Completely reducible hypersurfaces in a pencil

We study completely reducible fibers of pencils of hypersurfaces on $\mathbb P^n$ and associated codimension one foliations of $\mathbb P^n$. Using methods from theory of foliations we obtain certain upper bounds for the number of these fibers as functions only of $n$. Equivalently this gives upper bounds for the dimensions of resonance varieties of hyperplane arrangements. We obtain similar bounds for the dimensions of the characteristic varieties of the arrangement complements.Comment: 15 pages, 2 figure

Social capital and factors associated with the caries experience in adults : a population-based study in Brazil

The objective of this study was to investigate the experience of caries related to social capital and associated factors in adults in large-scale population-based study. A Cross-sectional study was performed in 163 municipalities in the State of São Paulo, Brazil (SBSP-2015). 17,560 people were evaluated, of which 6051 were adults aged 35-44 years. Hierarchical logistic regression analysis was proposed. Outcome variables (decayed teeth, missing teeth and DMFT) and independent variables were included in the model, considering the distal (income and schooling); intermediate (social capital) and proximal levels (sex and ethnicity). Results showed that income up to 1,500 reais - US$ 367.6 in 11/11/2019 - (OR = 1.91;1.75-2.08), schooling up to 8 years (OR = 1.32;1.12-1.56) and non-white ethnicity (OR = 1.54;1.35-1.76) were more likely to have decayed teeth. Income up to 1500 reais (OR = 1.29;1.15-1.44), schooling up to 8 years (OR = 2.13;1.90-2.38), low social capital (OR = 1.84;1.65-2.04), medium social capital (OR = 1.15;1.01-1.30) and females were more likely to have lost teeth (OR = 1.13;1.03-1.23). Schooling up to 8 years (OR = 1.51;1.35-1.69), low social capital (OR = 1.25; 1.14-1.37) and female (OR = 1.40,1.19-1.53) were associated with DMFT. It was concluded that sociodemographic factors and low social capital were associated with the experience of caries, which should be taken into account in the formulation of public policies3

Lymphocyte ceruloplasmin and Behçet's disease

Behçet's disease (BD) is a rare chronic inflammatory disorder of unknown aetiology. However, it has been postulated that a dysregulation of the prooxidant/antioxidant balance may be important to its pathogenesis. Ceruloplasmin (CP) is an acute phase protein expressed at the surface of peripheral blood lymphocytes (PBL) with antioxidant properties and with a relevant role in iron (Fe) metabolism

Malocclusion and dental appearance in underprivileged brazilian adolescents

Satisfaction with dental aesthetics is a subjective indicator used in epidemiological studies and is related to health behaviours. Little is known about the factors that influence this indicator, particularly among adolescents who live in a situation of social vulnerability. The aim of this study was to investigate the relationship between malocclusion and dental appearance in underprivileged Brazilian adolescents. This analytical cross-sectional study was conducted in Piracicaba, Brazil, and evaluated 884 adolescents from 13 to 19 years of age. The dependent variable was satisfaction with dental appearance, and the independent variables were classified as individual (components of the Dental Aesthetic Index - DAI, sex and age) and contextual (social exclusion index). For statistical analysis, multilevel regression models were estimated. The individual variables were considered Level 1, and the contextual variable was considered Level 2, with a level of significance of 5%. The mean age of the adolescents was 15.3 years. Female adolescents more frequently affirmed that they were satisfied with their dental appearance than did male individuals. There was an increase in dissatisfaction with oral health with the increase in anterior maxillary overjet, midline diastema, larger anterior irregularity in the maxilla, larger anterior irregularity in the mandible, anterior open bite and antero-posterior molar relation. Satisfaction with dental appearance was associated with individual factors such as sex and DAI components33CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ141654/2013-

Anadenanthera colubrina vell brenan : anti-candida and antibiofilm activities, toxicity and therapeutical action

