2,711 research outputs found
A Born-Infeld-like f(R) gravity
Several features of an theory in which there is a maximum value for
the curvature are analyzed. The theory admits the vaccuum solutions of GR, and
also the radiation evolution for the scale factor of the standard cosmological
model. Working in the Jordan frame, a complete analysis of the phase space is
performed, and its results supported with examples obtainted by numerical
integration. In particular, we showed that theory has nonsingular cosmological
solutions which after the bounce enter a phase of de Sitter expansion and
subsequently relax to a GR-like radiation-dominated evolution.Comment: Latex file, 14 pages, 7 figures (jpg format), including more detailed
discussions than previous version, accepted for publication in Physical
Review
Coastal upwelling in the Rias Bajas, NW Spain: Contrasting the benthic regimes of the Rias de Arosa and de Muros
Nutrient-rich North Atlantic water upwells off the NW coast of Spain and intermittently intrudes into the rias, coastal embayments, by displacement during periods of offshore winds. High primary production associated with the upwelling supports an intensive raft culture of the edible mussel, Mytilus edulis. This culture is most intensive (ca. 2000 rafts) in the Ria de Arosa, and results in one of the highest protein yields per unit area on earth...
Covariant Description of Flavor Conversion in the LHC Era
A simple covariant formalism to describe flavor and CP violation in the
left-handed quark sector in a model independent way is provided. The
introduction of a covariant basis, which makes the standard model approximate
symmetry structure manifest, leads to a physical and transparent picture of
flavor conversion processes. Our method is particularly useful to derive robust
bounds on models with arbitrary mechanisms of alignment. Known constraints on
flavor violation in the K and D systems are reproduced in a straightforward
manner. Assumptions-free limits, based on top flavor violation at the LHC, are
then obtained. In the absence of signal, with 100 fb^{-1} of data, the LHC will
exclude weakly coupled (strongly coupled) new physics up to a scale of 0.6 TeV
(7.6 TeV), while at present no general constraint can be set related to Delta
t=1 processes. LHC data will constrain Delta F=2 contributions via same-sign
tops signal, with a model independent exclusion region of 0.08 TeV (1.0 TeV).
However, in this case, stronger bounds are found from the study of CP violation
in D-bar D mixing with a scale of 0.57 TeV (7.2 TeV). In addition, we apply our
analysis to models of supersymmetry and warped extra dimension. The minimal
flavor violation framework is also discussed, where the formalism allows to
distinguish between the linear and generic non-linear limits within this class
of models.Comment: 24 pages, 6 figures. Some corrections and clarifications; references
added. Matches published versio
Transcriptomic differences in MSA clinical variants
Background: Multiple system atrophy (MSA) is a rare oligodendroglial synucleinopathy of unknown etiopathogenesis including two major clinical variants with predominant parkinsonism (MSA-P) or cerebellar dysfunction (MSA-C). Objective: To identify novel disease mechanisms we performed a blood transcriptomic study investigating differential gene expression changes and biological process alterations in MSA and its clinical subtypes. Methods: We compared the transcriptome from rigorously gender and age-balanced groups of 10 probable MSA-P, 10 probable MSA-C cases, 10 controls from the Catalan MSA Registry (CMSAR), and 10 Parkinson Disease (PD) patients. Results: Gene set enrichment analyses showed prominent positive enrichment in processes related to immunity and inflammation in all groups, and a negative enrichment in cell differentiation and development of the nervous system in both MSA-P and PD, in contrast to protein translation and processing in MSA-C. Gene set enrichment analysis using expression patterns in different brain regions as a reference also showed distinct results between the different synucleinopathies. Conclusions: In line with the two major phenotypes described in the clinic, our data suggest that gene expression and biological processes might be differentially affected in MSA-P and MSA-C. Future studies using larger sample sizes are warranted to confirm these results
A classification of the effective metric in nonlinear electrodynamics
We show that only two types of effective metrics are possible in certain
nonlinear electromagnetic theories. This is achieved by using the dependence of
the effective metric on the energy-momentum tensor of the background along with
