Motoric training alters speech sound perception and production – active listening does not lead into learning outcomes

Accurate speech-sound perception and production are prerequisites for communication in a non-native language. Earlier research has shown that new categorization and pronunciation patterns evolve in different learning settings and that these skills can be trained with various methods. We tested the effects of two types of training protocols on the production and identification of L2 vowels embedded in a pseudo-word context. Group 1 (Producers) participated in a listen and repeat training, where they produced the target stimulus /tᵾ:ti/ and the non-target stimulus /ty:ti/ after the example in a pseudo-randomized order; Group 2 (Listeners) was instructed to count the number of targets /tᵾ:ti/ in the same stimulus train without any motoric production movements. The results showed clearly that listen and repeat training led to plastic changes both in production and in identification, while no learning effects were obtained with the listening paradigm. This suggests a significant role of motoric experience in the acquisition of speech.Peer reviewe

NON-NATIVE SPEECH SOUND PRODUCTION CHANGES EVEN WITH PASSIVE LISTENING TRAINING

The difficulty of non-native speech sound acquisition depends on several factors in addition to the central role of the mother tongue sound system. Age of exposure, amount of exposure as well as the type of training provided have been shown to have an effect on learning outcomes. In addition, theories of speech perception suggest that perception and production may either be strongly dependent upon each other as to the degree that perception triggers motoric patterns as well, or that activation of the auditory system is enough for perception so that the production system remains inactivated. In order to study whether mere exposure to auditory stimulation would result in production changes, we selected two groups of Finnish learners in a two-day listen-and-repeat training protocol. Both groups were auditively exposed to a non-native speech sound contrast embedded in a semi-synthetically produced pseudo-word context /ty:ti/ - /tʉ:ti/.  While the passive listening group merely listened to the stimulus pairs without any motoric actions, the production group actively produced the stimulus words according to the provided model. We performed acoustic analyses and extracted the values of the two lowest resonance frequencies, formant 1 (F1) and formant 2 (F2) from the productions. The results indicated no statistically significant differences between the groups, neither in the formant values nor in their standard deviations. However, as a function of training, both groups showed clear changes in the standard deviation values thus indicating changes in production performances. This suggests that both training protocols have an effect on production learning, and more importantly, that the motoric commands seem to alter on the basis of mere auditory stimulation. This further suggests that the motoric system is activated even in perceptual tasks.</p

Motoric Training Alters Speech Sound Perception and Production — Active Listening Training Does Not Lead into Learning Outcomes

Abstract—Accurate speech-sound perception and production are prerequisites for communication in a nonnative language. Earlier research has shown that new categorization and pronunciation patterns evolve in different learning settings and that these skills can be trained with various methods. We tested the effects of two types of training protocols on the production and identification of L2 vowels embedded in a pseudo-word context. Group 1 (Producers) participated in a listen and repeat training, where they produced the target stimulus /tᵾ:ti/ and the non-target stimulus /ty:ti/ after the example in a pseudo-randomized order; Group 2 (Listeners) was instructed to count the number of targets /tᵾ:ti/ in the same stimulus train without any motoric production movements. The results showed clearly that listen and repeat training led to plastic changes both in production and in identification, while no learning effects were obtained with the listening paradigm. This suggests a significant role of motoric experience in the acquisition of speech. Index Terms—non-native vowel production, vowel identification, active auditory and motoric training</p

Adult learners and a one-day production training – Small changes but the native language sound system prevails

Peer reviewe

18th International Congress of Phonetic Sciences

The perception and production of non-native speech sounds is the key to learning a new language. The differences between the native and the target language sound systems cause learning problems, but orthographic conventions may also affect the learning process. We tested whether a misleading orthography in contrast to phonemic transcription affects the manner in which native Finns learn to produce a non-native speech sound embedded in a pseudo word context. After the two day training protocol, the subjects who, in addition to the acoustic stimulation, were exposed to transcription cues, significantly changed their non-native productions according to the target. In contrast, the subjects who trained with the orthographic stimuli, changed their productions away from the acoustic target and towards the visual one. This result suggests that visual information is of crucial importance in learning to modulate articulation according to the target language model.</p

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Abstract Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P &lt;5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate&lt;0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Abstract Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10−72), with similar effects for males and females. Chromosome Xq23 lipid-lowering alleles are associated with reduced odds for CHD among 42,545 cases and 591,247 controls (P = 1.7 × 10−4), and reduced odds for diabetes mellitus type 2 among 54,095 cases and 573,885 controls (P = 1.4 × 10−5). Although we observe an association with increased BMI, waist-to-hip ratio adjusted for BMI is reduced, bioimpedance analyses indicate increased gluteofemoral fat, and abdominal MRI analyses indicate reduced visceral adiposity. Co-localization analyses strongly correlate increased CHRDL1 gene expression, particularly in adipose tissue, with reduced concentrations of blood lipids

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele