Vacunas contra la COVID-19

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Vacunes; Errors de medicacióCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Vacunas; Errores de medicaciónCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Vaccines; Medication errorsActualment, el repte més important del sistema sanitari català és controlar la pandèmia produïda pel coronavirus 2 de la síndrome respiratòria aguda greu (SARS-CoV-2) o virus de la COVID-19 mitjançant la vacunació poblacional amb l’objectiu d’aconseguir que tota la població estigui protegida, directament amb la vacunació poblacional de les persones de 16 anys i més i, indirectament, la resta de la població per l’efecte d’immunitat de grup.Actualmente, el reto más importante del sistema sanitario catalán es controlar la pandemia producida por el coronavirus 2 del síndrome respiratorio agudo grave (SARS-CoV-2) o virus de la COVID-19 mediante la vacunación poblacional con el objetivo de conseguir que toda la población esté protegida, directamente con la vacunación poblacional de las personas de 16 años y más e, indirectamente, el resto de la población por el efecto de inmunidad de grupo

Origin and history of Phoxinus (Cyprinidae) introductions in the Douro basin (Iberian Peninsula): an update inferred from genetic data

The number of non-native freshwater fishes in the Iberian Peninsula has been greatly increasing. In this study, individuals of the genus Phoxinus were detected in 18 out of 138 stream sites sampled across the Douro Basin in 2017 and 2018. A total of 26 individuals were barcoded using partial cytochrome c oxidase subunit I (COI) and cytochrome b (cytb) genes for species identification and determination of geographical origin. Molecular data provided the first record of a second Phoxinus species in western Douro (Portugal, Iberian Peninsula), with haplotypes closely matching those found in the Charente River (southern France). This species is suspected to be a recent introduction associated with the use of minnows as live bait by freshwater anglers, which was facilitated by human movements between France and Portugal. Individuals from watercourses in eastern Douro (Spain) were genetically assigned to Phoxinus bigerri, an introduced species previously known for that region, which confirms reports of introduction events from Ebro to Douro Basin probably also related to freshwater angling and facilitated by geographic proximity. The potential ecological impacts of this genus in the region are unknown and need further investigation.We acknowledge Fernando Teixeira, Fernando Miranda, Mario Ferreira, Sara Carona, Jose Pedro RamiAo and Francisco Carvalho for the valuable assistance during fieldwork. We specially thank Maria Filomena MagalhAes for previous fruitful discussions and logistic support. We are grateful to Matthias F. Geiger and Andrea Corral Lou for facilitating genetic data and coordinates of sampling sites. Finally, we appreciate the comments of the three anonymous reviewers that improved the quality of the manuscript. AFF and AGR were supported by the project FRESHING founded by the Portuguese Foundation for Science and Technology (FCT) and COMPETE (PTDC/AAGMAA/2261/2014 - POCI-01-0145-FEDER-356016824). FMSM was supported by the FCT PhD grant SFRH/BD/104703/2014. This study was conducted as part of the projects FRESHING and FRESHCO. The latter is also supported by FCT and COMPETE (PTDC/AGR-FOR/1627/2014 - 04/SAICT/2015) and UID/AGR/04033/2019. Logistic support was also facilitated by the ENVMETAGEN - Capacity Building at InBIO for Research and Innovation Using Environmental Metagenomics project at CIBIO laboratories (668981; EUH2020-WIDESPREAD-2014-2)

El Butlletí Epidemiològic de Catalunya: pas a pas i bona lletra: cap a una revista dʼarticles revisats per experts

Normes de publicació; Procés editorial; Publicacions del Departament de SalutNormas de publicación; Proceso editorial; Publicaciones del Departamento de SaludPublication standards; Publishing process; Department of Health publicationsEl Butlletí Epidemiològic de Catalunya (BEC) és la publicació de referència dels articles generats pels professionals de la salut pública del Departament de Salut. En aquesta nota editorial es revisen els continguts dels articles publicats al llarg de 2013, es presenta lʼactualització del procés de publicació i autoria que han de seguir els articles enviats a la revista i les propostes del Consell de Redacció del BEC per als propers anys.El Boletín Epidemiológico de Cataluña (BEC) es la publicación de referencia de los artículos generados por profesionales de la salud pública del Departamento de Salud. Esta nota editorial revisa el contenido de los artículos publicados a lo largo de 2013, se presenta la actualización de la publicación del proceso editorial y autoría que han de seguir los artículos enviados a la revista y las propuestas del Consejo de Redacción del BEC en los próximos años.The Epidemiological Bulletin for Catalonia (BEC) is the publication of reference on articles written by public health professionals of the Catalan Ministry of Health. This editorial note reviews the contents of articles published during 2013 and presents an update of the process of publication and authorship that should follow articles sent to the journal and proposals by the Editorial Board for the coming years

