Chemical Sensor for Haemodialysis Application

Abstract The water used to supply a haemodialysis center requires particular mode of treatment in order to achieve the best technical, economic and therapeutic distribution. Dialysis patients come in contact weekly with a large amount of water through the dialysis apparatus. It is therefore essential that this solution has a high quality and purity in terms of proper electrolyte composition, low concentration or absence of organic and inorganic chemical pollutants, low concentration or absence of bacteria, yeasts, fungi and endotoxins. The chemical and microbiological quality of water intended for medical and biomedical treatments, such as haemodialysis, is generally defined on the basis of a plurality of international reference standards (ASTM International standards D1193 and D5196; International Pharmacopoeia and European Pharmacopoeia CAP / NCCLS 1988). In this work the authors have designed an electrochemical device used to characterize pure and ultrapure water for biomedical applications (Patent: TO2014A000765). The results obtained show a good ability of the device in the discrimination of different bacteria and of their concentration (CFU); Pseudomonas and E-coli have been here tested

Discrimination between oral corticosteroid-treated and oral corticosteroid-non-treated severe asthma patients by an electronic nose platform

Rationale: Some severe asthma patients require oral corticosteroids (OCS) likely due to greater disease severity. Exhaled molecular markers can provide phenotypic information in asthma. Objectives: Determine whether patients on OCS (OCS+) have a different breathprint compared with those who were not on OCS (OCS-); determine the classification accuracy of eNose as compared to FEV1 % pred, % sputum eosinophils, and exhaled nitric oxide (FENO). Methods: This was a cross-sectional analysis of the U-BIOPRED cohort. Severe asthma was defined by IMI-criteria [Bel Thorax 2011]. OCS+ patients had daily OCS. OCS- patients had never had OCS and were on maintenance inhaled fluticasone equivalent >1000 μg/day. Exhaled volatile organic compounds trapped on adsorption tubes were analysed by centralized eNose platform (Owlstone Lonestar, Cyranose 320, Comon Invent, Tor Vergata TEN) including a total of 190 sensors. t test was used for comparing groups and support vector machine with leave-one-out cross-validation as a classifier. Results: 33 OCS+ (age 55±11yr, mean±SD, 52% female, 27% smokers, pre-bronchodilator FEV1 64.1±24% pred) and 40 OCS- severe asthma patients (age 54±15yr, mean±SD, 55% female, 35% smokers, pre-bronchodilator FEV1 61.8±24% pred) were studied. Sensor by sensor analysis showed that 56 sensors provided different mean values (change in sensor resistance or frequency) between groups (P<0.05). Accuracy of classification was as follows: eNose 71% (n=73), FENO 71% (n=70), FEV1 62% (n=73) and sputum eosinophils 59% (n=37). Conclusions: Preliminary results suggest OCS+ and OCS- severe asthma patients can be distinguished by an eNose platform

ANALYSIS OF LIFE INSURANCE INVESTMENT COMPOSITION

Economic recession and global mettle down have brought the question of insurance company investment to the forefront. Growing attention has shifted to the pattern of investments by the insurance and question of how to evaluate such investments. The aim of this research is to evaluate investment compositions which are made by life insurance companies in Indonesia, as well as to know the effects on the performance of Insurance companies

Environmental conditions influence the biochemical properties of the fruiting bodies of Tuber magnatum Pico

The influences of various factors, including the symbiosis established with the roots of specific tree species, on the production of volatiles in the fruiting bodies of Tuber magnatum have not been investigated yet. Volatiles in T. magnatum fruiting bodies were quantitatively and qualitatively determined by both PTR-MS and GC-MS in order to compare the accuracy of the two methods. An electronic nose was also used to characterize truffle samples. The influence of environmental changes on the antioxidant capabilities of fruiting bodies was also determined. Statistically significant differences were found between fruiting bodies with different origins. The relationship between the quality of white truffle fruiting bodies and their specific host plant is described along with an analysis of metabolites other than VOCs that have ecological roles. Our results indicate that the geographical origin (Italy and Istria) of the fruiting bodies is correlated with the quantity and quality of volatiles and various antioxidant metabolites. This is the first report characterizing antioxidant compounds other than VOCs in white truffles. The correlation between geographical origin and antioxidant contents suggests that these compounds may be useful for certifying the geographical origin of truffles

Biosensor -based multisensorial system; techonological design and clinical applications

Sensor performance are highly improved when single sensor array are organized in multidimensional systems or networks for particular application

Biosensor Based Multisensorial System: Technological Design and Clinical Applications

Background: Sensor performances are highly improved when single sensor arrays are organized in multidimensional systems or networks for particular applications. This is facilitated by the large improvements in the miniaturization process, power consumption reduction and data analysis techniques possible nowadays. Multidimensional sensor systems are conceived to mimic the mechanisms of human senses. Among them, the so-called electronic nose and tongue are becoming more and more popular. Methods: Anthocyanins are exploited here as chemical interactive materials for both quartz microbalance (QMB) transducers used as gas sensors and for electrodes used as liquid electrochemical sensors. The optical properties of anthocyanins are well established and widely used, but they have never been exploited as sensing materials for both gas and liquid sensors in non-optical applications. By using the same set of selected anthocyanins an integrated system has been realized, which includes a gas sensor array based on QMB and a sensor array for liquids made up of suitable Ion Sensitive Electrodes (ISEs). The arrays are also monitored from an optical point of view. Results: This embedded system, is intended to mimic the working principles of the nose, tongue and eyes, called BIONOTE (BIOsensorbased multisensorial system for mimicking NOse, Tongue and Eyes). Preliminary results are discussed. Conclusions: These results are relative to: (a) the characterization of the optical properties of the tested materials; (b) the performance of the whole system as gas sensor array with respect to ethanol, hexane and isopropyl alcohol detection (concentration range 0.1–7 ppm) and as a liquid sensor array (concentration range 73–98 μM)

A sensor which can be varied in humidity sensitivity: a first experience paving the way to new chemical sensors?

During last decades, a number of different sensors have been developing for different analytics to detect. A key aspect of those sensors is that each of them results with a fixed particular sensitivity. Consequently, at occurrence, it is necessary to use a plurality of sensors to arrange measures with different levels of sensitivity. This work intends to investigate the possibility to obtain different sensitivity, in particular with respect to humidity, from one sensor only. To this aim we investigated the resistive flex sensor, which has been already used for other applications but, as far as we know, never investigated for its potential properties as a chemical sensor. Results demonstrated how the resistive flex sensor behaves with different sensitivity values and different sensitivity curves for different bend conditions. Copyright © 2018 by SCITEPRESS – Science and Technology Publications, Lda. All rights reserved

Innovative IAQ organic sensor

An innovative organic sensor for the monitoring of indoor air quality is described. For office buildings and schools the main requirements are: temperature, RH %, O-2 and CO2 concentrations. Moreover low O2 and high CO2 concentrations can be hazardous. There are a lot of sensors based on different principal transducers that are able to detect very low concentrations of CO2, O-2, and RH%.The system is based on a resistive interdigital sensor based on an organic sensing material, anthocyanin. Anthocyanins are natural pigments widely distributed in nature: they are produced by plants as secondary metabolites responsible for the pigmentation of many flowers, fruits and vegetables. In this work authors show the possibility to use this innovative organic sensor to monitor indoor air quality by measuring O2 concentration shifts with respect to a standard of 20% (20.000 ppm) and the critical CO2 concentration value of about 5% (5000 ppm) which is comparable with OSHA (Occupational Safety &amp; Health Administration) standard in an eight-hour time-weighted average (TWA). (C) 2014 Published by Elsevier Ltd