Charmonium Production at Forward Rapidity in pp, p-Pb and Pb-Pb Collisions, with ALICE

This contribution focuses on latest ALICE results on charmonium forward production in proton-proton (pp), proton-lead (p-Pb) and lead-lead (Pb-Pb) collisions at the TeV scale. In p-Pb and Pb-Pb collisions, measurements are presented in the form of the charmonium nuclear modification factor (the properly normalized ratio of its production cross section in heavy ion collisions to its pp counterpart) as a function of the charmonium rapidity and transverse momentum. These measurements are compared to available theoretical calculations. Possible interpretations of these results in terms of gluon saturation, initial and final state energy loss, color screening and recombination are also discussed.Comment: 6 pages, 11 figures, Conference Proceedings Large Hadron Collider Physics (LHCP) Conference, 201

Women in Resistance: Reporting the impact of IEEEWiEUFRNexhibition at Science and Tech Week at UFRN

In celebration of the 60th anniversary of UFRN, we have proposed an initiative by IEEE WiEUFRNat CIENTEC aiming to highlight the female contribution to the STEM (Science, Technology, Engineering and Maths) degrees at UFRN over the last 60 years. The highlights were made through an exhibition, composed of four parts: I) description of renowned female icons and their contributions to the STEM areas. II) History of female participation in STEM courses at UFRN, through graphs showing the percentage of female students in the courses since its creation. III) #euexisto campaign: display of testimonials videos from current students of STEM courses explaining why they chose the course. IV) Tribute to female Lecturers: display all female lecturersnames that have taught in STEM courses at UFRN. As a result, the group paida tribute to those brilliant women and highlighted their contribution to STEM;acknowledged the current students and teachers of the courses; and helped raising awareness about the need to encourage the participation of women in these courses and in order to build a more diverse environment. Our main goal was raise awareness that the degrees of STEM had consistently less women than man and thus, our feminist group had a very important role to play in increasing those numbers. From the informal feedback we received, we believe our goal was achieved

Sacrifice and Efficiency of the Income Tax Schedule

We investigate the efficiency of equal sacrifice tax schedules in an economywhich primitives are exactly those in Mirrlees (1971): a continuum of individualswith identical preferences defined over consumption and leisure who differ withrespect to their labor market productivity. Using a separable specification forpreferences we derive the minimum equal sacrifice allocation and recover thetax schedule that implements it. The separable specification allows us to usethe methodology developed by Werning (2007b) to check whether the scheduleis efficient, that is, whether there is no alternative tax schedule that raises morerevenue while delivering less utility to no one. We find that inefficiency does notarise for most parametrizations we use to approximate the US economy. For thefew cases for which inefficiency does arise, it does so only for very high levels ofincome and marginal tax rates.

Escroto agudo na criança.

Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Pediatria, Curso de Medicina, Florianópolis, 200

In-medium formation of quarkonium

We confront preliminary RHIC data on J/Psi production in nuclear interactions with expectations which follow in scenarios involving charm quark recombination in a region of color deconfinement. The focus is on transverse momentum and rapidity spectra of the J/Psi, which carry a memory of the spectra of the charm quarks. In such a scenario, one predicts that both spectra will be narrower than those expected without recombination. Preliminary results for the transverse momentum spectra point toward a preference for the recombination picture, while the rapidity spectra do not exhibit any narrowing within present large uncertainties. We present new calculations in the recombination model for the centrality behavior of these signals, which map out the necessary experimental precision required for a definitive test.Comment: Based on invited talk at Strangeness in Quark Matter 2006, UCLA, March 26-31, 2006. Clarifying remarks added in published journal versio

INVESTIGACIÓN Y DESARROLLO TERRITORIAL Dimensiones de la relación entre intereses científicos y demandas locales en el área de influencia de la Universidad Nacional de Luján.