We evaluated the antifungal and antibiofilm potential of the hydroalcoholic extract of bark from Anadenanthera colubrina (vell.) Brenan, known as Angico, against Candida spp. Antifungal activity was evaluated using the microdilution technique through the Minimum Inhibitory and Fungicide Concentrations (MIC and MFC). The antibiofilm potential was tested in mature biofilms formed by Candida species and analyzed through the counting of CFU/mL and scanning electron micrograph (SEM). In vivo toxicity and therapeutic action was evaluated in the Galleria mellonella model. The treatment with the extract, in low doses, was able to reduce the growth of planktonic cells of Candida species. MIC values range between 19.5 and 39 µg/mL and MFC values range between 79 and 625 µg/mL. In addition was able to reduce the number of CFU/mL in biofilms and to cause structural alteration and cellular destruction, observed via SEM. A. colubrina showed low toxicity in the in vivo assay, having not affected the viability of the larvae at doses below 100mg/kg and high potential in the treatment of C. albicans infection. Considering its high antifungal potential, its low toxicity and potential to treatment of infections in in vivo model, A. colubrina extract is a strong candidate for development of a new agent for the treatment of oral candidiasis33CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ552562/2011-

Correlation Between Audiometric Data And The 35delg Mutation In Ten Patients

Mutations in the connexin 26 gene seem to be extremely common in non-syndromic hereditary deafness genesis, especially the 35delG, but there are still only a few studies that describe the audiometric characteristics of patients with these mutations. Aim: to analyze the audiometric characteristics of patients with mutations in the connexin 26 gene in order to outline genotype-phenotype correlation. Materials and Methods: Tonal audiometries of 33 index cases of non-syndromic sensorineural hearing loss were evaluated and eight affected relatives. Specific molecular tests were carried out to analyze mutations in the connexin 26 gene. Experiment Design: Retrospective, cross-sectional study. Results: A 27.3% prevalence of mutation 35delG was found in the index cases and 12.5% among the relatives affected. In relation to hearing loss degree, 41.5% of the patients were found with profound hearing loss, 39% with severe HL and 19.5% with moderate HL with homozygote and heterozygote patients for the 35delG predominating in the severe-moderate hearing losses. Conclusion: Our results suggest that the audiometric data associated with the molecular diagnose of hearing loss helped us to outline a genotype-phenotype correlation in ten patients with 35delG mutation. However, it is still necessary to run multicentric studies to verify the real phenotypic expression in the Brazilian population, as far as the 35delG mutation is concerned. © Revista Brasileira de Otorrinolaringologia. All Rights reserved.736777783Morton, N.E., Genetic epidemiology of hearing impairment (1991) Ann N Y Acad Sci, 630, pp. 16-31Mustafa, T., Arnos, K.S., Pandya, A., Advances in hereditary deafness (2001) Lancet, 358, pp. 1082-1090Skvorak Giersch, A.B., Morton, C.C., Genetic causes of nonsyndromic hearing loss (1999) Curr Opin Pediatr, 11 (6), pp. 551-557Petit, C., Genes responsible for human hereditary deafness: Symphony of a thousand (1996) Nature Genet, 14, pp. 385-391Van Camp, G., Willems, P.J., Smith, R.J.H., Nonsyndromic hearing impairment: Unparalleled heterogeneity (1997) Am J Hum Genet, 60, pp. 758-764Kelsell, D.P., Dunlop, J., Stevens, H.P., Lench, N.J., Liang, J.N., Parry, G., Mueller, R.F., Leigh, I.M., Connexin 26 mutations in hereditary non-syndromic sensorineural deafness (1997) Nature, 387, pp. 80-83Kelley, P.M., Harris, D.J., Comer, B.C., Askew, J.W., Fowler, T., Smith, S.D., Kimberling, W.J., Novel mutations in the connexin 26 gene (GJB2) that cause autossomal recessive (DFNB1) hearing loss (1998) Am J Hum Genet, 62, pp. 792-799Scott, D.A., Kraft, M.L., Carmi, R., Ramesh, A., Elbedour, K., Yari, Y., Srisailapathy, C.R.S., Identification