust grant (to A. S.), and the Italian Association for Cancer Research

Summary of the CMS Discovery Potential for the MSSM SUSY Higgses

This work summarises the present understanding of the expected MSSM SUSY Higgs reach for CMS. Many of the studies presented here result from detailed detector simulations incorporating final CMS detector design and response. With 30 fb-1 the h -> gamma,gamma and h -> bb channels allow to cover most of the MSSM parameter space. For the massive A,H,H+ MSSM Higgs states the channels A,H -> tau,tau and H+ -> tau,nu turn out to be the most profitable ones in terms of mass reach and parameter space coverage. Consequently CMS has made a big effort to trigger efficiently on taus. Provided neutralinos and sleptons are not too heavy, there is an interesting complementarity in the reaches for A,H -> tau,tau and A,H -> chi,chi.Comment: 19 pages, 27 figure

DC and AC Electrical Characterization of Stacks of HTS Tapes

Today the Bi-2223 tape represents a suitable candidate for the use in various HTS devices. The LHC current leads use Bi-2223 tapes soldered together in short lengths, forming stacks of rugged HTS conductors. Critical current and AC loss measurements were performed on BSCCO stacks, in the temperature range of 65 K and 77 K and in magnetic fields of up to 0.5 T. The experimental results reported in this paper give a broad description of the stacks behavior in the range of current and field values of practical interest, and provide design parameters for the optimization of current leads operating both in DC and pulsed conditions

Development and Manufacture of the Coil End Spacers of the LHC Pre-series Dipoles

The coil end spacers play an important role in the performance of superconducting coils, as their shape and location determine the mechanical stability of the conductors in the coil ends (and hence the overall coil training performance) and the local field quality. The dipole end spacers are often of a size and a geometry difficult to be industrially series manufactured and measured. Efficiency of the production and related costs are a key issue to achieve the required production rate of the LHC main dipoles at an affordable price. For the latter reasons, a design approach integrating state-of-the-art CAD/CAM optimization techniques allowing to considerably decrease design and machining time was implemented. This paper gives examples and describes the design criteria, the computation methods, the machining and measuring procedures adopted to carry out the pre-series production

Analyzing requirements of knowledge management systems with the support of agent organizations

Knowledge Management (KM) is considered by many organizations a key aspect in sustaining competitive advantage. Designing appropriate KM processes and enabling technology face considerable risks, as they must be shaped to respond to specific needs of the organizational environment. Thus, many systems are abandoned or fall into disuse because of inadequate understanding of the organizational context. This motivates current research, which tends to propose agent organizations as a useful paradigm for KM systems engineering. Following these approaches, organizations are analyzed as collective systems, composed of several agents, each of them autonomously producing and managing their own local data according to their own logic, needs, and interpretative schema, i.e. their goals and beliefs. These agents interact and coordinate for goal achievement defining a coherent local knowledge system. This paper presents a novel methodology for analyzing the requirements of a KM system based on an iterative workflow where a pivotal role is played by agent-oriented modeling. Within this approach, the needs for KM systems are traced back to the organization stakeholders’ goals. A case study is used to illustrate the methodology. The relationship of this work with current studies in agent organizations and organizational knowledge management is also discussed. Differently from other works, this methodology aims at offering a practical guideline to the analyst, pointing out the appropriate abstractions to be used in the different phases of the analysis

Design Features and Performance of a 10 T Twin Aperture Model Dipole for LHC

A twin-aperture superconducting (sc) dipole model has been designed in collaboration with Finnish and Swedish Institutions and built at CERN. The cable critical current was attained at a central field of 10.5 T at a temperature of 1.77 K after three training quenches only. This model has shown a very good quench performance as well as a robust mechanical behavior over several thermal cycles. This p aper will discuss the design, the innovations of the mechanical structure, and the results obtained during the intensive campaigns of tests

Power Test Results of the First LHC Second Generation Superconducting Single Aperture 1m Long Dipole Models

Within the LHC magnet research and development programme, a series of single aperture 1m long models of second generation are presently being built and tested at CERN. The main features of these magnets are: five-block, two layer coils wound from 15mm wide graded NbTi cables, enlarged 56mm aperture and all-polyimide insulation. This paper reviews the power test data of magnets tested to date in both supercritical and superfluid helium. The results of the quench training, the initial location and propagation of quenches and their sensitivity to energy extraction are presented and discussed in terms of the design parameters and the aims of this short dipole model test program