the Segr\`e classification of the latter. Each of these forms is completely
determined by single scalar function, which characterizes the light cone of the
nonlinear theory. We compare this light cone with that of Minkowski in two
examples.Comment: Accepted for publication in Classical & Quantum Gravit
Genetic Variability of the Neogregarine Apicystis bombi, an Etiological Agent of an Emergent Bumblebee Disease
The worldwide spread of diseases is considered a major threat to biodiversity and a possible driver of the decline of pollinator populations, particularly when novel species or strains of parasites emerge. Previous studies have suggested that populations of introduced European honeybee (Apis mellifera) and bumblebee species (Bombus terrestris and Bombus ruderatus) in Argentina share the neogregarine parasite Apicystis bombi with the native bumblebee (Bombus dahlbomii). In this study we investigated whether A. bombi is acting as an emergent parasite in the non-native populations. Specifically, we asked whether A. bombi, recently identified in Argentina, was introduced by European, non-native bees. Using ITS1 and ITS2 to assess the parasite's intraspecific genetic variation in bees from Argentina and Europe, we found a largely unstructured parasite population, with only 15% of the genetic variation being explained by geographic location. The most abundant haplotype in Argentina (found in all 9 specimens of non-native species) was identical to the most abundant haplotype in Europe (found in 6 out of 8 specimens). Similarly, there was no evidence of structuring by host species, with this factor explaining only 17% of the genetic variation. Interestingly, parasites in native Bombus ephippiatus from Mexico were genetically distant from the Argentine and European samples, suggesting that sufficient variability does exist in the ITS region to identify continent-level genetic structure in the parasite. Thus, the data suggest that A. bombi from Argentina and Europe share a common, relatively recent origin. Although our data did not provide information on the direction of transfer, the absence of genetic structure across space and host species suggests that A. bombi may be acting as an emergent infectious disease across bee taxa and continents.Centro de Estudios ParasitolĂłgicos y de Vectore
Cambios alimentarios y de estilo de vida como estrategia en la prevenciĂłn del sĂndrome metabĂłlico y la diabetes mellitus tipo 2: hitos y perspectivas
El elevado aporte calĂłrico de la alimentaciĂłn actual y el sedentarismo, son los principales causantes
del notable incremento de la obesidad en nuestra sociedad. A su vez, esto conlleva un aumento de las patologĂas asociadas a ella, como pueden ser el sĂndrome metabĂłlico y la diabetes tipo 2. En el presente trabajo, han
sido revisados los estudios y programas más recientes
y significativos en cuanto a su tamaño muestral y a su
diversidad geográfica, poniendo de manifiesto que los
cambios en la alimentaciĂłn y en los estilos de vida,
son un instrumento efectivo para combatir o retrasar
la apariciĂłn de estas enfermedades. En este sentido, la
prevenciĂłn tambiĂ©n es clave para evitar las graves consecuencias, relacionadas con la diabetes y el sĂndrome
metabĂłlico, que pueden afectar a la calidad de vida de
la población.A high caloric intake in today’s nutrition and a
sedentary lifestyle are the main causes of the notable
increase in obesity in our society. In turn, this results in
an increase in associated pathologies, such as metabolic syndrome and diabetes type 2. In the present work
we review most recent studies and programs, which are
significant due to their sample size and geographical
diversity. It clearly shows that changes in alimentation
and lifestyles are an effective instrument for combatting
or delaying the onset of these diseases. In this sense,
prevention is also key to avoiding serious consequences related to diabetes and metabolic syndrome, which
can affect the life of the population
A 500-year tale of co-evolution, adaptation, and virulence: Helicobacter pylori in the Americas
