Laser furnace and method for zone refining of semiconductor wafers

A method of zone refining a crystal wafer (116 FIG. 1) comprising the steps of focusing a laser beam to a small spot (120) of selectable size on the surface of the crystal wafer (116) to melt a spot on the crystal wafer, scanning the small laser beam spot back and forth across the surface of the crystal wafer (116) at a constant velocity, and moving the scanning laser beam across a predetermined zone of the surface of the crystal wafer (116) in a direction normal to the laser beam scanning direction and at a selectible velocity to melt and refine the entire crystal wafer (116)

Scent-marking displays provide honest signals of health and infection

Males of many species produce scent marks and other olfactory signals that function to intimidate rivals and attract females. It has been suggested that scent marks provide an honest, cheat-proof display of an individual's health and condition. Here we report several findings that address this hypothesis in wild-derived house mice (Mus musculus domesticus). (1) We exposed males to female odor, which induces an increase in testosterone, and found that sexual stimulation significantly increased the males' scent-marking and the attractiveness of their scent marks to females. (2) We challenged sexually stimulated males with a nonreplicating strain of bacteria (Salmonella enterica C5TS) to activate immunity and found that this significantly decreased the males' scent-marking and the attractiveness of their scent marks to females. (3) We collected scent marks from infected and sham-infected males when they were sexually stimulated or not, and we found that females could significantly discriminate the scent marks of infected versus control males, but only when the males were sexually stimulated. Taken together, our results indicate that male mice modulate their scent-marking display depending on their health and perceived mating opportunities. Increased scent marking enhances males' attractiveness to females, scent marks provide an honest indicator of bacterial infection (and perhaps immune activation), and females are able to assess the health of males more easily when males mark at a high rate. Copyright 2004.honest signaling theory; house mice; immunocompetence handicap hypothesis; Mus; parasite-mediated sexual selection; Salmonella; testosterone

Female scent accelerates growth of juvenile male mice

Abstract Exposing female house mice (Mus musculus) to male urinary scent accelerates their sexual development (Vandenbergh effect). Here, we tested whether exposing juvenile male mice to females’ urine similarly influences male growth and size of their sexual organs. We exposed three-week old male house mice to female urine or water (control) for ca. three months. We found that female-exposed males grew significantly faster and gained more body mass than controls, despite all males being reared on a controlled diet, but we detected no differences in males' muscle mass or sexual organs. In contrast, exposing juvenile males to male urine had no effect their growth. We tested whether the males' accelerated growth imposed functional trade-offs on males' immune resistance to an experimental infection. We challenged the same male subjects with an avirulent bacterial pathogen (Salmonella enterica), but found no evidence that faster growth impacted their bacterial clearance, body mass or survival during infection compared to controls. Our results provide the first evidence to our knowledge that juvenile male mice accelerate their growth when exposed to the urine of adult females, though we found no evidence that increased growth had negative trade-offs on immune resistance to infectious disease

Disinvesting in the City

Tax foreclosure offers an opportunity to investigate processes of disinvestment in the city. Prior research has not considered how tax foreclosure administration protects or further damages neighborhoods where foreclosure occurs. Detroit’s loss of households led to disinvestment in housing and demolition of structures. In addition, at each of the three stages of property foreclosure and disposition, implementers took actions that promised to encourage disinvestment in property by facilitating the spread of blight and encouraging negative externalities. This occurred because (1) foreclosures took many owner-occupied properties; (2) the sale of properties to government entities was small and did not promote reuse; and (3) the foreclosure auctions disadvantaged purchasers who would become owner-occupants, channeled properties in strong neighborhoods to investors at low prices, and sold properties disproportionately to destructive buyers

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

BackgroundLoss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol. It is not known whether such variants or therapeutic antagonism of ANGPTL3 are associated with a reduced risk of atherosclerotic cardiovascular disease.MethodsWe sequenced the exons of ANGPTL3 in 58,335 participants in the DiscovEHR human genetics study. We performed tests of association for loss-of-function variants in ANGPTL3 with lipid levels and with coronary artery disease in 13,102 case patients and 40,430 controls from the DiscovEHR study, with follow-up studies involving 23,317 case patients and 107,166 controls from four population studies. We also tested the effects of a human monoclonal antibody, evinacumab, against Angptl3 in dyslipidemic mice and against ANGPTL3 in healthy human volunteers with elevated levels of triglycerides or LDL cholesterol.ResultsIn the DiscovEHR study, participants with heterozygous loss-of-function variants in ANGPTL3 had significantly lower serum levels of triglycerides, HDL cholesterol, and LDL cholesterol than participants without these variants. Loss-of-function variants were found in 0.33% of case patients with coronary artery disease and in 0.45% of controls (adjusted odds ratio, 0.59; 95% confidence interval, 0.41 to 0.85; P=0.004). These results were confirmed in the follow-up studies. In dyslipidemic mice, inhibition of Angptl3 with evinacumab resulted in a greater decrease in atherosclerotic lesion area and necrotic content than a control antibody. In humans, evinacumab caused a dose-dependent placebo-adjusted reduction in fasting triglyceride levels of up to 76% and LDL cholesterol levels of up to 23%.ConclusionsGenetic and therapeutic antagonism of ANGPTL3 in humans and of Angptl3 in mice was associated with decreased levels of all three major lipid fractions and decreased odds of atherosclerotic cardiovascular disease. (Funded by Regeneron Pharmaceuticals and others; ClinicalTrials.gov number, NCT01749878 .)