3,394 research outputs found
The KELT-South Telescope
The Kilodegree Extremely Little Telescope (KELT) project is a survey for new
transiting planets around bright stars. KELT-South is a small-aperture,
wide-field automated telescope located at Sutherland, South Africa. The
telescope surveys a set of 26 degree by 26 degree fields around the southern
sky, and targets stars in the range of 8 < V < 10 mag, searching for transits
by Hot Jupiters. This paper describes the KELT-South system hardware and
software and discusses the quality of the observations. We show that KELT-South
is able to achieve the necessary photometric precision to detect transits of
Hot Jupiters around solar-type main-sequence stars.Comment: 26 pages, 13 figure
Designing a Minimal-Knowledge Controller to Achieve Fast, Stable Growth for Recombinant Escherichia coli Cultures
The biopharmaceutical industry is constantly developing new recombinant Es-cherichia coli strains to bring new products to market. In early stages of development, small scale bioreactors are used to make the product and explore di˙erent growth pro-tocols. Researchers spend significant time finding a feed rate profile that will give fast growth and low byproduct accumulation. The objective for the controller pre-sented in this work is to achieve fast growth and low acetate accumulation for an E.coli fermentation. The controller does not rely on previous characterization data or models but on fundamental metabolic relationships between oxygen and glucose as dictated by the Crabtree e˙ect. The controller senses metabolic state using an on-line oxygen uptake rate (OUR) estimate and pushes the culture to the boundary of oxidative and overflow metabolism (BOOM). A simulated E.coli culture and biore-actor were constructed to test controller performance. Fermentation experiments compared the BOOM controller to an Exponential feed and a DO-stat controller. Using minimal knowledge about the strain, the BOOM controller kept an induced E.coli MG1655 pTVP1GFP strain growing near the boundary of oxidative and over-flow metabolism. The BOOM controller produced more recombinant protein than the Exponential feed controller and the DO-stat controller, even though the growth rate used by the Exponential feed controller was extensively researched by a previous group. In another fermentation, the temperature was lowered to incur a fast change in the E.coli metabolism. In all experiments, the BOOM controller demonstrated it could maintain fast growth and avoid inhibitory acetate concentrations while requir-ing minimal knowledge of theE.coli MG1655 pTVP1GFP strain. For laboratories which deal with many di˙erent strains and proteins, the BOOM controller would maximize protein production and speed up protocol development
Upper-division Student Understanding of Coulomb's Law: Difficulties with Continuous Charge Distributions
Utilizing the integral expression of Coulomb's Law to determine the electric
potential from a continuous charge distribution is a canonical exercise in
Electricity and Magnetism (E&M). In this study, we use both think-aloud
interviews and responses to traditional exam questions to investigate student
difficulties with this topic at the upper-division level. Leveraging a
theoretical framework for the use of mathematics in physics, we discuss how
students activate, construct, execute and reflect on the integral form of
Coulomb's Law when solving problems with continuous charge distributions. We
present evidence that junior-level E&M students have difficulty mapping
physical systems onto the mathematical expression for the Coulomb potential.
Common challenges include difficulty expressing the difference vector in
appropriate coordinates as well as determining expressions for the differential
charge element and limits of integration for a specific charge distribution. We
discuss possible implications of these findings for future research directions
and instructional strategies.Comment: 5 pages, 1 figure, 2 tables, accepted to 2012 PERC Proceeding
ACER: A Framework on the Use of Mathematics in Upper-division Physics
At the University of Colorado Boulder, as part of our broader efforts to
transform middle- and upper-division physics courses, we research students'
difficulties with particular concepts, methods, and tools in classical
mechanics, electromagnetism, and quantum mechanics. Unsurprisingly, a number of
difficulties are related to students' use of mathematical tools (e.g.,
approximation methods). Previous work has documented a number of challenges
that students must overcome to use mathematical tools fluently in introductory
physics (e.g., mapping meaning onto mathematical symbols). We have developed a
theoretical framework to facilitate connecting students' difficulties to
challenges with specific mathematical and physical concepts. In this paper, we
motivate the need for this framework and demonstrate its utility for both
researchers and course instructors by applying it to frame results from
interview data on students' use of Taylor approximations.Comment: 10 pages, 1 figures, 2 tables, accepted to the 2012 PERC Proceeding
Possible evidence of a spontaneous spin-polarization in mesoscopic 2D electron systems
We have experimentally studied the non-equilibrium transport in low-density
clean 2D electron systems at mesoscopic length scales. At zero magnetic field
(B), a double-peak structure in the non-linear conductance was observed close
to the Fermi energy in the localized regime. From the behavior of these peaks
at non-zero B, we could associate them to the opposite spin states of the
system, indicating a spontaneous spin polarization at B = 0. Detailed
temperature and disorder dependence of the structure shows that such a
splitting is a ground state property of the low-density 2D systems.Comment: 7 pages, 5 figure
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