Cultivating Comadrerismo for Collective Liberation

In this paper, we draw from our positionality, respective roles on campus, and experience with developing the UndocuScholars Research Methods class. We argue that despite learning to navigate during a pandemic and dealing with the coexistence of grief and joy, transformation in the academy is possible when seeds are planted through building community, vulnerability, and the creation of an equitable and student-centered curriculum. At the same time, transformation in the academy occurs among faculty and staff through the development of comadrerismo, which is a bond that extends beyond collegiality, as it seeks to foster a sisterhood that honors, supports, and validates people’s journeys, roles, and goals in life. In the end, we all benefit from the harvest by reimagining spaces as locations where we can experience healing, transformation, and eventually, collective liberation. It is within our line of work that we can envision, change, and benefit from altering the institutional practices that move us to radically shift from individualistic to communal joy

Chronic Obstructive Pulmonary Disease in Latin America

The PLATINO and PREPOCOL population-based studies documented the prevalence of chronic obstructive pulmonary disease (COPD) in several Latin American (Mexico City, Sao Paulo, Montevideo, Santiago and Caracas) and Colombian (Medellin, Bogota, Barranquilla, Bucaramanga and Cali) cities. COPD ranged between 6.2 and 19.6% in individuals ≥40 years of age, with substantial rates of underdiagnosis (up to 89%) but also overdiagnosis, mostly due to the lack of spirometric confirmation. The main risk factor was tobacco smoking, but male gender and age were also associated with COPD. COPD in never smokers represented about one third of the cases and was associated with previous history of tuberculosis or a diagnosis of asthma. COPD associated with biomass smoke exposure was a common clinical phenotype in Latin America, found as a risk factor in PREPOCOL and other observational studies in the region. Smoking has been decreasing in Latin America and efforts have been made to implement cleaner biomass stoves. Unfortunately, treatment of COPD in Latin America remains highly variable with low rates of smoking cessation counselling, low use of inhaled bronchodilators and influenza vaccination. A primary-care approach to COPD, particularly in the form of integrated programs is lacking but would be critical to improving rates of diagnosis and treatment of COPD

Análisis funcional de efectores candidatos de Podosphaera xanthii

Los oídios son patógenos biotrofos obligados que requieren células vivas para su desarrollo, por lo que deben eludir o inhibir las respuestas de defensa de la planta mediante la secreción de efectores para completar su ciclo de vida. El haustorio, estructura del hongo especializada en la toma de nutrientes, es también la vía de intercambio de factores con las células huésped. Hasta la fecha, son muy numerosos los efectores identificados en diversos hongos fitopatógenos, sin embargo, los efectores de los oídios están poco caracterizados todavía. En este trabajo hemos desarrollado un método para la identificación y el análisis de efectores candidatos de Podosphaera xanthii (ECP), el principal agente causal del oídio de las cucurbitáceas, mediante silenciamiento génico inducido por hospedador (HIGS) y la sobrexpresión de estos efectores en cotiledones de melón, utilizando para ello Agrobacterium tumefaciens. El silenciamiento de algunos de los ECP analizados provocó la acumulación en las células de la planta de compuestos relacionados con las respuestas de defensa como peróxido de hidrógeno (H2O2) y calosa, lo que sugiere un importante papel en el establecimiento de la infección. En concreto, ECPEc2 parece interferir específicamente con la formación de la papila, primera barrera de defensa de la planta que impide o ralentiza la penetración de la célula vegetal. En el caso de ECP5191, su silenciamiento se traduce un aumento del número de células que acumulaban H2O2 y calosa, así como una disminución en el número de puntos de penetración del hongo, observándose todo lo contrario cuando se sobrexpresa dicho efector. Además, la fusión traduccional CSEP5191-GFP ha permitido localizar este efector en los puntos de penetración y vesículas del haustorio del hongo.Este trabajo ha sido financiado por ayudas del Plan Nacional de I+D+I del anterior Ministerio de Ciencia e Innovación (AGL2010-21848-CO2-01), cofinanciado con fondos FEDER (UE)y una ayuda del Plan Propio de Investigación de la Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Pregnenolone and pregnenolone sulfate metabolism by human fetal testes in vitro

