First-principles study of high conductance DNA sequencing with carbon nanotube electrodes

Rapid and cost-effective DNA sequencing at the single nucleotide level might be achieved by measuring a transverse electronic current as single-stranded DNA is pulled through a nano-sized pore. In order to enhance the electronic coupling between the nucleotides and the electrodes and hence the current signals, we employ a pair of single-walled close-ended (6,6) carbon nanotubes (CNTs) as electrodes. We then investigate the electron transport properties of nucleotides sandwiched between such electrodes by using first-principles quantum transport theory. In particular we consider the extreme case where the separation between the electrodes is the smallest possible that still allows the DNA translocation. The benzene-like ring at the end cap of the CNT can strongly couple with the nucleobases and therefore both reduce conformational fluctuations and significantly improve the conductance. The optimal molecular configurations, at which the nucleotides strongly couple to the CNTs, and which yield the largest transmission, are first identified. Then the electronic structures and the electron transport of these optimal configurations are analyzed. The typical tunneling currents are of the order of 50 nA for voltages up to 1 V. At higher bias, where resonant transport through the molecular states is possible, the current is of the order of several $\mu$A. Below 1 V the currents associated to the different nucleotides are consistently distinguishable, with adenine having the largest current, guanine the second-largest, cytosine the third and finally thymine the smallest. We further calculate the transmission coefficient profiles as the nucleotides are dragged along the DNA translocation path and investigate the effects of configurational variations. Based on these results we propose a DNA sequencing protocol combining three possible data analysis strategies.Comment: 12 pages, 17 figures, 3 table

Monte Carlo simulations of random copolymers at a selective interface

We investigate numerically using the bond--fluctuation model the adsorption of a random AB--copolymer at the interface between two solvents. From our results we infer several scaling relations: the radius of gyration of the copolymer in the direction perpendicular to the interface ($R_{gz}$) scales with $\chi$, the interfacial selectivity strength, as $R_{gz}=N^{\nu}f(\sqrt{N}\chi)$ where $\nu$ is the usual Flory exponent and $N$ is the copolymer's length; furthermore the monomer density at the interface scales as $\chi^{2\nu}$ for small $\chi$. We also determine numerically the monomer densities in the two solvents and discuss their dependence on the distance from the interface.Comment: Latex text file appended with figures.tar.g

3D characterization of CdSe nanoparticles attached to carbon nanotubes

The crystallographic structure of CdSe nanoparticles attached to carbon nanotubes has been elucidated by means of high resolution transmission electron microscopy and high angle annular dark field scanning transmission electron microscopy tomography. CdSe rod-like nanoparticles, grown in solution together with carbon nanotubes, undergo a morphological transformation and become attached to the carbon surface. Electron tomography reveals that the nanoparticles are hexagonal-based with the (001) planes epitaxially matched to the outer graphene layer.Comment: 7 pages, 8 figure

Multiple agency perspective, family control, and private information abuse in an emerging economy

Using a comprehensive sample of listed companies in Hong Kong this paper investigates how family control affects private information abuses and firm performance in emerging economies. We combine research on stock market microstructure with more recent studies of multiple agency perspectives and argue that family ownership and control over the board increases the risk of private information abuse. This, in turn, has a negative impact on stock market performance. Family control is associated with an incentive to distort information disclosure to minority shareholders and obtain private benefits of control. However, the multiple agency roles of controlling families may have different governance properties in terms of investors’ perceptions of private information abuse. These findings contribute to our understanding of the conflicting evidence on the governance role of family control within a multiple agency perspectiv

Density waves and 1/f1/f density fluctuations in granular flow

We simulate the granular flow in a narrow pipe with a lattice-gas automaton model. We find that the density in the system is characterized by two features. One is that spontaneous density waves propagate through the system with well-defined shapes and velocities. The other is that density waves are so distributed to make the power spectra of density fluctuations as $1/f^{\alpha}$ noise. Three important parameters make these features observable and they are energy dissipation, average density and the rougness of the pipe walls.Comment: Latex (with ps files appended

Steady state properties of a driven granular medium

We study a two-dimensional granular system where external driving force is applied to each particle in the system in such a way that the system is driven into a steady state by balancing the energy input and the dissipation due to inelastic collision between particles. The velocities of the particles in the steady state satisfy the Maxwellian distribution. We measure the density-density correlation and the velocity-velocity correlation functions in the steady state and find that they are of power-law scaling forms. The locations of collision events are observed to be time-correlated and such a correlation is described by another power-law form. We also find that the dissipated energy obeys a power-law distribution. These results indicate that the system evolves into a critical state where there are neither characteristic spatial nor temporal scales in the correlation functions. A test particle exhibits an anomalous diffusion which is apparently similar to the Richardson law in a three-dimensional turbulent flow.Comment: REVTEX, submitted to Phys. Rev.