Selective loss of kisspeptin signaling in oocytes causes progressive premature ovulatory failure

Study question: Does direct kisspeptin signaling in the oocyte have a role in the control of follicular dynamics and ovulation?Summary answer: Kisspeptin signaling in the oocyte plays a relevant physiological role in the direct control of ovulation; oocyte-specific ablation of kisspeptin receptor, Gpr54, induces a state of premature ovulatory failure in mice that recapitulates some features of premature ovarian insufficiency (POI).What is known already: Kisspeptins, encoded by the Kiss1 gene, are essential for the control of ovulation and fertility, acting primarily on hypothalamic GnRH neurons to stimulate gonadotropin secretion. However, kisspeptins and their receptor, Gpr54, are also expressed in the ovary of different mammalian species, including humans, where their physiological roles remain contentious and poorly characterized.Study design, size, duration: A novel mouse line with conditional ablation of Gpr54 in oocytes, named OoGpr54-/-, was generated and studied in terms of follicular and ovulatory dynamics at different age-points of postnatal maturation. A total of 59 OoGpr54-/- mice and 47 corresponding controls were analyzed. In addition, direct RNA sequencing was applied to ovarian samples from 8 OoGpr54-/- and 7 control mice at 6 months of age, and gonadotropin priming for ovulatory induction was conducted in mice (N = 7) from both genotypes.Participants/materials, setting, methods: Oocyte-selective ablation of Gpr54 in the oocyte was achieved in vivo by crossing a Gdf9-driven Cre-expressing transgenic mouse line with a Gpr54 LoxP mouse line. The resulting OoGpr54-/- mouse line was subjected to phenotypic, histological, hormonal and molecular analyses at different age-points of postnatal maturation (Day 45, and 2, 4, 6 and 10-11 months of age), in order to characterize the timing of puberty, ovarian follicular dynamics and ovulation, with particular attention to identification of features reminiscent of POI. The molecular signature of ovaries from OoGpr54-/- mice was defined by direct RNA sequencing. Ovulatory responses to gonadotropin priming were also assessed in OoGpr54-/- mice.Main results and the role of chance: Oocyte-specific ablation of Gpr54 caused premature ovulatory failure, with some POI-like features. OoGpr54-/- mice had preserved puberty onset, without signs of hypogonadism. However, already at 2 months of age, 40% of OoGpr54-/- females showed histological features reminiscent of ovarian failure and anovulation. Penetrance of the phenotype progressed with age, with >80% and 100% of OoGpr54-/- females displaying complete ovulatory failure by 6- and 10 months, respectively. This occurred despite unaltered hypothalamic Gpr54 expression and gonadotropin levels. Yet, OoGpr54-/- mice had decreased sex steroid levels. While the RNA signature of OoGpr54-/- ovaries was dominated by the anovulatory state, oocyte-specific ablation of Gpr54 significantly up- or downregulated of a set of 21 genes, including those encoding pituitary adenylate cyclase-activating polypeptide, Wnt-10B, matrix-metalloprotease-12, vitamin A-related factors and calcium-activated chloride channel-2, which might contribute to the POI-like state. Notably, the anovulatory state of young OoGpr54-/- mice could be rescued by gonadotropin priming.Large scale data: N/A. .Limitations, reasons for caution: Conditional ablation of Gpr54 in oocytes unambiguously caused premature ovulatory failure in mice; yet, the ultimate molecular mechanisms for such state of POI can be only inferred on the basis of RNAseq data and need further elucidation, since some of the molecular changes observed in OoGpr54-/- ovaries were secondary to the anovulatory state. Direct translation of mouse findings to human disease should be made with caution since, despite the conserved expression of Kiss1/kisspeptin and Gpr54 in rodents and humans, our mouse model does not recapitulate all features of common forms of POI.Wider implications of the findings: Deregulation of kisspeptin signaling in the oocyte might be an underlying, and previously unnoticed, cause for some forms of POI in women.Study funding/competing interest(s): This work was primarily supported by a grant to M.P. and M.T.-S. from the FiDiPro (Finnish Distinguished Professor) Program of the Academy of Finland. Additional financial support came from grant BFU2017-83934-P (M.T.-S.; Ministerio de Economía y Competitividad, Spain; co-funded with EU funds/FEDER Program), research funds from the IVIRMA International Award in Reproductive Medicine (M.T.-S.), and EFSD Albert Renold Fellowship Programme (S.T.R.). The authors have no conflicts of interest to declare in relation to the contents of this work.</p

Formation of left-handed helices by C2′-fluorinated nucleic acids under physiological salt conditions

Recent findings in cell biology have rekindled interest in Z-DNA, the left-handed helical form of DNA. We report here that two minimally modified nucleosides, 2'F-araC and 2'F-riboG, induce the formation of the Z-form under low ionic strength. We show that oligomers entirely made of these two nucleosides exclusively produce left-handed duplexes that bind to the Zα domain of ADAR1. The effect of the two nucleotides is so dramatic that Z-form duplexes are the only species observed in 10 mM sodium phosphate buffer and neutral pH, and no B-form is observed at any temperature. Hence, in contrast to other studies reporting formation of Z/B-form equilibria by a preference for purine glycosidic angles in syn, our NMR and computational work revealed that sequential 2'F…H2N and intramolecular 3'H…N3' interactions stabilize the left-handed helix. The equilibrium between B- and Z- forms is slow in the 19F NMR time scale (≥ms), and each conformation exhibited unprecedented chemical shift differences in the 19F signals. This observation led to a reliable estimation of the relative population of B and Z species and enabled us to monitor B-Z transitions under different conditions. The unique features of 2'F-modified DNA should thus be a valuable addition to existing techniques for specific detection of new Z-binding proteins and ligands

Guide to the alien and invasive species of rivers, lakes and estuaries in the Iberian Peninsula.

Guide to the alien and invasive species of rivers, lakes and estuaries in the Iberian Peninsula

El Butlletí Epidemiològic de Catalunya: balanç i perspectives

Autors; Revisió; ArticlesAuthors; Review; ArticlesAutores; Revisión; ArtículosLʼobjectiu dʼaquest editorial és revisar els articles del BEC publicats a Internet en els darrers mesos, presentar els objectius i les propostes per als propers anys i indicar als autors quin és el procés de publicació i la manera de consignar lʼautoria dels articles enviats al Butlletí.The aim of this editorial is to review BEC articles published on Internet the last months, present the aims and proposals for the coming years and explain to authors which is the publishing process and also the way to consign authorship for articles sent to the Butlletí.El objetivo de este editorial es revisar los artículos del BEC publicados en Internet en los últimos meses, presentar los objetivos y las propuestas para los próximos años e indicar a los autores cuál es el proceso de publicación y el modo de consignar la autoría de los artículos enviados al Butlletí

A horizon scan exercise for aquatic invasive alien species in Iberian inland waters

As the number of introduced species keeps increasing unabatedly, identifying and prioritising current and potential Invasive Alien Species (IAS) has become essential to manage them. Horizon Scanning (HS), defined as an exploration of potential threats, is considered a fundamental component of IAS management. By combining scientific knowledge on taxa with expert opinion, we identified the most relevant aquatic IAS in the Iberian Peninsula, i.e., those with the greatest geographic extent (or probability of introduction), severe ecological, economic and human health impacts, greatest difficulty and acceptability of management. We highlighted the 126 most relevant IAS already present in Iberian inland waters (i.e., Concern list) and 89 with a high probability of being introduced in the near future (i.e., Alert list), of which 24 and 10 IAS, respectively, were considered as a management priority after receiving the highest scores in the expert assessment (i.e., top-ranked IAS). In both lists, aquatic IAS belonging to the four thematic groups (plants, freshwater invertebrates, estuarine invertebrates, and vertebrates) were identified as having been introduced through various pathways from different regions of the world and classified according to their main functional feeding groups. Also, the latest update of the list of IAS of Union concern pursuant to Regulation (EU) No 1143/2014 includes only 12 top-ranked IAS identified for the Iberian Peninsula, while the national lists incorporate the vast majority of them. This fact underlines the great importance of taxa prioritisation exercises at biogeographical scales as a step prior to risk analyses and their inclusion in national lists. This HS provides a robust assessment and a cost-effective strategy for decision-makers and stakeholders to prioritise the use of limited resources for IAS prevention and management. Although applied at a transnational level in a European biodiversity hotspot, this approach is designed for potential application at any geographical or administrative scale, including the continental one

Código de conduta. Aquariofilia

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Corrigendum to ‘a horizon scan exercise for aquatic invasive alien species in Iberian inland waters’

info:eu-repo/semantics/publishedVersio