Remodelación e implementación de la Escuelita Sabatina en A. H. Las Torres de San Borja

RESUMEN El presente proyecto de responsabilidad social tiene como propósito la Remodelación de la Escuelita sabatina en A. H. Las Torres de San Borja, que tiene la finalidad de brindar un mejor ambiente de trabajo a los niños de la comunidad, con todos los integrantes del presente curso de la Universidad Privada del Norte. Para la realización de este proyecto se fue al lugar a observar y evaluar las carencias de la escuelita, donde se discutió con todos los integrantes del grupo y se optó por la mejora del ambiente en la escuelita sabatina. Posteriormente se realizó los cambios del ambiente con las donaciones que recibimos y con sugerencias de profesionales para la remodelación, como es el caso de los colores del interior del salón, que nos ayudó un arquitecto para que sea más didáctico y tenga un ambiente de mejor aprendizaje para los alumnos. Al finalizar las actividades de la remodelación de la escuelita, dimos por reinaugurada la escuelita, donde se realizó una charla de concientización con los niños y sus mamás para mantener la limpieza y cuidado de la escuelita, y posterior a eso se realizó un pequeño compartir y juegos con los niños.ABSTRACT The purpose of this social responsibility project is to remodel the School sabattine in A. H. Las Torres de San Borja, which aims to provide a better working environment for the children of the community, with all the members of the present course of the Private University of North. For the realization of this project went to the place to observe and assess the shortcomings of the school, where it was discussed with all the members of the group and opted for the improvement of the environment in the school Saturday. Subsequently the changes of the environment were made with the donations we received and with suggestions from professionals for the remodeling, as is the case of the colors of the interior of the room, which helped us an architect to be more didactic and have a better learning environment for the students. At the end of the activities of the remodeling of the school, we reopened the school, where an awareness-raising talk was held with the children and their mothers to maintain the cleanliness and care of the school, and after that a small sharing and games with children

Stereoselective Synthesis of (-)-Spicigerolide

(-)-Spicigerolide was enantioselectively synthesized from a protected (S)-lactaldehyde. The synthesis of the polyacetylated framework relied on two Zn-mediated stereoselective additions of alkynes to aldehydes as well as a regiocontrolled [3,3]-sigmatropic rearrangement of an allylic acetate. The pyranone moiety was constructed via ring-closing metathesis

A 3D REPOSITORY OF DINOSAUR TEETH: THE GENERATION OF OPEN RESOURCES FOR THE CLASSIFICATION AND IDENTIFICATION OF SPECIMENS

Among the many valuable uses of the artificial intelligence in the field of museums, it may assist the classification of out-of-context items. This paper deals with the problem of the identification of dinosaur teeth (a type of fossil that is usually found scattered), which can be tackled by means of multivariate algorithms (such as the principal components, discriminant or cluster analyses) taking as a starting point a series of morphometric values (i.e., distances between specific points of the fossil tooth). A good interpretation requires some comprehension regarding the mathematical algorithms that are used, as well as the specific knowledge in palaeontology that permits appreciating the actual reach of the results. However, based on metric values as the computations are, there must also be some control over their precision and the possibility of checking the old measurements or complete the list of morphometric variables. This is an aspect that may be solved if the three-dimensional models of the teeth are made publicly available.The text describes the 3D documentation of a set of twelve fossil teeth of the museum of Natural Sciences of Álava (Vitoria-Gasteiz, Spain) —approximately from 1 to 6 cm in size— using a structured light scanner and close-up photographs for recording some features smaller than the resolution of the scanner. The information about each tooth was then packed and uploaded to the university repository, from where it is also accessible via cultural and scientific aggregators (such as Europeana); likewise, reduced resolution copies are also accessible in the commercial platform Sketchfab&reg;.</p

Antimicrobial and Efflux Pump Inhibitory Activity of Caffeoylquinic Acids from Artemisia absinthium against Gram-Positive Pathogenic Bacteria

Background: Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative treatments. One plausible antimicrobial alternative could be the combination of conventional antimicrobial agents/antibiotics with small molecules which block multidrug efflux systems known as efflux pump inhibitors. Bioassay-driven purification and structural determination of compounds from plant sources have yielded a number of pump inhibitors which acted against gram positive bacteria. Methodology/Principal Findings: In this study we report the identification and characterization of 4′,5′-O-dicaffeoylquinic acid (4′,5′-ODCQA) from Artemisia absinthium as a pump inhibitor with a potential of targeting efflux systems in a wide panel of Gram-positive human pathogenic bacteria. Separation and identification of phenolic compounds (chlorogenic acid, 3′,5′-ODCQA, 4′,5′-ODCQA) was based on hyphenated chromatographic techniques such as liquid chromatography with post column solid-phase extraction coupled with nuclear magnetic resonance spectroscopy and mass spectroscopy. Microbial susceptibility testing and potentiation of well know pump substrates revealed at least two active compounds; chlorogenic acid with weak antimicrobial activity and 4′,5′-ODCQA with pump inhibitory activity whereas 3′,5′-ODCQA was ineffective. These intitial findings were further validated with checkerboard, berberine accumulation efflux assays using efflux-related phenotypes and clinical isolates as well as molecular modeling methodology. Conclusions/Significance: These techniques facilitated the direct analysis of the active components from plant extracts, as well as dramatically reduced the time needed to analyze the compounds, without the need for prior isolation. The calculated energetics of the docking poses supported the biological information for the inhibitory capabilities of 4′,5′-ODCQA and furthermore contributed evidence that CQAs show a preferential binding to Major Facilitator Super family efflux systems, a key multidrug resistance determinant in gram-positive bacteria.National Institutes of Health (U.S.) (grant R01GM59903)National Institutes of Health (U.S.) (grant R01AI050875)Netherlands Organization for Scientific Research (VICI grant 700.56.442)Massachusetts Technology Transfer Center (MTTC)National Institutes of Health (U.S.) (grant 5U54MH084690-02

Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines

The Advisory group on Consensus statement on the Phytochemical Characterisation of Medicinal Plant extracts (ConPhyMP) is a consortium of experts on Pharmacognosy and Phytochemistry open access articleBackground: Research onmedicinal plants and extracts derived fromthem differs from studies performed with single compounds. Extracts obtained from plants, algae, fungi, lichens or animals pose some unique challenges: they are multicomponent mixtures of active, partially active and inactive substances, and the activity is often not exerted on a single target. Their composition varies depending on the method of preparation and the plant materials used. This complexity and variability impact the reproducibility and interpretation of pharmacological, toxicological and clinical research. Objectives: This project develops best practice guidelines to ensure reproducibility and accurate interpretations of studies using medicinal plant extracts. The focus is on herbal extracts used in pharmacological, toxicological, and clinical/intervention research. Specifically, the consensus-based statement focuses on defining requirements for: 1) Describing the plant material/herbal substances, herbal extracts and herbal medicinal products used in these studies, and 2) Conducting and reporting the phytochemical analysis of the plant extracts used in these studies in a reproducible and transparent way. The process and methods: We developed the guidelines through the following process: 1) The distinction between the three main types of extracts (extract types A, B, and C), initially conceptualised by the lead author (MH), led the development of the project as such; 2) A survey among researchers of medicinal plants to gather global perspectives, opportunities, and overarching challenges faced in characterising medicinal plant extracts under different laboratory infrastructures. The survey responses were central to developing the guidelines and were reviewed by the core group; 3) A core group of 9 experts met monthly to develop the guidelines through a Delphi process; and. 4) The final draft guidelines, endorsed by the core group, were also distributed for feedback and approval to an extended advisory group of 20 experts, including many journal editors. Outcome: The primary outcome is the “Consensus statement on the Phytochemical Characterisation of Medicinal Plant extracts“ (ConPhyMP) which defines the best practice for reporting the starting plant materials and the chemical methods recommended for defining the chemical compositions of the plant extracts used in such studies. The checklist is intended to be an orientation for authors in medicinal plant research as well as peer reviewers and editors assessing such research for publicatio

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group