of mutation on the connexin 26 gene that cause autossomal recessive nonsyndromic hearing loss (1998) Hum Mutat, 11, pp. 387-394Gabriel H, Kupsch P, Sudendey Jr, Winterhager E, Jahnke K, et al. Mutations in the connexin 26/GJB2 gene are the most common event in non-syndromic hearing loss among the German population. Hum Mutat 2001;17:521-2Van Camp G, Smith RJH. Na Hereditary Hearing Loss Homepage [Site na Internet]. Disponível em: http://webhost.ua.ac.be/hhh/. Acessado em 2006Zelante, L., Gasparini, P., Estivill, X., Melchionda, S., D'Agruma, L., Govea, N., Mila, M., Della Monica, M., Connexin 26 mutations associated with the most common form of non-syndromic neurosensory autossomal recessive deafness (DFNB1) in Mediterraneans (1997) Hum Molec Genet, 6, pp. 1605-1609Estivill, X., Fortina, P., Surrey, S., Rabionet, R., Melchionda, S., D'Agruma, L., Mansfield, E., Rappaport, E., Connexin 26 mutations in sporadic and inherited sensorineural deafness (1998) Lancet, 351, pp. 394-398Antoniadi, T., Gronskov, K., Sand, A., Pampanos, A., Brondum-Nielsen, K., Petersen, M.B., Mutation analysis of the GJB2 (connexin 26) gene by DGGE in greek patients with sensorineural deafness (2000) Hum Mutat, 16, pp. 7-12Oliveira, C.A., Maciel-Guerra, A.T., Sartorato, E.L., Deafness resulting from mutations in the GJB2 (connexin 26) gene on Brazilian patients (2002) Clin Genet, 61, pp. 354-358Kammen-Jolly, K., Ichiki, H., Scholtz, A.W., Gsenger, M., Kreczy, A., Schrott-Fischer, A., Connexin 26 in human fetal development of the inner ear (2001) Hear Res, 160 (1-2), pp. 15-21Denoyelle, F., Marlin, S., Weil, D., Moatti, L., Chauvin, P., Garabedian, E.N., Petit, C., Clinical features of the prevalent form of childhood deafness, DFNB1, due to a connexin 26 gene defect: Implications for genetic counselling (1999) Lancet, 17 (9161), pp. 1298-1303Cryns, K., Orzan, E., Murgia, A., Huygen, P.L.M., Moreno, F., del Castilo, I., A genotype-phenotype correlation for GJB2 (connexin 26) deafness) (2004) J Med Genet, 41, pp. 147-154(1991) Report of the informal working group on prevention of deafness and hearing impairment programme planning, , World Health Organization, Geneva: WHO, 22pAntoniadi, T., Gronskov, K., Sand, A., Pampanos, A., Brondum-Nielsen, K., Petersen, M.B., Mutation analysis of the GJB2 (connexin 26) gene by DGGE in Greek patients with sensorineural deafness (2000) Hum Mutat, 16, pp. 7-12del Castillo, I., Villamar, M., Moreno-Pelayo, M.A., del Castillo, F.J., Alvarez, A., Telleria, D., A deletion involving the connexin 30 gene in nonsyndromic hearing impairment (2002) N Engl J Med, 346, pp. 243-249Kelley, P.M., Harris, D.J., Comer, B.C., Askew, J.W., Fowler, T., Smith, S.D., Kimberling, W.J., Novel mutations in the connexin 26 gene (GJB2) that cause autossomal recessive (DFNB1) hearing loss (1998) Am J Hum Genet, 62, pp. 792-799Sobe, T., Vreugde, S., Shahin, H., Berlin, M., Davis, N., The prevalence and expression of inherited connexin 26 mutations associated with non-syndromic hearing loss in the Israeli population (2000) Hum Genet, 106, pp. 50-57Wilcox, S.A., Saunders, K., Osborn, A.H., Arnold, A., Wunderlich, J., High frequency hearing loss correlated with mutations in the GJB2 gene (2000) Hum Genet, 106, pp. 399-405del Castillo, I., Villamar, M., Moreno-Pelayo, M.A., del Castillo, F.J., Alvarez, A., Telleria, D., A deletion involving the connexin 30 gene in nonsyndromic hearing impairment (2002) N Engl J Med, 346, pp. 243-249Frei, K., Szuhai, K., Lucas, T., Weipoltshammer, K., Schofer, C., Ramsebner, R., Connexin 26 mutations in cases of sensorineural deafness in eastern Austria (2002) Eur J Hum Genet, 10, pp. 427-432Pampanos, A., Economides, J., Iliadou, V., Neou, P., Leotsakos, P., Voyiatzis, Prevalence of GJB2 mutations in prelingual deafness in the Greek population (2002) Int J Pediatr Otorhinolaryngol, 65, pp. 101-108Gasparini, P., Estivill, X., Volpini, V., Totaro, A., Castellvi-Bel, S., Linkage of DFNB1 to non-syndromic neurosensory autosomal-recessive deafness in Mediterranean families (1997) Eur J Hum Genet, 5, pp. 83-88Estivill, X., Fortina, P., Surrey, S., Rabionet, R., Melchionda, S., D'Agruma, L., Mansfield, E., Rappaport, E., Connexin 26 mutations in sporadic and inherited sensorineural deafness (1998) Lancet, 351, pp. 394-398Kenna, M.A., Wu, B.