12,455 research outputs found
Freshly Formed Dust in the Cassiopeia A Supernova Remnant as Revealed by the Spitzer Space Telescope
We performed Spitzer Infrared Spectrograph mapping observations covering
nearly the entire extent of the Cassiopeia A supernova remnant (SNR), producing
mid-infrared (5.5-35 micron) spectra every 5-10". Gas lines of Ar, Ne, O, Si, S
and Fe, and dust continua were strong for most positions. We identify three
distinct ejecta dust populations based on their continuum shapes. The dominant
dust continuum shape exhibits a strong peak at 21 micron. A line-free map of 21
micron-peak dust made from the 19-23 micron range closely resembles the [Ar
II], [O IV], and [Ne II] ejecta-line maps implying that dust is freshly formed
in the ejecta. Spectral fitting implies the presence of SiO2, Mg
protosilicates, and FeO grains in these regions. The second dust type exhibits
a rising continuum up to 21 micron and then flattens thereafter. This ``weak 21
micron'' dust is likely composed of Al2O3 and C grains. The third dust
continuum shape is featureless with a gently rising spectrum and is likely
composed of MgSiO3 and either Al2O3 or Fe grains. Using the least massive
composition for each of the three dust classes yields a total mass of 0.02
Msun. Using the most-massive composition yields a total mass of 0.054 Msun. The
primary uncertainty in the total dust mass stems from the selection of the dust
composition necessary for fitting the featureless dust as well as 70 micron
flux. The freshly formed dust mass derived from Cas A is sufficient from SNe to
explain the lower limit on the dust masses in high redshift galaxies.Comment: 8 figures: Accepted for the publication in Ap
Evidence Against the Sciama Model of Radiative Decay of Massive Neutrinos
We report on spectral observations of the night sky in the band around 900
angstroms where the emission line in the Sciama model of radiatively decaying
massive neutrinos would be present. The data were obtained with a high
resolution, high sensitivity spectrometer flown on the Spanish MINISAT
satellite. The observed emission is far less intense than that expected in the
Sciama model.Comment: 9 pages, accepted to Ap
Albumin-induced apoptosis of tubular cells is modulated by BASP1
Albuminuria promotes tubular injury and cell death, and is associated with faster progression of chronic kidney disease (CKD) to
end-stage renal disease. However, the molecular mechanisms regulating tubular cell death in response to albuminuria are not fully
understood. Brain abundant signal protein 1 (BASP1) was recently shown to mediate glucose-induced apoptosis in tubular cells.
We have studied the role of BASP1 in albumin-induced tubular cell death. BASP1 expression was studied in experimental
puromycin aminonucleoside-induced nephrotic syndrome in rats and in human nephrotic syndrome. The role of BASP1 in
albumin-induced apoptosis was studied in cultured human HK2 proximal tubular epithelial cells. Puromycin aminonucleoside
induced proteinuria and increased total kidney BASP1 mRNA and protein expression. Immunohistochemistry localized the
increased BASP1 to tubular cells. BASP1 expression colocalized with deoxynucleotidyl-transferase-mediated dUTP nick-end
labeling staining for apoptotic cells. Increased tubular BASP1 expression was observed in human proteinuric nephropathy by
immunohistochemistry, providing evidence for potential clinical relevance. In cultured tubular cells, albumin induced apoptosis
and increased BASP1 mRNA and protein expression at 6–48 h. Confocal microscopy localized the increased BASP1 expression
in albumin-treated cells mainly to the perinuclear area. A peripheral location near the cell membrane was more conspicuous in
albumin-treated apoptotic cells, where it colocalized with actin. Inhibition of BASP1 expression by a BASP1 siRNA protected from
albumin-induced apoptosis. In conclusion, albumin-induced apoptosis in tubular cells is BASP1-dependent. This information may
be used to design novel therapeutic approaches to slow CKD progression based on protection of tubular cells from the adverse
consequences of albuminuriaGrant support: FIS PS09/00447, PI13/00047, CP14/
00133, ISCIII-RETIC, REDinREN/RD06/0016/and RD012/0021 FEDER funds,
Comunidad de Madrid/CIFRA S2010/BMD-2378. Salary support: FIS to MDSN
and ABS (Miguel Servet), Beatriz Fernandez-Fernandez (Rio Hortega). Programa
Intensificación Actividad Investigadora (ISCIII/Agencia Laín-Entralgo/CM) to AO.
