2,746 research outputs found
Use of high L.E.T. radiation to improve adhesion of metals to polytetrafluoroethylene
MgK alpha X-rays (1254 eV) and 2 keV electrons irradiate the surface of polytetrafluoro ethylene (PTFE). The damage is confined to a few tenths of a micron below the surface, and the doses exceed 10 to the eight power rad. X-ray Photoelectron Spectroscopy (XPS) of the irradiated surfaces and mass spectroscopy of the gaseous products of irradiation indicate that the damaged layer is crosslinked or branched PTFE. After either type of irradiation, the surface has enhanced affinity for metals and a lower contact angle with hexadecane. Tape pull tests show that evaporated Ni and Au films adhere better to the irradiated surface. XPS shows the Ni interacts chemically with PTFE forming NiF2 and possibly NiC. However, the gold adhesion and contact angle results indicate that the interaction is, at least in part, chemically nonspecific. Decreased contact angles on FEP Teflon crystallized against gold were attributed to either the presence of a polar oxygen layer or increased physical forces due to greater density. In the case of irradiated PTFE, no oxygen on the surface was observed. The crosslinked structure might, however, have a greater density, thus accounting for the observed increase in adhesion and wettability
Thermal desorption study of physical forces at the PTFE surface
Thermal desorption spectroscopy (TDS) of the polytetrafluoroethylene (PTFE) surface was successfully employed to study the possibile role of physical forces in the enhancement of metal-PTFE adhesion by radiation. The thermal desorption spectra were analyzed without assumptions to yield the activation energy for desorption over a range of xenon coverage from less than 0.1 monolayer to more than 100 monolayers. For multilayer coverage, the desorption is zero-order with an activation energy equal to the sublimation energy of xenon. For submonolayer coverages, the order for desorption from the unirradiated PTFE surface is 0.73 and the activation energy for desorption is between 3.32 and 3.36 kcal/mol; less than the xenon sublimation energy. The effect of irradiation is to increase the activation energy for desorption to as high as 4 kcal/mol at low coverage
Opto-mechanical micro-macro entanglement
We propose to create and detect opto-mechanical entanglement by storing one
component of an entangled state of light in a mechanical resonator and then
retrieving it. Using micro-macro entanglement of light as recently demonstrated
experimentally, one can then create opto-mechanical entangled states where the
components of the superposition are macroscopically different. We apply this
general approach to two-mode squeezed states where one mode has undergone a
large displacement. Based on an analysis of the relevant experimental
imperfections, the scheme appears feasible with current technology.Comment: 7 pages, 6 figures, to appear in PRL, submission coordinated with
Sekatski et al. who reported on similar result
Parallel quantized charge pumping
Two quantized charge pumps are operated in parallel. The total current
generated is shown to be far more accurate than the current produced with just
one pump operating at a higher frequency. With the application of a
perpendicular magnetic field the accuracy of quantization is shown to be 20
ppm for a current of pA. The scheme for parallel pumping presented in
this work has applications in quantum information processing, the generation of
single photons in pairs and bunches, neural networking and the development of a
quantum standard for electrical current. All these applications will benefit
greatly from the increase in output current without the characteristic decrease
in accuracy as a result of high-frequency operation
Characterizing the Rigidly Rotating Magnetosphere Stars HD 345439 and HD 23478
The SDSS III APOGEE survey recently identified two new Ori E type
candidates, HD 345439 and HD 23478, which are a rare subset of rapidly rotating
massive stars whose large (kGauss) magnetic fields confine circumstellar
material around these systems. Our analysis of multi-epoch photometric
observations of HD 345439 from the KELT, SuperWASP, and ASAS surveys reveals
the presence of a 0.7701 day period in each dataset, suggesting the
system is amongst the faster known Ori E analogs. We also see clear
evidence that the strength of H-alpha, H I Brackett series lines, and He I
lines also vary on a 0.7701 day period from our analysis of multi-epoch,
multi-wavelength spectroscopic monitoring of the system from the APO 3.5m
telescope. We trace the evolution of select emission line profiles in the
system, and observe coherent line profile variability in both optical and
