Consumers’ willingness to pay for biodiesel in Spain

Consumer/Household Economics, Resource /Energy Economics and Policy,

Preferencias inciertas y modelo Spike en la valoración del patrimonio natural

Under the Spanish conservation law, compensation is envisaged for the damage associated with all actions that reduce the quantity or quality of protected areas and species. This paper provides a tool to evaluate the monetary equivalent of this damage. First, we conduct a contingent valuation exercise to estimate the existence value related to protected areas and species in Aragon. This first estimate is then reconsidered including in first place the possibility of zero bids and also the possibility of uncertain preferences for non familiar goods. Considering these two effects, mean values are reduced dramatically (more than halved) giving support to previous recommendations of dividing by two contingent valuation estimates from dichotomous choice question formats.Natural heritage; contingent valuation; Spike model; uncertainty

FacePET: Enhancing Bystanders\u27 Facial Privacy with Smart Wearables/Internet of Things

Given the availability of cameras in mobile phones, drones and Internet-connected devices, facial privacy has become an area of major interest in the last few years, especially when photos are captured and can be used to identify bystanders’ faces who may have not given consent for these photos to be taken and be identified. Some solutions to protect facial privacy in photos currently exist. However, many of these solutions do not give a choice to bystanders because they rely on algorithms that de-identify photos or protocols to deactivate devices and systems not controlled by bystanders, thereby being dependent on the bystanders’ trust in these systems to protect his/her facial privacy. To address these limitations, we propose FacePET (Facial Privacy Enhancing Technology), a wearable system worn by bystanders and designed to enhance facial privacy. We present the design, implementation, and evaluation of the FacePET and discuss some open research issues

A User Study of a Wearable System to Enhance Bystanders’ Facial Privacy

The privacy of users and information are becoming increasingly important with the growth and pervasive use of mobile devices such as wearables, mobile phones, drones, and Internet of Things (IoT) devices. Today many of these mobile devices are equipped with cameras which enable users to take pictures and record videos anytime they need to do so. In many such cases, bystanders’ privacy is not a concern, and as a result, audio and video of bystanders are often captured without their consent. We present results from a user study in which 21 participants were asked to use a wearable system called FacePET developed to enhance bystanders’ facial privacy by providing a way for bystanders to protect their own privacy rather than relying on external systems for protection. While past works in the literature focused on privacy perceptions of bystanders when photographed in public/shared spaces, there has not been research with a focus on user perceptions of bystander-based wearable devices to enhance privacy. Thus, in this work, we focus on user perceptions of the FacePET device and/or similar wearables to enhance bystanders’ facial privacy. In our study, we found that 16 participants would use FacePET or similar devices to enhance their facial privacy, and 17 participants agreed that if smart glasses had features to conceal users’ identities, it would allow them to become more popular

Highly efficient visible and near-IR photon pair generation with thin-film lithium niobate

Efficient on-chip entangled photon pair generation at telecom wavelengths is an integral aspect of emerging quantum optical technologies, particularly for quantum communication and computing. However, moving to shorter wavelengths enables the use of more accessible silicon detector technology and opens up applications in imaging and spectroscopy. Here, we present high brightness ($(1.6 \pm 0.3) \times 10^{9}$ pairs/mW/nm) visible-near-IR photon pair generation in a periodically poled lithium niobate nanophotonic waveguide. The degenerate spectrum of the photon pairs is centered at 811 nm with a bandwidth of 117 nm. The measured on-chip source efficiency of $(2.3\pm 0.5) \times 10^{11}$ pairs/mW is on par with source efficiencies at telecom wavelengths and is also orders of magnitude higher than the efficiencies of other visible sources implemented in bulk crystal or diffused waveguide-based technologies. These results represent the shortest wavelength of photon pairs generated in a nanophotonic waveguide reported to date by nearly an octave.Comment: Main text: 10 pages, 6 figures; Supplementary material: 5 pages, 3 figures. Author initials update

ESMO Clinical Research Observatory (ECRO): improving the efficiency of clinical research through rationalisation of bureaucracy

During the last years, there has been a dramatic increase in the administrative and bureaucratic burden associated with cli

Permanent Neonatal Diabetes Caused by Creation of an Ectopic Splice Site within the INS Gene

PublishedCase ReportsJournal ArticleResearch Support, Non-U.S. Gov'tBACKGROUND: The aim of this study was to characterize the genetic etiology in a patient who presented with permanent neonatal diabetes at 2 months of age. METHODOLOGY/PRINCIPAL FINDINGS: Regulatory elements and coding exons 2 and 3 of the INS gene were amplified and sequenced from genomic and complementary DNA samples. A novel heterozygous INS mutation within the terminal intron of the gene was identified in the proband and her affected father. This mutation introduces an ectopic splice site leading to the insertion of 29 nucleotides from the intronic sequence into the mature mRNA, which results in a longer and abnormal transcript. CONCLUSIONS/SIGNIFICANCE: This study highlights the importance of routinely sequencing the exon-intron boundaries and the need to carry out additional studies to confirm the pathogenicity of any identified intronic genetic variants.Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas (CIBERDEM)Instituto de Salud Carlos III of the Spanish Ministry of HealthFIS-programsWellcome Trus

In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19

Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively.Methods: We performed in silico analyses of immune system protein interactome network, single-cell RNA sequencing of human tissues, and artificial neural networks to reveal potential therapeutic targets for drug repurposing against COVID-19.Results: We screened 1,584 high-confidence immune system proteins in ACE2 and TMPRSS2 co-expressing cells, finding 25 potential therapeutic targets significantly overexpressed in nasal goblet secretory cells, lung type II pneumocytes, and ileal absorptive enterocytes of patients with several immunopathologies. Then, we performed fully connected deep neural networks to find the best multitask classification model to predict the activity of 10,672 drugs, obtaining several approved drugs, compounds under investigation, and experimental compounds with the highest area under the receiver operating characteristics.Conclusion: After being effectively analyzed in clinical trials, these drugs can be considered for treatment of severe COVID-19 patients. Scripts can be downloaded at