IIS-FJD Biobank RD09/0076/0010
How to Improve the Functional Capacity of Frail and Pre-Frail Elderly People? Health, Nutritional Status and Exercise Intervention. The EXERNET-Elder 3.0 Project
Aging is associated with the impairment of health and functional capacity, and physical exercise seems to be an effective tool in frailty prevention and treatment. The purpose of this study was to present the methodology used in the EXERNET-Elder 3.0 project that aims to evaluate the immediate and residual effects and of a multicomponent exercise training program called Elder-fit on frailty, fitness, body composition and quality of life, and also to analyse a possible dietary intake interaction according to health and metabolic status. A total of 110 frail and pre-frail elders participated in this study and were divided into a control group (CG = 52) and an intervention group (IG = 58). The IG performed a supervised multicomponent exercise training program of 6 months and 3 days per week, which included strength, endurance, balance, coordination and flexibility exercises, while the CG continued with their usual daily activities. Both groups received four speeches about healthy habits along the project. Four evaluations were performed: at baseline, after 3 months of training, at the end of the training program (6 months) and 4 months after the program had ended to examine the effects of detraining. Evaluating the efficacy, safety and feasibility of this program will help to develop efficacious physical interventions against frailty. Further, protocols should be described accurately to allow exercise programs to be successfully replicated
Outbreak Of NDM-1-producing Klebsiella Pneumoniae In A Neonatal Unit In Colombia
Six multiresistant, NDM-1-producing Klebsiella pneumoniae strains were recovered from an outbreak that affected six neonatal patients in a Colombian hospital. Molecular analysis showed that all of the isolates harbored the blaNDM-1, qnrA, and intI1 genes and were clonally related. Multilocus sequence typing showed that the isolates belonged to a new sequence type (ST1043) that was different from the sequence types that had previously been reported. This is the first report of NDM-1-producing isolates in South America
Turbidity and Other Effects Resulting from Trafalgar Sandbank Dredging and Palmar Beach Nourishment
Beach-nourishment requirements on the southwestern Spanish coast have led to a significant increase in offshore dredging. Following a new research line, assessment of changes recorded in physicochemical and biological parameters due to dredging and dumping operations was performed at the Cape of Trafalgar and Palmar Beach during June and July 2008. Turbidity, salinity, pH, dissolved oxygen, temperature, and suspended-sediment data were collected at 10 stations. At the end of the study, a three-campaign monitoring program was implemented for 1 year to assess the possible effects on biological communities and sediment properties. The relevant results, such as the average extent of the sediment plume (< 400 m) and its persistence in the environment (< 10 min), are discussed in this paper. A precise correlation between turbidity and suspended sediments and the recovery time of ecological balance were also established. Furthermore, minimal and reversible effects caused by dredging and dumping operations in this type of marine environment were identified
Análisis de técnicas de relevamiento funcional de una vía rural expuesta a niebla
El presente estudio determina los ensayos a desarrollar para evaluar las características funcionales de la Ruta Nacional N° 33 circundante a la ciudad de Trenque Lauquen, las cuales se vinculan con el fenómeno de niebla/neblina en cuanto a la probabilidad de tránsito inseguro.
El trabajo se basa en valorar los métodos de ensayo aplicables a la región estudiada y la evaluación de los elementos técnicos que servirán para realizar las pruebas in situ.
Contando con estudios previos que determinan la gravedad de los eventos en función de la consecuencia en la salud de los participantes de siniestros y sumados los resultados obtenidos en la valoración, se realizarán los ensayos pertinentes en articulación con la Dirección Nacional de Vialidad determinando tramos críticos.
Estos conocimientos permitirán acciones como: el diseño de intervenciones en tareas de mejoras superficiales de la capa de rodamiento, la demarcación horizontal y el señalamiento vertical, iluminación y diseño geométrico.
Los ensayos seleccionados para una futura implementación y análisis son: la evaluación planialtimétrica del tramo establecido, ensayos de fricción y ensayos de textura superficial, que permiten cuantificar la macrotextura y microtextura superficial del asfalto. Además se propone la medición de los deterioros superficiales asociables a fisuras, desprendimientos, baches y ahuellamiento. Finalmente la propuesta aborda analizar la potencial demarcación existente y sistema de iluminación artificial.Fil: Perez Angueira, Luciana. Universidad Tecnológica Nacional. Facultad Regional Trenque Lauquen; ArgentinaFil: Martínez Micakoski, Fernanda B.. Universidad Tecnológica Nacional; ArgentinaFil: Rapallini, José. Universidad Tecnológica Nacional. Facultad Regional La Plata. Departamento de Ingeniería en Sistemas de Información. CODAPLI; ArgentinaFil: Rivera, José Julián. Universidad Tecnológica Nacional. Facultad Regional La Plata. LEMaC; ArgentinaFil: Marcos, Carlos. Universidad Tecnológica Nacional; ArgentinaFil: Perez Angueira, Ángeles. Universidad Tecnológica Nacional. Facultad Regional Trenque Lauquen; ArgentinaFil: Gómez, Jonathan. Universidad Tecnológica Nacional; ArgentinaFil: Mechura, Verónica. Universidad Tecnológica Nacional. Facultad Regional La Plata. LEMaC; ArgentinaPeer Reviewe
INGA 3D - creative transfer of competence in 3D footwear CAD to VET professionals
INGA 3D project - Creative Transfer of Competence in 3D Footwear CAD to VET Professionals aims to transfer and extend innovative software solutions and 3D technologies for Footwear Computer Aided Design. The project brings together universities, research and training centres, adult education providers and IT companies from Romania, Spain, Portugal, and UK. The project products introduce innovative solutions for e-learning in order to test and to validate new teaching methodologies and approaches suitable for vocational training. The INGA 3D training content, its supportive guide as well as the online learning platform was designed, developed, tested and evaluated in line with the best practices identified by partners in their institutions, countries and elsewhere in Europe. INGA 3D project contributes to developing skills and competencies of VET teachers, trainers, tutors, in order to face the future challenges raised by the necessity of adding to the current curricula in VET institutions ICT skill sets that will enable their graduates to work with highly specialized footwear CAD technologies
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