A Study of the Effect of the Position of an Edge Filter Within a Ratiometric Wavelength Measurement System

The effect of the position of an edge filter within a ratiometric wavelength measurement system was investigated based on three cases: (1) the reflected fibre Bragg grating (FBG) signal passes through both the reference arm and the edge filter arm, (2) the reflected FBG signal is connected directly to the edge filter arm and does not pass through the reference arm, (3) the edge filter sits in line with the FBG and thus the source power is filtered prior to reaching the FBG. Both numerical simulations and experimental results show that cases 1 and 2 have similar system performance whilst case 3 is the best arrangement which offers the highest wavelength resolution

A bioinformatics approach to the identification of hub genes of Huo Xin Pill (HXP) for the treatment of acute myocardial infarction

Purpose: To apply bioinformatics for the identification of potential genes associated with Huo Xin Pill (HXP), a traditional Chinese medicine (TCM) used for the treatment of acute myocardial infarction AMI).Methods: Mouse AMI expression profile dataset GSE153485 and HXP-treated mouse AMI expression profile dataset GSE147365 were downloaded from GEO database. Then, R software was used to screen differentially-expressed genes in AMI and differentially-expressed genes in HXP-treated AMI. Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, Venn diagrams, and protein-protein interaction (PPI) analysis were carried out on the hub genes linked to the effect of HXP on AMI.Results: Six hub genes were identified. Based on the differential analysis of the sham and AMI groups, GSE153485 and GSE147365 had 840 and 2116 differentially-expressed genes, respectively (p < 0.05). The GO and KEGG analyses revealed enrichments in actin filament organization, membrane repolarization, and regulation of the actin cytoskeleton. Differential analysis of the use of HXP on AMI showed that GSE147365 had 380 differentially-expressed genes, comprising 96 up-regulated genes and 284 down-regulated genes (p < 0.05). Thirteen potential acting target genes were obtained using a enn diagram, while 6 key acting genes were obtained via final screening.Conclusion: Six (6) hub genes linked to HXP and AMI have been identified using bioinformatics: Egr2, Tubb2a, Col4a2, Cnn2, Lmna, and Col4a1. This study provides a partial experimental basis for the use of HXP in the treatment of AMI. In addition, it provides new potential targets for the treatment of AMI

Use of a Bent Single SMS Fiber Structure for Simultaneous Measurement of Displacement and Temperature Sensing

We have proposed the use of a single bent single-multiple-single mode (SMS) fiber structure to measure both displacement and temperature simultaneously and independently. Our experimental results show that this sensor has a sensitivity of 5.89 pm/μm for displacement and 11.6 pm/ºC for temperature

Numerical Study of an Ion-Exchanged Glass Waveguide Using Both Two-Dimensional and Three-Dimensional Models

A numerical study is carried out to compare the two-dimensional (2-D) case and three-dimensional (3-D) case for the modelling of an ion-exchanged glass waveguide. It is shown that different waveguide widths on the photomask correspond to different ion concentration distributions after an annealing process. A numerical example is presented of two waveguide sections with different widths indicates that due to the abrupt change of the waveguide width, a 3-D theoretical model is required for an accurate prediction of the parameters of ion-exchanged glass waveguides. The good agreement between the modelled and measured results proves that the developed 3-D numerical model can be beneficially utilized in the generalized design of optical devices based on ion-exchange waveguides

Investigation of Macrobending Losses of Standard Single Mode Fiber with Small Bend Radii

An investigation of macrobending loss characteristics of a standard singlemode fiber (SMF28) for small bend radii is presented theoretically and experimentally, which includes the bend loss of the SMF28 with coating layers and the bare SMF28 after stripping the coating layers and chemical etching of partial cladding. The significant influence of reflection occurring at the interface between the cladding and coating layer or the cladding layer and air on the bend loss is investigated theoretically and experimentally

Light Coupling Between a Singlemode-Multimode-Singlemode (SMS) Fiber Structure and a Long Period Fiber Gating

We propose a novel optical coupling technique based on evanescent field coupling between a singlemode-multimode-singlemode (SMS) fiber structure and a long period fiber grating (LPFG). By parallel placement of the two fiber sections in close proximity to each other, the excited multi-cladding modes from the SMS fiber section can be selectively coupled to the guided mode in the LPFG, and vice versa. A theoretical analysis based for such a structure is undertaken and the simulated results are verified by experiments demonstrating a maximum coupling efficiency of up to 1.66% (which could be improved to 27.5% in theory) over a broadband resonance (42 nm with a 3 dB bandwidth)

Highly asymmetric rice genomes

<p>Abstract</p> <p>Background</p> <p>Individuals in the same species are assumed to share the same genomic set. However, it is not unusual to find an orthologous gene only in small subset of the species, and recent genomic studies suggest that structural rearrangements are very frequent between genomes in the same species. Two recently sequenced rice genomes <it>Oryza sativa </it>L. var. Nipponbare and <it>O. sativa </it>L. var. 93-11 provide an opportunity to systematically investigate the extent of the gene repertoire polymorphism, even though the genomic data of 93-11 derived from whole-short-gun sequencing is not yet as complete as that of Nipponbare.</p> <p>Results</p> <p>We compared gene contents and the genomic locations between two rice genomes. Our conservative estimates suggest that at least 10% of the genes in the genomes were either under presence/absence polymorphism (5.2%) or asymmetrically located between genomes (4.7%). The proportion of these "asymmetric genes" varied largely among gene groups, in which disease resistance (<it>R</it>) genes and the <it>RLK </it>kinase gene group had 11.6 and 7.8 times higher proportion of asymmetric genes than housekeeping genes (<it>Myb </it>and <it>MADS</it>). The significant difference in the proportion of asymmetric genes among gene groups suggests that natural selection is responsible for maintaining genomic asymmetry. On the other hand, the nucleotide diversity in 17 <it>R </it>genes under presence/absence polymorphism was generally low (average nucleotide diversity = 0.0051).</p> <p>Conclusion</p> <p>The genomic symmetry was disrupted by 10% of asymmetric genes, which could cause genetic variation through more unequal crossing over, because these genes had no allelic counterparts to pair and then they were free to pair with homologues at non-allelic loci, during meiosis in heterozygotes. It might be a consequence of diversifying selection that increased the structural divergence among genomes, and of purifying selection that decreased nucleotide divergence in each <it>R </it>gene locus.</p

Evoke: Evoking Critical Thinking Abilities in LLMs via Reviewer-Author Prompt Editing

Large language models (LLMs) have made impressive progress in natural language processing. These models rely on proper human instructions (or prompts) to generate suitable responses. However, the potential of LLMs are not fully harnessed by commonly-used prompting methods: many human-in-the-loop algorithms employ ad-hoc procedures for prompt selection; while auto prompt generation approaches are essentially searching all possible prompts randomly and inefficiently. We propose Evoke, an automatic prompt refinement framework. In Evoke, there are two instances of a same LLM: one as a reviewer (LLM-Reviewer), it scores the current prompt; the other as an author (LLM-Author), it edits the prompt by considering the edit history and the reviewer's feedback. Such an author-reviewer feedback loop ensures that the prompt is refined in each iteration. We further aggregate a data selection approach to Evoke, where only the hard samples are exposed to the LLM. The hard samples are more important because the LLM can develop deeper understanding of the tasks out of them, while the model may already know how to solve the easier cases. Experimental results show that Evoke significantly outperforms existing methods. For instance, in the challenging task of logical fallacy detection, Evoke scores above 80, while all other baseline methods struggle to reach 20