Minorca, an exotic Balearic island (western Mediterranean)

Despite forming part of the Balearic group of islands, Minorca differs stratigraphically and structurally from Majorca and Ibiza: i) Paleozoic rocks are abundant in Minorca but are very scarce in Majorca and are absent in Ibiza. Eocene-Oligocene sediments are virtually absent in Minorca but crop out extensively in Majorca, ii) Contractional structures in Minorca differ in direction (aligned SW-NE in Majorca and Ibiza and N-S in Minorca) and in age from those in Majorca and Ibiza. In addition, Paleozoic deposits of Minorca do not correlate with those of Sardinia, where in addition the Triassic sediments are not very abundant. Contractional deformation in Sardinia is in part older (late Eocene-early Miocene) than in Minorca (early Miocene?). Given its Neogene clockwise rotation, Minorca cannot be considered a small block dragged by the early Miocene counter clockwise rotation of the Corsica-Sardinia block. Furthermore, the Paleozoic and Mesozoic stratigraphy of Minorca (siliciclasticlate Paleozoic rocks, Triassic Germanic facies and Jurassic carbonates) has affinities with that of the southern part of the Catalan Coastal Ranges. Thus, of all the Balearic islands, Minorca seems to have traveled the farthest during the Valencia Trough rifting with the result that it resembles an exotic island forming part of the Balearic foreland

Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer

Background:We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, pharmacodynamic activity and identify the recommended dose.Methods:Fourteen patients were treated with intralesional injections containing 35 or 70 mg of CIGB-300 in three alternate cycles of three consecutive days each before standard chemoradiotherapy. Tumour uptake was determined using 99 Tc-radiolabelled peptide. In situ B23/nucleophosmin was determined by immunohistochemistry.Results:Maximum tumour uptake for CIGB-300 70-mg dose was significantly higher than the one observed for 35 mg: 16.1±8.9 vs 31.3±12.9 mg (P=0.01). Both, AUC 24h and biological half-life were also significantly higher using 70 mg of CIGB-300 (P<0.001). Unincorporated CIGB-300 diffused rapidly to blood and was mainly distributed towards kidneys, and marginally in liver, lungs, heart and spleen. There was no DLT and moderate allergic-like reactions were the most common systemic side effect with strong correlation between unincorporated CIGB-300 and histamine levels in blood. CIGB-300, 70 mg, downregulated B23/nucleophosmin (P=0.03) in tumour specimens.Conclusion:Intralesional injections of 70 mg CIGB-300 in two sites (0.5 ml per injection) and this treatment plan are recommended to be evaluated in phase 2 studies.Fil: Sarduy, M. R.. Medical-surgical Research Center; CubaFil: García, I.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Coca, M. A.. Clinical Investigation Center; CubaFil: Perera, A.. Clinical Investigation Center; CubaFil: Torres, L. A.. Clinical Investigation Center; CubaFil: Valenzuela, C. M.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Baladrón, I.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Solares, M.. Hospital Materno Ramón González Coro; CubaFil: Reyes, V.. Center For Genetic Engineering And Biotechnology Havana; CubaFil: Hernández, I.. Isotope Center; CubaFil: Perera, Y.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Martínez, Y. M.. Medical-surgical Research Center; CubaFil: Molina, L.. Medical-surgical Research Center; CubaFil: González, Y. M.. Medical-surgical Research Center; CubaFil: Ancízar, J. A.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Prats, A.. Clinical Investigation Center; CubaFil: González, L.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Casacó, C. A.. Clinical Investigation Center; CubaFil: Acevedo, B. E.. Centro de Ingeniería Genética y Biotecnología; CubaFil: López Saura, P. A.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; ArgentinaFil: Gómez, R.. Elea Laboratories; ArgentinaFil: Perea Rodríguez, S. E.. Center For Genetic Engineering And Biotechnology Havana; Cuba. Centro de Ingeniería Genética y Biotecnología; Cub

High quality optically active and integrable EuOOH films prepared by pulsed laser deposition

Rare-earth (RE)-Oxygen-Hydrogen compounds are versatile materials whose composition and properties can be significantly varied by changing the relative O and H contents. Among them hydrides and oxyhydrides have been thoroughly investigated due to its photochromic properties. Instead, research of RE-hydroxides and oxyhydroxides (RE-OH and RE-OOH) is scarce although they show promising properties as light emitters. However, their use and integration in solid state devices have been hindered so far because their usual chemical synthesis routes yield materials in bulk or powder configurations. In this work we demonstrate a physical deposition route based on pulsed laser deposition that results in the unprecedented preparation of high-quality Eu oxyhydroxide (EuOOH) thin films. The synthetized EuOOH films show a well-defined monoclinic structure, are optically active and show a robust red emission related to the intra-f transitions of the Eu3+ ions. The excellent quality of these crystalline films has allowed us to obtain relevant properties of the monoclinic EuOOH phase not previously reported such as its refractive index and its Raman spectrum, including the identification of the characteristic phonon modes. These novel EuOOH films have been prepared both on Si and fused silica substrates, and thus are ready for potential integration in solid state optoelectronic components and devicesThis work was funded by the Spanish Research Agency (AEI, Ministry of Research and Innovation) and the European Regional Development Fund (ERDF) under grants RTI2018-096498-B-I00, RTI2018-101020-B-I00, RTI2018-096918-B-C41 and PID2021-123190OB-I00; by the CSIC (PIE-202050E195 and project 2021AEP128IO); by the Regional Government of Madrid through TECHNOFUSION(III)CM ´ (S2018/EMT-4437); and by Comunidad de Madrid (Spain) multiannual agreement with UC3M, “Excelencia para el Profesorado Universitario” (EPUC3M14) - Fifth regional research plan 2016-2020. The work of A. Cano was partially supported by the Autonomous Community of Madrid and the European Social Fund (PEJD-2019-PRE/TIC-16082

Enfermedades congénitas e identificación

X Congreso Nacional de Paleopatología. Univesidad Autónoma de Madrid, septiembre de 200

Systematic trends in beta-delayed particle emitting nuclei: The case of beta-p-alpha emission from 21Mg

We have observed beta+-delayed alpha and p-alpha emission from the proton-rich nucleus 21Mg produced at the ISOLDE facility at CERN. The assignments were cross-checked with a time distribution analysis. This is the third identified case of beta-p-alpha emission. We discuss the systematic of beta-delayed particle emission decays, show that our observed decays fit naturally into the existing pattern, and argue that the patterns are to a large extent caused by odd-even effects.Comment: 6 pages, 5 figure

S’Estret des Temps: registro cuaternario, eolianitas y estructuras asociadas

Abstract not availabl