256 research outputs found
Undergraduate Research: A Bridge to Graduate Education in Agricultural Biotechnology for Hispanics
Hispanics lag behind all other U.S. ethnic groups in education, and are especially poorly represented in science careers. Undergraduate research is an efficient method to attract undergraduate students to science, and many universities are taking advantage of this; however, much still needs to be done to fully explore its potential. In 2000, Texas A&M University-Kingsville, in collaboration with the University of Texas at Brownsville and the University of Texas Pan-American, initiated a undergraduate research internship program in citrus biotechnology to channel Hispanic undergraduate students into graduate education. To date, 51 internships have been provided, and 20 students have been channeled into graduate school, including four at the doctoral level. Most were first-generation college students
Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.
Evolution of dopant-induced helium nanoplasmas
Two-component nanoplasmas generated by strong-field ionization of doped
helium nanodroplets are studied in a pump-probe experiment using few-cycle
laser pulses in combination with molecular dynamics simulations. High yields of
helium ions and a pronounced, droplet size-dependent resonance structure in the
pump-probe transients reveal the evolution of the dopant-induced helium
nanoplasma. The pump-probe dynamics is interpreted in terms of strong inner
ionization by the pump pulse and resonant heating by the probe pulse which
controls the final charge states detected via the frustration of electron-ion
recombination
Glucocorticoid receptor activation stimulates the Na-Cl co-transporter and influences the diurnal rhythm of its phosphorylation
The sodium-chloride cotransporter (NCC) in the distal convoluted tubule contributes importantly to sodium balance and blood pressure (BP) regulation. NCC phosphorylation determines transport activity and has a diurnal rhythm influenced by glucocorticoids. Disturbing this rhythm induces “nondipping” BP, an abnormality that increases cardiovascular risk. The receptor through which glucocorticoids regulate NCC is not known. In this study, we found that acute administration of corticosterone to male C57BL6 mice doubled NCC phosphorylation without affecting total NCC abundance in both adrenalectomized and adrenal-intact mice. Corticosterone also increased the whole kidney expression of canonical clock genes: period circadian protein homolog 1 (Per1), Per2, cryptochrome 1, and aryl hydrocarbon receptor nuclear translocator-like protein 1. In adrenal-intact mice, chronic blockade of glucocorticoid receptor (GR) with RU486 did not change total NCC but prevented corticosterone-induced NCC phosphorylation and activation of clock genes. Blockade of mineralocorticoid receptor (MR) with spironolactone reduced the total pool of NCC but did not affect stimulation by corticosterone. The diurnal rhythm of NCC phosphorylation, measured at 6-h intervals, was blunted by chronic GR blockade, and a similar dampening of diurnal variation was seen in GR heterozygous null mice. These effects on NCC phosphorylation did not reflect altered rhythmicity of plasma corticosterone or serum and glucocorticoid-induced kinase 1 activity. Both mineralocorticoids and glucocorticoids emerge as regulators of NCC, acting via distinct receptor pathways. MR activation provides maintenance of the NCC protein pool; GR activation dynamically regulates NCC phosphorylation and establishes the diurnal rhythm of NCC activity. This study has implications for circadian BP homeostasis, particularly in individuals with abnormal glucocorticoid signaling as is found in chronic stress and corticosteroid therapy.</p
An all-solid-state laser source at 671 nm for cold atom experiments with lithium
We present an all solid-state narrow line-width laser source emitting
output power at delivered in a
diffraction-limited beam. The \linebreak source is based on a
fre-quency-doubled diode-end-linebreak pumped ring laser operating on the
transition in Nd:YVO. By using
periodically-poled po-tassium titanyl phosphate (ppKTP) in an external build-up
cavity, doubling efficiencies of up to 86% are obtained. Tunability of the
source over is accomplished. We demonstrate the suitability of
this robust frequency-stabilized light source for laser cooling of lithium
atoms. Finally a simplified design based on intra-cavity doubling is described
and first results are presented
Gustatory Imagery Reveals Functional Connectivity from the Prefrontal to Insular Cortices Traced with Magnetoencephalography
