Poetry, Ceremony and Celebration in The Consolatoria To The Countess Of Castro By Gómez Manrique

La «Consolatoria a la Condesa de Castro» de Gómez Manrique viene siendo interpretada como una aplicación del contemptu mundi y de la doctrina senequista para consolar a la hermana del poeta, la familia de cuyo marido había perdido sus bienes en el transcurso de las guerras civiles. El análisis de algunos aspectos de su contenido y del momento de su composición sugieren muy al contrario que el autor, bajo esta apariencia, estaba en realidad celebrando o estimulando la próxima restitución de dichos bienes, aplicando aquellos principios morales al servicio de los intereses políticos y personales de su familia.The «Consolatoria a la Condesa de Castro « by Gómez Manrique has been interpreted as the use of the contemptu mundi and of the Senequist doctrine to console the poet’s sister, whose husband’s family had lost their property during the civil wars. The analysis of some aspects of its content and moment of composition suggests quite the opposite: that the author, behind this appearance, was actually encouraging or celebrating the upcoming return of such property, applying the moral principles involved in the service of the political and personal interests of his family

What is the risk of progressive multifocal leukoencephalopathy in patients with ulcerative colitis or Crohn’s Disease treated with vedolizumab?

Background: Progressive multifocal leukoencephalopathy is a serious condition linked to certain diseases and immunosuppressant therapies, including the α4 integrin antagonist natalizumab. No cases have been reported to date with vedolizumab, a selective antagonist of the α4β7 integrin expressed on gut-homing lymphocytes. This analysis aimed to describe the current and future expected occurrence of progressive multifocal leukoencephalopathy with vedolizumab use, were the risk the same as in other populations in which this disease has been studied. Methods: The expected number of vedolizumab-associated progressive multifocal leukoencephalopathy cases was estimated up to May 19, 2016 and modelled up to 2034. These estimates were based on the cumulative exposure to the drug, assuming an equivalent risk to that of patients treated with natalizumab or those from other reference populations where progressive multifocal leukoencephalopathy has been examined. Future cases were modelled based on similar risks and projected sales. Results: The cumulative vedolizumab exposure was estimated at 54,619 patient-years, with a 95% confidence interval of 0.0–6.75 cases per 100,000 patient-years. An estimated 30.2 (95% confidence interval 19.4–40.9) cases of progressive multifocal leukoencephalopathy would have occurred if vedolizumab had the same risk as that of natalizumab. There would be a 50% chance of the first case occurring by 2018, assuming an equivalent risk to the general population. Conclusions: These analyses indicate the risk of progressive multifocal leukoencephalopathy with vedolizumab is small, and unlikely to be above 6.75 cases per 100,000 patient-years

Conflictos políticos y creación literaria entre Santillana y Gómez Manrique: la ‘Consolatoria a la condesa de Castro’

Edición y estudio de este poema de Gómez Manrique, de su gestación, de sus implicaciones culturales e ideológicas y de su intencionalidad políticaEditing and study of this poem by Gómez Manrique, his gestation, his cultural and ideological implications and his political intention