En esta ponencia se manifiesta que el desarrollo territorial es un ámbito apropiado para evaluar el proceso de investigación y producción de conocimientos. Desde el interjuego de variables generales tales como: configuración socioeconómica territorial, intereses y demandas de la sociedad, y políticas de investigación de la Universidad Nacional de Luján (UNLu), se busca caracterizar y dimensionar la relación entre conocimiento construido en los distintos departamentos de la universidad y la resolución de problemáticas locales. Se intenta sentar bases para identificar problemas y reformular políticas de investigación a partir de: a. Configurar la situación socioeconómica territorial del área de influencia de la UNLu. para detectar problemas. b. Identificar los intereses y demandas de los distintos sectores de la sociedad involucrada. c. Inventariar los proyectos de investigación desarrollados en la UNLu. desde 1995. d. Reconocer las ideas que actuaron como mapas de rutas para la definición de las políticas de investigación. e. Visualizar la relación entre intereses de la comunidad e ideas que perfilaron los proyectos de investigación. f. Establecer el nivel de correspondencia con el plan estratégico nacional de mediano plazo en ciencia, tecnología e innovación y los indicadores de ciencia y tecnología interamericana / iberoamericana

PGC-1α: a target for neurodegenerative disorders

Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2021, Universidade de Lisboa, Faculdade de Farmácia.Com o aumento da esperança média de vida, também o impacto social e económico associado a problemas de saúde tem vindo a crescer. As doenças neurodegenerativas tendem a manifestar-se com a idade, principalmente devido à sua longa fase assintomática, durante a qual a doença já está em progressão, portanto a sua incidência tem aumentado e continuará a aumentar em todo o mundo, acompanhando a tendência de envelhecimento e crescimento da população. Entretanto, os tratamentos disponíveis para a maioria destas patologias apenas aliviam os sintomas já numa fase avançada, não existindo ainda disponíveis opções que alterem ou impeçam o seu curso natural. Ora, esta falta de alternativas farmacológicas é consequência da incerteza existente em relação aos mecanismos fisiopatológicos que originam estas doenças e à enorme variabilidade registada na população afetada. No entanto, vários estudos evidenciaram que a disfunção mitocondrial e o stress oxidativo desempenham um papel importante na patogénese de doenças como a doença de Alzheimer, doença de Parkinson e doença de Huntington, por exemplo. Tendo em conta a grande necessidade de aporte energético do tecido cerebral, tal não é inesperado. O peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) é visto como um importante co-regulador da função mitocondrial desde a sua descoberta, há mais de 20 anos, e a sua hipotética relação com as doenças neurodegenerativas e expectável potencial terapêutico têm sido considerados e avaliados desde o início. Na verdade, vários modelos animais sem PGC-1α têm, desde então, revelado a presença de anomalias comportamentais e neurodegeneração, o que parece provar esta ligação. Assim, regular seletivamente a ação do PGC-1α (para evitar efeitos prejudiciais e indesejados noutros tecidos onde este também é expresso) poderá ser uma forma interessante e específica de mitigar a disfunção mitocondrial e o stress oxidativo. Contudo, ter como alvo um co-regulador da transcrição constitui um desafio a vários níveis, mas também apresenta diversas possibilidades, especialmente considerando os avanços científicos e tecnológicos recentes e futuros. Deste modo, a hipótese de usar o PGC-1α como um alvo terapêutico altamente específico para o tratamento de doenças como as neurodegenerativas não pode ser excluída e aguarda novos desenvolvimentos.With increased life expectancy comes a greater disease burden that accounts for a gigantic social and economic impact. Neurodegenerative disorders (NDDs) are among the diseases that tend to manifest with age, especially given their long asymptomatic phase during which the disease is already progressing and leading to neurologic alterations. So, their incidence has been rising and will continue to do so worldwide, accompanying the population growth and ageing tendency. In the meantime, the available treatments for most of them focus on symptomatic relief, with no disease-modifying options available. This lack of pharmacological alternatives is a consequence of poor established knowledge regarding the pathophysiological mechanisms of these disorders. However, several studies have reported that mitochondrial dysfunction and oxidative stress play major roles in the pathogenesis of diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD), for example. This comes as no surprise given the high energy demands of the brain. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) has emerged as a master co-regulator of mitochondrial function since its discovery more than 20 years ago, so its putative connection to NDDs and hypothetical therapeutic potential was considered and assessed from the start. In fact, several animal models lacking PGC-1α have since then shown behavioural abnormalities and neurodegeneration, which might prove this connection. Thus, selectively targeting PGC-1α (in order to avoid deleterious and unwanted effects in other tissues where it is also expressed) could be an appealing and fine-tuned way of mitigating mitochondrial dysfunction and related oxidative stress. However, targeting a transcriptional co-regulator comes with significant challenges but also with a vast number of opportunities, especially considering the recent scientific and technological breakthroughs. Thus, the prospect of using PGC-1α as a highly specific therapeutic target for the treatment of NDDs and other diseases cannot be ruled out and awaits further developments