Our experience and prejudice concerning food play an important role in modulating gustatory information processing; gustatory memory stored in the central nervous system influences gustatory information arising from the peripheral nervous system. We have elucidated the mechanism of the 'top-down" modulation of taste perception in humans using functional magnetic resonance imaging (fMRI) and demonstrated that gustatory imagery is mediated by the prefrontal (PFC) and insular cortices (IC). However, the temporal order of activation of these brain regions during gustatory imagery is still an open issue. To explore the source of "top-down" signals during gustatory imagery tasks, we analyzed the temporal activation patterns of activated regions in the cerebral cortex using another non-invasive brain imaging technique, magnetoencephalography (MEG). Gustatory imagery tasks were presented by words (Letter G-V) or pictures (Picture G-V) of foods/beverages, and participants were requested to recall their taste. In the Letter G-V session, 7/9 (77.8%) participants showed activation in the IC with a latency of 401.7 +/- 34.7 ms (n = 7) from the onset of word exhibition. In 5/7 (71.4%) participants who exhibited IC activation, the PFC was activated prior to the IC at a latency of 315.2 +/- 56.5 ms (n = 5), which was significantly shorter than the latency to the IC activation. In the Picture G-V session, the IC was activated in 6/9 (66.7%) participants, and only 1/9 (11.1%) participants showed activation in the PFC. There was no significant dominance between the right and left IC or PFC during gustatory imagery. These results support those from our previous fMRI study in that the Letter G-V session rather than the Picture G-V session effectively activates the PFC and IC and strengthen the hypothesis that the PFC mediates "top-down" control of retrieving gustatory information from the storage of long-term memories and in turn activates the IC
An integrated online radioassay data storage and analytics tool for nEXO
Large-scale low-background detectors are increasingly used in rare-event
searches as experimental collaborations push for enhanced sensitivity. However,
building such detectors, in practice, creates an abundance of radioassay data
especially during the conceptual phase of an experiment when hundreds of
materials are screened for radiopurity. A tool is needed to manage and make use
of the radioassay screening data to quantitatively assess detector design
options. We have developed a Materials Database Application for the nEXO
experiment to serve this purpose. This paper describes this database, explains
how it functions, and discusses how it streamlines the design of the
experiment
Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis
Invasive aspergillosis (IA) is a common and life-threatening infection in immunocompromised individuals. A number of environmental and epidemiologic risk factors for developing IA have been identified. However, genetic factors that affect risk for developing IA have not been clearly identified. We report that host genetic differences influence outcome following establishment of pulmonary aspergillosis in an exogenously immune suppressed mouse model. Computational haplotype-based genetic analysis indicated that genetic variation within the biologically plausible positional candidate gene plasminogen (Plg; Gene ID 18855) correlated with murine outcome. There was a single nonsynonymous coding change (Gly110Ser) where the minor allele was found in all of the susceptible strains, but not in the resistant strains. A nonsynonymous single nucleotide polymorphism (Asp472Asn) was also identified in the human homolog (PLG; Gene ID 5340). An association study within a cohort of 236 allogeneic hematopoietic stem cell transplant (HSCT) recipients revealed that alleles at this SNP significantly affected the risk of developing IA after HSCT. Furthermore, we demonstrated that plasminogen directly binds to Aspergillus fumigatus. We propose that genetic variation within the plasminogen pathway influences the pathogenesis of this invasive fungal infection
Partially distributed coordination with Reo and constraint automata
Algorithms and the Foundations of Software technolog
Performance of novel VUV-sensitive Silicon Photo-Multipliers for nEXO
Liquid xenon time projection chambers are promising detectors to search for
neutrinoless double beta decay (0), due to their response
uniformity, monolithic sensitive volume, scalability to large target masses,
and suitability for extremely low background operations. The nEXO collaboration
has designed a tonne-scale time projection chamber that aims to search for
0 of \ce{^{136}Xe} with projected half-life sensitivity of
~yr. To reach this sensitivity, the design goal for nEXO is
1\% energy resolution at the decay -value (~keV).
Reaching this resolution requires the efficient collection of both the
ionization and scintillation produced in the detector. The nEXO design employs
Silicon Photo-Multipliers (SiPMs) to detect the vacuum ultra-violet, 175 nm
scintillation light of liquid xenon. This paper reports on the characterization
of the newest vacuum ultra-violet sensitive Fondazione Bruno Kessler VUVHD3
SiPMs specifically designed for nEXO, as well as new measurements on new test
samples of previously characterised Hamamatsu VUV4 Multi Pixel Photon Counters
(MPPCs). Various SiPM and MPPC parameters, such as dark noise, gain, direct
crosstalk, correlated avalanches and photon detection efficiency were measured
as a function of the applied over voltage and wavelength at liquid xenon
temperature (163~K). The results from this study are used to provide updated
estimates of the achievable energy resolution at the decay -value for the
nEXO design
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