-L., Cotanche, D.A., Korf, B.R., Rehm, H.L., Connexin 26 studies in patientes with sensorineural hearing loss (2001) Arch Otolaryngol Head Neck Surg, 127, pp. 1037-1042Simsek, M., Al-Wardy, N., Al-Khayat, A., Shanmugakonar, M., Al-Bulushi, T., Al-Khabory, M., Absence of deafness associated connexin 26 (GJB2) gene mutations in the Omani population (2001) Hum Mutat, 18, pp. 545-546Nance, W.E., The genetics of deafness (2003) Ment Retard Disabil Res Rev, 9, pp. 109-119del Castillo, I., Moreno-Pelayo, M.A., del Castillo, F.J., Brownstein, Z., Marlin, S., Adina, Q., Prevalence and Evolutionary Origins of the del(GJB6-D13S1830) Mutation in the DFNB1 Locus in Hearing Impaired Subjects: A Multicenter Study (2003) Am J Hum Genet, 73, pp. 1452-1458Piatto, V.B., Oliveira, C.A., Alexandrino, F., Pimpinati, C.J., Sartorato, E.L., Perspectivas para triagem auditiva genética: Rastreamento da mutação 35delG em neonatos. (2005) J Pediatr, 81, pp. 139-142Sartorato, E.L., Gottardi, E., Oliveira, C.A., Magna, L.A., Annichio-Bizzacchi, J.M., Seixas, C.A., Maciel-Guerra, A.T., Determination of the frequency of the 35delG in Brazilian neonates (2000) Clin Genet, 58, pp. 339-340Oliveira, C.A., Alexandrino, F., Abe-Sandes, K., Silva Jr, W.A., Maciel-Guerra, A.T., Magna, L.A., Sartorato, E.L., Frequency of 35delG in the GJB2 gene in samples of Caucasians, Asians and African Brazilians (2004) Hum Biol, 76, pp. 313-316Pandya, A., Arnos, K.S., Xia, X.J., Welch, K.O., Blanton, S.H., Friedman, T.B., Frequency and distribution of GJB2 (connexin 26) and GJB6 (connexin 30) mutations in a large North American repository of deaf probands (2003) Genet Med, 5, pp. 295-303Stevenson, V.A., Ito, M., Milunsky, J.M., Connexin-30 deletion analysis in connexin-26 heterozygotes (2003) Genet Test, 7, pp. 151-154Cohn, E.S., Kelley, P.M., Fowler, T.W., Gorga, M.P., Lefkowitz, Clinical studies of families with hearing loss attributable to mutations in the connexin 26 gene (GJB2/DFNB1) (1999) Pediatrics, 103, pp. 546-550Murgia, A., Orzan, E., Polli, R., Martella, M., Vinazi, C., Leonardi, E., Arslan, E., Zacchello, F., Cx26 deafness: Mutation analysis and clinical variability (1999) J Med Genet, 36, pp. 829-832Marlin, S., Garabedian, E.-N., Roger, G., Moatti, L., Matha, N., Lewin, P., Petit, C., Denoyelle, F., Connexin 26 gene mutations in congenitally deaf children (2001) Arch Otolaryngol Head Neck Surg, 127, pp. 927-933Rabionet, R., Zelante, L., Lopez-Bigas, N., DAgruma, L., Melchionda, S., Restagno, G., Molecular basis of childhood deafness resulting from mutations in the GJB2 (connexin 26) gene (2000) Hum Genet, 106, pp. 40-44Cohn, E.S., Kelley, P.M., Clinical phenotype and mutations in connexin 26 (DFNB1/GJB2), the most commom cause of childhood hearing loss (1999) Am J Med Genet, 89, pp. 130-136Denoyelle, F., Marlin, S., Weil, D., Moatti, L., Chauvin, P., Garabedian, E.N., Petit, C., Clinical features of the prevalent form of childhood deafness, DFNB1, due to a connexin 26 gene defect: Implications for genetic counselling (1999) Lancet, 17, pp. 1298-1303Engel-Yeger, B., Zaaroura, S., Zlotogora, J., Shalev, S., Hujeirat, Y., Carrasquilo, M., Barges, S., Pratt, H., The effects of a connexin 26 mutation - 35delG - an oto-acoustic emissions and brainstem evoked potentials: Homozygotes and carriers (2002) Hear Res, 163, pp. 93-100Mustapha, M., Salem, N., Delague, V., Chouery, E., Ghassibeh, M., Rai, M., Loiselet, J., Megarbane, A., Autosomal recessive non-syndromic hearing loss in the Libanese population: Prevalence of the 30delG mutation and report of two novel mutations in the connexin 26 (GJB2) gene (2001) J Med Genet, 38, pp. e36Yoshinaga-Itano, C., Sedey, A.L., Coulter, D.K., Mehl, A.L., Language of early-and later-identified children with hearing loss (1998) Pediatrics, 102, pp. 1161-117

Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite

Water deprivation-induced thirst is explained by the double-depletion hypothesis, which predicts that dehydration of the two major body fluid compartments, the extracellular and intracellular compartments, activates signals that combine centrally to induce water intake. However, sodium appetite is also elicited by water deprivation. In this brief review, we stress the importance of the water-depletion and partial extracellular fluid-repletion protocol which permits the distinction between sodium appetite and thirst. Consistent enhancement or a de novo production of sodium intake induced by deactivation of inhibitory nuclei (e.g., lateral parabrachial nucleus) or hormones (oxytocin, atrial natriuretic peptide), in water-deprived, extracellular-dehydrated or, contrary to tradition, intracellular-dehydrated rats, suggests that sodium appetite and thirst share more mechanisms than previously thought. Water deprivation has physiological and health effects in humans that might be related to the salt craving shown by our species

Caracterização e Análise dos Processos Produtivos em Empresas Agro-Alimentares

Através de um diagnóstico inicial baseado na análise do conhecimento, informação existente, recolha de informação e medição de parâmetros num conjunto de empresas (60) dos subsetores dos produtos cárneos, hortofrutícolas, lácteos e panificação apresenta-se através do presente relatório a caracterização dos processos e atividades produtivas em empresas do setor agroalimentar. Executando uma análise técnica ao estado da arte, através do estudo da organização das atividades produtivas, nível tecnológico e tendências no desenvolvimento de produtos, permite-se de acordo com a informação disponível realizar uma comparação das empresas em análise com a performance da indústria, globalmente, por região ou setor de atividade. Verifica-se através da análise ao presente relatório, quais os fatores que permitem a criação de valor no setor agroindustrial de uma forma contínua para a cadeia de valor organizacional. Por outro lado, entre os diversos pontos a melhorar, considerando as organizações em análise, destaca-se a cultura de inovação e a digitalização dos processos de produção (Indústria 4.0). Pretende-se, com a aplicação prática do conhecimento gerado pelo presente relatório, a criação de ferramentas que constituam soluções para a melhoria da gestão da produção que promovam a introdução de métodos de inovação na cultura e performance organizacional de forma a tornar as organizações do setor competitivas e com impacto nos mercados internacionais

Caracterização e Análise Energética de Empresas Agro-Alimentares

Através de um diagnóstico inicial baseado na análise do conhecimento, informação existente, recolha de informação e medição de parâmetros num conjunto de 60 empresas dos subsetores dos produtos cárneos, hortofrutícolas, lácteos e panificação, o presente relatório apresenta os resultados da caracterização energética em empresas do setor agroalimentar. Executando uma análise técnica ao estado da arte, através do estudo da organização, de acordo com a informação disponível, é realizada uma comparação das empresas em análise com a performance da indústria, globalmente, por região ou setor de atividade. Verifica-se, através da análise ao presente relatório, quais os fatores que permitem a criação de valor no setor agroindustrial de uma forma contínua para a cadeia de valor organizacional. Por outro lado, entre os diversos pontos a melhorar, considerando as organizações em análise, destaca-se a cultura de inovação e a digitalização dos processos de produção (Indústria 4.0). Pretende-se, com a aplicação prática do conhecimento gerado pelo presente relatório, a criação de ferramentas que constituam soluções para a melhoria da gestão da produção que promovam a introdução de métodos de inovação na cultura e performance organizacional de forma a tornar as organizações do setor competitivas e com impacto nos mercados internacionais