infrared H I lines, as expected for rigidly rotating magnetosphere stars. We
also analyze the evolution of the H I Br-11 line strength and line profile in
multi-epoch observations of HD 23478 from the SDSS-III APOGEE instrument. The
observed periodic behavior is consistent with that recently reported by Sikora
and collaborators in optical spectra.Comment: Accepted in ApJ
Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers
Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB activation. In this study, we identified a group of novel C8-linked benzofused Pyrrolo[2,1-c][1,4]benzodiazepines (PBD) monomeric hybrids capable of sequence-selective inhibition of NF-κB with low nanomolar LD50 values in CLL (n=46) and MM cell lines (n=5). The lead compound, DC-1-192, significantly inhibited NF-κB DNA binding after just 4h exposure and demonstrating inhibitory effects on both canonical and non-canonical NF-κB subunits. In primary CLL cells, sensitivity to DC-1-192 was inversely correlated with RelA subunit expression (r2=0.2) and samples with BIRC3 or NOTCH1 mutations showed increased sensitivity (P=0.001). RNA-sequencing and gene set enrichment analysis confirmed the over-representation of NF-κB regulated genes in the down-regulated gene list. Furthermore, In vivo efficacy studies in NOD/SCID mice, using a systemic RPMI 8226 human multiple myeloma xenograft model, showed that DC-1-192 significantly prolonged survival (P=0.017). In addition, DC1-192 showed synergy with bortezomib and ibrutinib; synergy with ibrutinib was enhanced when CLL cells were co-cultured on CD40L-expressing fibroblasts in order to mimic the cytoprotective lymph node microenvironment (P = 0.01). Given that NF-κB plays a role in both bortezomib and ibrutinib resistance mechanisms, these data provide a strong rationale for the use of DC-1-192 in the treatment of NF-κB-driven cancers, particularly in the context of relapsed/refractory disease
Group treatments for sensitive health care problems : a randomised controlled trial of group versus individual physiotherapy sessions for female urinary incontinence
Background: The aim was to compare effectiveness of group versus individual sessions of physiotherapy in terms of symptoms, quality of life, and costs, and to investigate the effect of patient preference on uptake and outcome of treatment.
Methods: A pragmatic, multi-centre randomised controlled trial in five British National Health Service physiotherapy departments. 174 women with stress and/or urge incontinence were randomised to receive treatment from a physiotherapist delivered in a group or individual setting over three weekly sessions. Outcome were measured as Symptom Severity Index; Incontinence-related Quality of Life questionnaire; National Health Service costs, and out of pocket expenses.
Results: The majority of women expressed no preference (55%) or preference for individual treatment (36%). Treatment attendance was good, with similar attendance with both service delivery models. Overall, there were no statistically significant differences in symptom severity or quality of life outcomes between the models. Over 85% of women reported a subjective benefit of treatment, with a slightly higher rating in the individual compared with the group setting. When all health care costs were considered, average cost per patient was lower for group sessions (Mean cost difference £52.91 95%, confidence interval (£25.82 - £80.00)).
Conclusion: Indications are that whilst some women may have an initial preference for individual treatment, there are no substantial differences in the symptom, quality of life outcomes or non-attendance. Because of the significant difference in mean cost, group treatment is recommended
Metal-insulator transition at B=0 in a dilute two dimensional GaAs-AlGaAs hole gas
We report the observation of a metal insulator transition at B=0 in a high
mobility two dimensional hole gas in a GaAs-AlGaAs heterostructure. A clear
critical point separates the insulating phase from the metallic phase,
demonstrating the existence of a well defined minimum metallic conductivity
sigma(min)=2e/h. The sigma(T) data either side of the transition can be
`scaled' on to one curve with a single parameter (To). The application of a
parallel magnetic field increases sigma(min) and broadens the transition. We
argue that strong electron-electron interactions (rs = 10) destroy phase
coherence, removing quantum intereference corrections to the conductivity.Comment: 4 pages RevTex + 4 figures. Submitted to PRL. Originally posted 22
September 1997. Revised 12 October 1997 - minor changes to referencing,
figure cations and figure
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