Homogenates of testes from human fetuses of 12-16 weeks gestation were incubated in vitro with pregnenolone-4-14C and pregnenolone-7-3H-sulfate. Dehydroepiandrosterone sulfate and pregnenediol sulfate, each bearing the tritium label only, were identified in the conjugated fraction. Progesterone, 17[alpha]-hydroxyprogesterone, 17[alpha]-hydroxypregnenolone, dehydroepiandrosterone, androstenedione and testosterone, each bearing both a tritium and 14C-label, were identified in the organic fraction. In a similar incubation, with pregnenolone-7-3H-sulfate-35S as substrate, the direct conversion to 17[alpha]-hydroxypregnenolone sulfate was demonstrated. The presence of slight sulfatase activity was also noted. The direct metabolism of steroid sulfates and the presence of sulfatase activity in this fetal tissue and the possible significance of these findings in the developing male fetus are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32735/1/0000104.pd

Identificação de variáveis de relevância no índice de contusões associadas ao transporte de gado de corte

Este trabalho objetiva contribuir para a melhoria das condições de bemestar animal durante o processo de transporte da propriedade para o frigorífico, bem como diminuir as perdas financeiras relacionadas às contusões desenvolvidas e ao estresse animal durante este processo. A metodologia usada busca identificar as variáveis relacionadas ao transporte de gado de corte que tenham maior impacto no índice de contusões associadas ao processo. Os dados foram coletados durante um período de quatro meses em um frigorífico da região sul do Brasil. As conclusões do trabalho apontam que existem questões sobre organização das cargas que precisam ser levadas em consideração pelas empresas de transporte.Sociedad Argentina de Informática e Investigación Operativ

Identificação de variáveis de relevância no índice de contusões associadas ao transporte de gado de corte

Este trabalho objetiva contribuir para a melhoria das condições de bemestar animal durante o processo de transporte da propriedade para o frigorífico, bem como diminuir as perdas financeiras relacionadas às contusões desenvolvidas e ao estresse animal durante este processo. A metodologia usada busca identificar as variáveis relacionadas ao transporte de gado de corte que tenham maior impacto no índice de contusões associadas ao processo. Os dados foram coletados durante um período de quatro meses em um frigorífico da região sul do Brasil. As conclusões do trabalho apontam que existem questões sobre organização das cargas que precisam ser levadas em consideração pelas empresas de transporte.Sociedad Argentina de Informática e Investigación Operativ

Identificação de variáveis de relevância no índice de contusões associadas ao transporte de gado de corte

Este trabalho objetiva contribuir para a melhoria das condições de bemestar animal durante o processo de transporte da propriedade para o frigorífico, bem como diminuir as perdas financeiras relacionadas às contusões desenvolvidas e ao estresse animal durante este processo. A metodologia usada busca identificar as variáveis relacionadas ao transporte de gado de corte que tenham maior impacto no índice de contusões associadas ao processo. Os dados foram coletados durante um período de quatro meses em um frigorífico da região sul do Brasil. As conclusões do trabalho apontam que existem questões sobre organização das cargas que precisam ser levadas em consideração pelas empresas de transporte.Sociedad Argentina de Informática e Investigación Operativ

Beyond the CNS: The many peripheral roles of APOE

Apolipoprotein E (APOE) is a multifunctional protein synthesized and secreted by multiple mammalian tissues. Although hepatocytes contribute about 75% of the peripheral pool, APOE can also be expressed in adipose tissue, the kidney, and the adrenal glands, among other tissues. High levels of APOE production also occur in the brain, where it is primarily synthesized by glia, and peripheral and brain APOE pools are thought to be distinct. In humans, APOE is polymorphic, with three major alleles (e2, e3, and e4). These allelic forms dramatically alter APOE structure and function. Historically, the vast majority of research on APOE has centered on the important role it plays in modulating risk for cardiovascular disease and Alzheimer's disease. However, the established effects of this pleiotropic protein extend well beyond these two critical health challenges, with a demonstrated roles for APOE across a wide spectrum of biological conditions, including adipose tissue function and obesity, metabolic syndrome and diabetes, fertility and longevity, and immune function. While the spectrum of biological systems in which APOE plays a role seems implausibly wide at first glance, there are some potential unifying mechanisms that could tie these seemingly disparate disorders together. In the current review, we aim to concisely summarize a wide breadth of APOE-associated pathologies and to analyze the influence of APOE in the development of several distinct disorders in order to provide insight into potential shared mechanisms implied in these various pathophysiological processes