A Study of the Philosophical Significance of the Teachings in the Kaṭhopaniṣad

Upaniṣad literature can be called the most important group of Vedic literary works in Eastern philosophy, and one of its most important Upaniṣads called Kaṭhopaniṣad, is an Upaniṣad book of outstanding value literary and philosophically. This work, which belongs to the Kriṣna Yajurveda, discusses the facts in the form of a dialogue between Nachiketas and Yama. The primary purpose of this research is to investigate to what extent the philosophical importance of the teachings in the Kaṭhopaniṣad, and to what extent the teachings contained in the Kaṭhopaniṣad are similar to other Indian philosophical teachings and whether it covers all the basic study areas of the philosophy. It is expected to conduct a comprehensive study in this work. As this research is mainly used the book research method, it is primarily based on the study of primary and secondary sources. In addition to this, interviews with experts, journal articles and internet sources are used to gather information. Several philosophical methodologies are used to analyze the research problems including descriptive analysis, critical method, comparative method and analytical method. According to the analysis of this research, the final conclusion can be implied that there can be many similarities between Kaṭhopaniṣad and Buddhism not only in terms of the ideas of the teachings of it but also in the way of expression in its technical terms. In addition to this, another point in the conclusion is that philosophically Kaṭhopaniṣad is an extremely important literary work that includes a certain kind of metaphysics, cosmology, epistemology, psychology as well as ethics.   DOI: http://doi.org/10.31357/fhss/vjhss.v09i01.1

Free vibration of a three-layered sandwich beam using the dynamic stiffness method and experiment

In this paper, an accurate dynamic stiffness model for a three-layered sandwich beam of unequal thicknesses is developed and subsequently used to investigate its free vibration characteristics. Each layer of the beam is idealised by the Timoshenko beam theory and the combined system is reduced to a tenth-order system using symbolic computation. An exact dynamic stiffness matrix is then developed by relating amplitudes of harmonically varying loads to those of the responses. The resulting dynamic stiffness matrix is used with particular reference to the Wittrick-Williams algorithm to carry out the free vibration analysis of a few illustrative examples. The accuracy of the theory is confirmed both by published literature and by experiment. The paper closes with some concluding remarks. (c) 2007 Elsevier Ltd. All rights reserved

Synthesis, Characterization and Remarkable Anticancer Activity of Rhenium Complexes Containing Biphenyl Appended NNN Donor Sulfonamide Ligands

Neutral and cationic rhenium complexes provide both hydrophilic as well as hydrophobic properties due to the robustness of the tridentate ligand system of biphenyl appended dipicolylamine (N(SO2bip)dpa) and diethylenetriamine (N(SO2bip)dienH) coordinated to the [Re(CO)3]+ core, hold immense potential for the development of metal based anticancer drugs. This was achieved by the synthesis of two ligands (L1: N(SO2bip)dpa and L2: (N(SO2bip)dienH) and their corresponding Re complexes (C1: [Re(CO)3(N(SO2bip)dpa)]PF6 and C2: [Re(CO)3(N(SO2bip)dien)] in good yield and high purity. All four compounds were characterized by 1H NMR, UV-Vis, FTIR spectroscopies and L1, also by single crystal X-ray diffraction. The methylene protons observed as a singlet at (4.59 ppm) in a 1H NMR spectrum of L1 appear as two doublets (5.66 and 4.65 ppm) in the spectrum of C1. The appearance of NH signals at 3.48, 5.17 and 6.69 ppm in the 1H NMR spectrum of C2 confirm the coordination of L2 with Re. The stretching vibration frequencies depicted by the S-N bond at 923 cm-1 for L1 appear towards lower frequencies (821 cm-1) in an FTIR spectrum of C1, while the S-N bond at 943 cm-1 for L2 appears towards higher frequencies (968 cm-1) in C2. In silico assessment of drug likeliness revealed zero violations demonstrating a high likeliness of the ligands to be successful as drug leads. All four compounds have shown very low IC50 values against non-small cell lung cancer cells (NCI-H292). Therefore, L1, C1, L2 and C2 are promising novel compounds that can be further investigated as potential anticancer agents. Keywords: Rhenium Tricarbonyl, Sulfonamide, Anticancer, Fluorescence