Helicobacter pylori is a common component of the human stomach microbiota, possibly dating back to the speciation of Homo sapiens. A history of pathogen evolution in allopatry has led to the development of genetically distinct H. pylori subpopulations, associated with different human populations, and more recent admixture among H. pylori subpopulations can provide information about human migrations. However, little is known about the degree to which some H. pylori genes are conserved in the face of admixture, potentially indicating host adaptation, or how virulence genes spread among different populations. We analyzed H. pylori genomes from 14 countries in the Americas, strains from the Iberian Peninsula, and public genomes from Europe, Africa, and Asia, to investigate how admixture varies across different regions and gene families. Whole-genome analyses of 723 H. pylori strains from around the world showed evidence of frequent admixture in the American strains with a complex mosaic of contributions from H. pylori populations originating in the Americas as well as other continents. Despite the complex admixture, distinctive genomic fingerprints were identified for each region, revealing novel American H. pylori subpopulations. A pan-genome Fst analysis showed that variation in virulence genes had the strongest fixation in America, compared with non-American populations, and that much of the variation constituted non-synonymous substitutions in functional domains. Network analyses suggest that these virulence genes have followed unique evolutionary paths in the American populations, spreading into different genetic backgrounds, potentially contributing to the high risk of gastric cancer in the region.Fil: Muñoz Ramirez, Zilia Y.. INSTITUTO POLITÉCNICO NACIONAL (IPN);Fil: Pascoe, Ben. University of Bath; Reino UnidoFil: Mendez Tenorio, Alfonso. INSTITUTO POLITÉCNICO NACIONAL (IPN);Fil: Mourkas, Evangelos. University of Bath; Reino UnidoFil: Sandoval Motta, Santiago. Consejo Nacional de Ciencia y TecnologĂa; MĂ©xicoFil: Perez Perez, Guillermo. New York University Langone Medical Center; Estados UnidosFil: Morgan, Douglas R.. University of Alabama at Birmingahm; Estados UnidosFil: Dominguez, Ricardo Leonel. Western Honduras Gastric Cancer Prevention Initiative Hospital de Occidente Santa Rosa de Copan; HondurasFil: Ortiz Princz, Diana. No especifĂca;Fil: Cavazza, Maria Eugenia. No especifĂca;Fil: Rocha, Gifone. Universidade Federal de Minas Gerais; BrasilFil: Queiroz, Dulcienne. Universidade Federal de Minas Gerais; BrasilFil: Catalano, Mariana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en MicrobiologĂa y ParasitologĂa MĂ©dica; ArgentinaFil: Zerbetto de Palma, Gerardo Gabriel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Houssay. Instituto de QuĂmica y FĂsico-QuĂmica BiolĂłgicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Instituto de QuĂmica y FĂsico-QuĂmica BiolĂłgicas; ArgentinaFil: Goldman, Cinthia Gabriela. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica; ArgentinaFil: Venegas, Alejandro. Universidad Diego Portales; ChileFil: Alarcon, Teresa. Universidad AutĂłnoma de Madrid; EspañaFil: Oleastro, Monica. Universidade Nova de Lisboa; PortugalFil: Vale, Filipa F.. Universidade Nova de Lisboa; PortugalFil: Goodman, Karen J.. University of Alberta; CanadáFil: Torres, Roberto C.. Instituto Mexicano del Seguro Social; MĂ©xicoFil: Berthenet, Elvire. Swansea University Medical School; Reino UnidoFil: Hitchings, Matthew D.. Swansea University Medical School; Reino UnidoFil: Blaser, Martin J.. Rutgers University; Estados UnidosFil: Sheppard, Samuel K.. University of Bath; Reino UnidoFil: Thorell, Kaisa. University of Gothenburg; SueciaFil: Torres, Javier. Instituto Mexicano del Seguro Social; MĂ©xic
Updating the Food-Based Dietary Guidelines for the Spanish Population: The Spanish Society of Community Nutrition (SENC) Proposal
Diet-related risk factors and physical inactivity are among the leading risk factors for disability and are responsible for a large proportion of the burden of chronic non-communicable diseases. Food-based dietary guidelines (FBDGs) are useful tools for nutrition policies and public health strategies to promote healthier eating and physical activity. In this paper, we discuss the process followed in developing the dietary guidelines for the Spanish population by the Spanish Society of Community Nutrition (SENC) and further explain the collaboration with primary healthcare practitioners as presented in the context of the NUTRIMAD 2018 international congress of SENC. From a health in all policies approach, SENC convened a group of experts in nutrition and public health to review the evidence on diet-health, nutrient intake and food consumption in the Spanish population, as well as food preparation, determinants and impact of diet on environmental sustainability. The collaborative group drafted the document and designed the graphic icon, which was then subject to a consultation process, discussion, and qualitative evaluation. Next, a collaborative group was established to plan a dissemination strategy, involving delegates from all the primary healthcare scientific societies in Spain. A product of this collaboration was the release of an attractive, easy-to-understand publication
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