22 research outputs found
New insights into the use and circulation of reindeer antler in northern Iberia during the Magdalenian (ca. 21-13 cal ka BP)
Interactions between prehistoric foragers and reindeer at the end of the Pleistocene are still poorly documented in northern Iberia, particularly the reasons and means by which their antlers were collected, processed and circulated. Here we review the main osseous industries dated to between 21 and 13 cal ka BP, focusing on the use and circulation of reindeer antler as a raw material for the production of weapons and tools by Magdalenian foragers. Thirty-six reindeer antler artefacts were identified from 11 Iberian sites that are located at either end of the Pyrenees: the Cantabrian region to the west, and to a lesser extent, in Catalonia to the east. Despite biases in the identification of production objectives (end-products), a detailed techno-typological, chronological and geographical analysis of these assemblages reveals both the existence of a consistent reindeer antler industry in northern Iberia and long-distance connections between the Cantabrian region and the Pyrenees. The integration of contemporary macrofaunal data makes it possible to explore the extension of the reindeer?s ecological niche in northern Iberia, as well as strategies for the acquisition and circulation of reindeer antler in the peninsula. Assuming that some reindeer assemblages result from the import of raw materials to supply manufacturing activities, we propose a scenario where the acquisition of reindeer antlers may have been organised at a local scale in the Basque region, and potentially in the neighbouring territories of Navarre, Cantabria and Asturias. On the other hand, in Catalonia, the combination of both faunal and technological data supports the hypothesis that reindeer antlers were imported (along with pelts) over longer distances, probably from the northern Pyrenees.This research was primarily financed by an international collaboration between the Spanish Ministry of Science and Innovation (MCIN/AEI/10.13039/501100011033) and the European Union (NextGenerationEU/PRTR) as part of the HumAntler project (PCI2021-122053-2 B) based at the Grupo I + D + i EvoAdapta (UC). Funding was also provided by the UMR-5608 TRACES laboratory of the University of Toulouse and PID2020-114462 GB-I00 of the Spanish Ministry of Science and Innovation (University of Salamanca)
Classes de comprimento e proporção sexual em Diplodon expansus (Mollusca, Bivalvia, Hyriidae) no rio Piraquara, Paraná, Brasil
Desarrollo de un método de extracción asistida por ultrasonidos para la determinación de flavonoides en cebollas (Allium cepa)
Influencia de la maduración del fruto sobre el contenido de compuestos bioactivos en la variedad de pimiento Naga Jolokia
Comparación de la extracción asistida por ultrasonidos y por microondas de capsinoides en pimientos
Optimización y validación de un método de análisis de compuestos fenólicos en uvas mediante cromatografía líquida de ultra-alta eficacia (uhplc-pda-fl)
Membrane Pore Spacing Can Modulate Endothelial Cell–Substrate and Cell–Cell Interactions
Mechanical
cues and substrate interaction affect the manner in
which cells adhere, spread, migrate and form tissues. With increased
interest in tissue-on-a-chip and coculture systems utilizing porous
membranes, it is important to understand the role of disrupted surfaces
on cellular behavior. Using a transparent glass membrane with defined
pore geometries, we investigated endothelial fibronectin fibrillogenesis
and formation of focal adhesions as well as development of intercellular
junctions. Cells formed fewer focal adhesions and had shorter fibronectin
fibrils on porous membranes compared to nonporous controls, which
was similar to cell behavior on continuous soft substrates with Young’s
moduli 7 orders of magnitude lower than glass. Additionally, porous
membranes promoted enhanced cell–cell interactions as evidenced
by earlier formation of tight junctions. These findings suggest that
porous membranes with discontinuous surfaces promote reduced cell–matrix
interactions similarly to soft substrates and may enhance tissue and
barrier formation
Losartán y metformina previenen alteraciones en el tejido adiposo perivascular y en la liberación de prostanoides del lecho vascular mesentérico producidas por una dieta alta en grasa y sobrecarga de fructosa en la rata
Objective: The aim of this study was to analyze the effects of losartan (30 mg/kg/day) and metformin (500 mg/kg/day) on the
adiposity index and on mesenteric vascular bed prostanoid release, and their relationship with systolic blood pressure in a
metabolic syndrome model induced by high-fat high fructose-diet in male Sprague-Dawley rats for 9 weeks.
Methods: Mesenteric vascular beds were extracted and incubated and prostanoids were measured by high-performance liquid
chromatography. Systolic blood pressure was measured by an indirect method.
Results: High-fat high-fructose diet produced significant increase in systolic blood pressure and mesenteric vascular bed
adiposity index and in the release of vasoconstricting prostanoids as thromboxane B2 and prostaglandin F2α and of prostaglandin E2, a marker of inflammation. The PGI2/TXA2 ratio was significantly reduced. The administration of losartan and
metformin prevented all these changes.
Conclusion: Both drugs have beneficial effects on mesenteric perivascular adipose tissue by improving endothelial dysfunction
induced by an imbalance of vasoactive substances.Objetivo: El objetivo de este trabajo fue analizar los efectos del losartán (30 mg/kg/día) y de la metformina (500 mg/kg/día)
sobre el índice de adiposidad y la liberación de prostanoides del lecho vascular mesentérico, así como su relación con la presión
arterial sistólica en un modelo de síndrome metabólico inducido por una dieta alta en grasa y sobrecarga de fructosa en ratas
Sprague-Dawley macho durante 9 semanas.
Material y métodos: Los lechos vasculares mesentéricos extraídos se incubaron y los prostanoides liberados se midieron por
cromatografía líquida de alta eficiencia. La presión arterial sistólica fue medida por método indirecto.
Resultados: La dieta alta en grasa y la sobrecarga de fructosa produjo aumentos significativos en la presión arterial sistólica y
del índice de adiposidad del lecho vascular mesentérico. Por su parte, la dieta alta en grasa y sobrecarga de fructosa incrementó
la liberación de prostanoides vasoconstrictores tanto del tromboxano B2 como de la prostaglandina F2alfa; y del marcador de
inflamación, la prostaglandina E2. La relación PGI2/TXA2 se redujo significativamente. La administración de losartán como
de metformina previnieron todas estas alteraciones.
Conclusión: Ambos fármacos ejercen efectos beneficiosos sobre el tejido adiposo perivascular del lecho mesentérico, lo que
mejora la disfunción endotelial inducida por un desbalance de sustancias vasoactivas