Levels of cancellation for monoids and modules

Levels of cancellativity in commutative monoids M, determined by stable rank values in Z>0 ∪ {∞} for elements of M, are investigated. The behavior of the stable ranks of multiples ka, for k ∈ Z>0 and a ∈ M, is determined. In the case of a refinement monoid M, the possible stable rank values in archimedean components of M are pinned down. Finally, stable rank in monoids built from isomorphism or other equivalence classes of modules over a ring is discussed.The first and sixth authors were partially supported by the Spanish State Research Agency (grant No. PID2020-113047GB-I00/AEI/10.13039/501100011033), by the Comissionat per Universitats i Recerca de la Generalitat de Catalunya (grant No. 2017-SGR-1725) and by the Spanish State Research Agency through the Severo Ochoa and María de Maeztu Program for Centers and Units of Excellence in R&D (CEX2020-001084-M). The third author was partially supported by the Simons Foundation (grant #963435). The third and fourth authors thank the Mathematics Department of the Universitat Autònoma de Barcelona for hospitality during their visits, and the fourth author also thanks the Mathematics Departments of the University of California, Santa Barbara and the Universidad de Cádiz for their hospitality during the early part of this project. The fifth author was partially supported by PAI III grant FQM- 298 of the Junta de Andalucía, by the DGI-MINECO and European Regional Development Fund, jointly, through grant PID2020-113047GB-I00, and by the grant “Operator Theory: an interdisciplinary approach”, reference ProyExcel 00780, a project financed in the 2021 call for Grants for Excellence Projects, under a competitive bidding regime, aimed at entities qualified as Agents of the Andalusian Knowledge System, in the scope of the Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020), Consejería de Universidad, Investigación e Innovación of the Junta de Andalucía

Diagnostic strategies used in primary care

The strategies used by general practitioners in making a diagnosis are being formally recognised; this article is the first in a series that will illustrate their application, and is accompanied by a case study (doi:10.1136/bmj.b1187

Histidine switch controlling pH-dependent protein folding and DNA binding in a transcription factor at the core of synthetic network devices

© 2016 The Royal Society of Chemistry. Therapeutic strategies have been reported that depend on synthetic network devices in which a urate-sensing transcriptional regulator detects pathological levels of urate and triggers production or release of urate oxidase. The transcription factor involved, HucR, is a member of the multiple antibiotic resistance (MarR) protein family. We show that protonation of stacked histidine residues at the pivot point of long helices that form the scaffold of the dimer interface leads to reversible formation of a molten globule state and significantly attenuated DNA binding at physiological temperatures. We also show that binding of urate to symmetrical sites in each protein lobe is communicated via the dimer interface. This is the first demonstration of regulation of a MarR family transcription factor by pH-dependent interconversion between a molten globule and a compact folded state. Our data further suggest that HucR may be utilized in synthetic devices that depend on detection of pH changes

The AzTEC mm-Wavelength Camera

AzTEC is a mm-wavelength bolometric camera utilizing 144 silicon nitride micromesh detectors. Herein we describe the AzTEC instrument architecture and its use as an astronomical instrument. We report on several performance metrics measured during a three month observing campaign at the James Clerk Maxwell Telescope, and conclude with our plans for AzTEC as a facility instrument on the Large Millimeter Telescope.Comment: 13 pages, 15 figures, accepted for publication in Monthly Notice

Apparent finite-size effects in the dynamics of supercooled liquids

Molecular dynamics simulations are performed for a supercooled simple liquid with changing the system size from N=108 to $10^4$ to examine possible finite-size effects. Although almost no systematic deviation is detected in the static pair correlation functions, it is demonstrated that the structural $\alpha$ relaxation in a small system becomes considerably slower than that in larger systems for temperatures below $T_c$ at which the size of the cooperative particle motions becomes comparable to the unit cell length of the small system. The discrepancy increases with decreasing temperature.Comment: 4 pages 5 figure