Phase-sensitive Evidence for d-wave Pairing Symmetry in Electron-doped Cuprate Superconductors

We present phase-sensitive evidence that the electron-doped cuprates Nd1.85Ce0.15CuO4-y (NCCO) and Pr1.85Ce0.15CuO4-y (PCCO) have d-wave pairing symmetry. This evidence was obtained by observing the half-flux quantum effect, using a scanning SQUID microscope, in c-axis oriented films of NCCO or PCCO epitaxially grown on tricrystal [100] SrTiO3 substrates designed to be frustrated for a d(x2-y2) order parameter. Samples with two other configurations, designed to b unfrustrated for a d-wave superconductor, do not show the half-flux quantum effect.Comment: 4 pages, Latex, 4 figure

On Holographic description of the Kerr-Newman-AdS-dS black holes

In this paper, we study the holographic description of the generic four-dimensional non-extremal Kerr-Newman-AdS-dS black holes. We find that if focusing on the near-horizon region, for the massless scalar scattering in the low-frequency limit, there exists hidden conformal symmetry on the solution space. Similar to the Kerr case, this suggests that the Kerr-Newman-AdS-dS black hole is dual to a two-dimensional CFT with central charges $c_L=c_R=\frac{6a(r_++r_\ast)}{k}$ and temperatures $T_L=\frac{k(r_+^2+r_\ast^2+2a^2)}{4\pi a\Xi(r_++r_\ast)}, T_R=\frac{k(r_+-r_\ast)}{4\pi a\Xi}$. The macroscopic Bekenstein-Hawking entropy could be recovered from the microscopic counting in dual CFT via the Cardy formula. Using the Minkowski prescription, we compute the real-time correlators of the scalar, photon and graviton in near horizon geometry of near extremal Kerr-AdS-dS black hole. In all these cases, the retarded Green's function and the corresponding absorption cross section are in perfect match with CFT prediction. We further discuss the low-frequency scattering of a charged scalar by a Kerr-Newman-AdS-dS black hole and find the dual CFT description.Comment: 22 pages; minor corrections, conlusion unchanged, references added;published versio

Multiwavelength Observations of the Gamma-Ray Blazar PKS 0528+134 in Quiescence

We present multiwavelength observations of the ultraluminous blazar-type radio loud quasar PKS 0528+134 in quiescence during the period July to December 2009. Significant flux variability on a time scale of several hours was found in the optical regime, accompanied by a weak trend of spectral softening with increasing flux. We suggest that this might be the signature of a contribution from the accretion disk at the blue end of the optical spectrum. The optical flux is weakly polarized with rapid variations of the degree and direction of polarization, while the polarization of the 43 GHz radio core remains steady. Optical spectropolarimetry suggests a trend of increasing degree of polarization with increasing wavelength, providing additional evidence for an accretion disc contribution towards the blue end of the optical spectrum. We constructed four SEDs indicating that even in the quiescent state, the bolometric luminosity of PKS 0528+134 is dominated by its gamma-ray emission. A leptonic single-zone jet model produced acceptable fits to the SEDs with contributions to the high-energy emission from synchrotron self-Compton radiation and Comptonization of direct accretion disk emission. Fit parameters close to equipartition were obtained. The moderate variability on long time scales implies the existence of on-going particle acceleration, while the observed optical polarization variability seems to point towards a turbulent acceleration process. Turbulent particle acceleration at stationary features along the jet therefore appears to be a viable possibility for the quiescent state of PKS 0528+134.Comment: Accepted for Publication in The Astrophysical Journal. - Acknowledgement adde

Velocity and density profiles of granular flow in channels using lattice gas automaton

We have performed two-dimensional lattice-gas-automaton simulations of granular flow between two parallel planes. We find that the velocity profiles have non-parabolic distributions while simultaneously the density profiles are non-uniform. Under non-slip boundary conditions, deviation of velocity profiles from the parabolic form of newtonian fluids is found to be characterized solely by ratio of maximal velocity at the center to the average velocity, though the ratio depends on the model parameters in a complex manner. We also find that the maximal velocity ($u_{max}$) at the center is a linear function of the driving force (g) as $u_{max} = \alpha g - \delta$ with non-zero $\delta$ in contrast with newtonian fluids. Regarding density profiles, we observe that densities near the boundaries are higher than those in the center. The width of higher densities (above the average density) relative to the channel width is a decreasing function of a variable which scales with the driving force (g), energy dissipation parameter ($\epsilon$) and the width of the system (L) as $g^{\mu} L^{\nu}/\epsilon$ with exponents $\mu = 1.4 \pm 0.1$ and $\nu = 0.5 \pm 0.1$. A phenomenological theory based on a scaling argument is presented to interpret these findings.Comment: Latex, 15 figures, to appear in PR